Conserved Protein Domain Family
CENP-L
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pfam13092: CENP-L 
Kinetochore complex Sim4 subunit Fta1
CENP-L is one of the components that assembles onto the CENP-A-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. Fta1 is the equivalent component of the fission yeast Sim4 complex. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals.
Links
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Statistics
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PSSM-Id: 432969
Aligned: 74 rows
Threshold Bit Score: 91.497
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003347922 302 HFVHLPLLLLRMPAPLKSVITDFLSTTFDCRVSSLRLGTRSLIQSWESWVQTAGipergpLAKDVVLNLGFYIPpaehng 381
XP_015211334 192 DFVCLPLFCASGAGSLTSLVKSWFETTFDCNFGQLRISPSNLHRLATMWTGCHPt----vNI--RYLKLSWTLP------ 259
XP_019207009 205 DFTCLPLFGSRGAENLTSLVKSWFQQTFDCCFGPLEINQTCLQWLAALWTNCHIe----sSI--QHLKMIWTLP------ 272
XP_023185752 187 DFTCLPLFCSKGAEDLSSLVKSWLQRTFDCCFGPLDINQTTLQWLAALWTNCHMe----tNI--QNLKMIWTLP------ 254
XP_004066642 188 DFTCLPLFGSRGPEYLSRVVKSWFQKTFDCCFGSLEINHTSLQWFAALWTDCHSq----sHI--QHLRMLWTIP------ 255
XP_003966497 204 DFTCLPLFCSSGPEAFTSVIKSWLQQNFDCCFGQLEISHTSLQWLMALWTNCHAe----sGI--QHLKMIWTLP------ 271
CAG06707     205 DFTCLPLFCSHGPEGLTSAIKSWFQRNFDCSFGPLELSHVSLQWLMALWTNCHAe----sGI--QHLKMIWSVP------ 272
XP_022533453 194 DFTSLPLFCSRGAESLSALVKSWFQRTFDCSFGALGLSSSTLHWLAALWTGCHP------AAGIRYLKLGWTMP------ 261
NP_001003878 181 DFVSLPLFCTSGPESLTNLVKSWFERAFDCNFGSLALNSSTLNWLAALWTGCHPa----cNI--RYLKLSWSLP------ 248
XP_003219906 186 DFTYLPLFFVYGAKGLSDLVETWLQQMFDCCCSPLQISPISLSWMAAMWSGCSMd----sRT--AETELTFSVP------ 253

XP_003347922 382 nalgvtggnggtgedkggdnegpvqpgQEPLGIkGIDVIIPAAELRGFVRAGKQivadrqgenekdnskekvnekptwea 461
XP_015211334 260 ---------------------------TCP-PL-DISYTVNPGDVSDLWSRICQg------------------------- 285
XP_019207009 273 ----------------------------VEPPL-QITYTVNSQDVWELWNSVRNpslesr-------------------- 303
XP_023185752 255 ----------------------------VLPPL-QVTYTVDSDDVLDLWRSTREssaeks-------------------- 285
XP_004066642 256 ----------------------------AAPPL-QITYTVDHQDAWDLWNSVRKgptaa--------------------- 285
XP_003966497 272 ----------------------------AEPPL-QVTYMVEPQDAWVLWNSLRNsqkhpen------------------- 303
CAG06707     273 ---------------------------VAP-PL-QVTYMVDPQDAWALWDSLRNsqrhskn------------------- 304
XP_022533453 262 ----------------------------TQPPL-DIEYSVDPQDAWELWNSVHKed------------------------ 288
NP_001003878 249 ---------------------------TEP-PL-DVLYTVNPQDAWELWNSIHPqe------------------------ 275
XP_003219906 254 ---------------------------YTAYPL-DISYSINPEDIKTLWDSIQRk------------------------- 280

XP_003347922 462 dlkkrrklagrlgeegwewrasvpgdndTDTDTQGQQSPFTEALGRYVDKHLGLNLFhpGVRVTKIACGGFVMSE-GRLK 540
XP_015211334 286 ----------------------------KDQVSSEVAKQFFQCLESHFFRHFRIHLS--AGELTKVSTALGSAYRdGKIQ 335
XP_019207009 304 -----------------------eeeeaARSIDIEEVTRFMQGLKSHFYRHFRLDLS--AGRLSQVSSALGSAKFsGRIK 358
XP_023185752 286 -----------------------reaedEVCIDFSEVTRFMQGLMSHFYRHFRVDLS--AGELNQVSSALGSAKVnGKIK 340
XP_004066642 286 ------------------------vaedAASIDLEEVTGFLQALKSHFYRHFRLDLS--AGTLQQVSTAVGSAKSsGRIK 339
XP_003966497 304 ----------------------tgddpeEDNIDIGEVKRFVQALKSHFYRHFRLDLS--AGRLSQVSTALGSAKCnGRIK 359
CAG06707     305 ----------------------algeleEDNIDLEEVMMFIQELKSHFYRHFRVDLS--AGSLNQVSTALGSAKCnGRIK 360
XP_022533453 289 --------------------------gaDERISVDEVQSFINGLETHFFRHFKIYLS--SGTLTKVSTALGSAHHhGKIK 340
NP_001003878 276 --------------------------ntDDRIDIKDVQAFMSGMETHFFRHFKIHLS--AGTLLKVSTALGSAHHdGKIK 327
XP_003219906 281 ----------------------------EREVCQEEVELFMECLYNHFHRHFKIYLS--ATRLVKVSTPVACAHStGKIK 330

XP_003347922 541 VFA 543
XP_015211334 336 FMN 338
XP_019207009 359 MSn 361
XP_023185752 341 ISS 343
XP_004066642 340 MSn 342
XP_003966497 360 MSn 362
CAG06707     361 ISn 363
XP_022533453 341 Mss 343
NP_001003878 328 Ign 330
XP_003219906 331 IFQ 333
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