3E0G,2Q7N


Conserved Protein Domain Family
LIFR_N
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pfam18207: LIFR_N 
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Leukemia inhibitory factor receptor N-terminal domain
This domain can be found in leukemia inhibitory factor receptor (LIFR). LIFR is a cell surface receptor that mediates the actions of LIF and other interleukin-6 type cytokines through the formation of signalling complexes with gp130. This is the N-terminal domain, referred to as domain 1, which contains conserved disulfide bonds between Cys-10 to Cys-20 and Cys-37 to Cys-45.
Links
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Statistics
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PSSM-Id: 436347
Aligned: 34 rows
Threshold Bit Score: 81.9854
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3E0G_A          1 DLKCVTNNLQVWQCSWKAPSGTGRGTDYEVCIEQRS----RSCYQLEKtSIKIP-ALSHGDYEITINSLHDFGSSTSK-- 73  
XP_005060551   35 NLKCVTHNLHKMLCTWDVSSRGRHGQT-DFCYTTNDlt-pQVCFKTKErRVEIP--IPESSITVTIKS-SGTASVTKE-- 107 
KGL84330       21 NLKCIMHNLHKMICTWDVSSKGRYGQT-DFCYATSDll-pPVCIKTREkRVEIPvSESSFTVIITTNSIYGAAFATKK-- 96  
KFP23045       21 NLKCVTHNLRKMICTWDVSSKARHGQT-DFCYTTNDlp-pPVCFKTKEkRVEILiPESSTTVTITTNSVSGTAFATKE-- 96  
OXB76736       57 NLKCVTHNLRKMVCTWEISSKRRHGQT-EFCYNADDlllsPVCFKTKEkRVEIPvPESFITMKITTYSISGIAFATRH-- 133 
KFP00600       20 NLRCVTHNLQKMICAWDVSFKGRHGQT-DFCYTTDDfp-lPVCFKTKEkRIEIAvPESSTTVTITTNSISGTTLATKG-- 95  
XP_006029000   35 TLRCITHDFNIMTCSWDAFSSTNLGQSYEFCYENSGl---LVCNKNKEkSADIP--IVHGSTTIKITTLNASGTPLATtt 109 
XP_006011971   34 KLQCITHDLKTVVCSWDADLDNSLGTAYEFCRLKLNk---DQCSEVGGnTSSTFdLVLFDIVTVNITAKNAHGSASKI-- 108 
XP_018121814   35 NLQCFTHNLETAVCSWVAPNTTKSDILYQICYSTSGs---SVCFSSNKsSLEVE-FETTAPLSISIKASNAQGSPEIR-- 108 
XP_028605365   36 NLTCITHDFKTVICTWTTASTASHGVEYSFCHSGRT-----SCLTTKEkTAQIDkLISFASNQIKISTMSQSGKVIAEnt 110 

3E0G_A         74 FTLNE 78  
XP_005060551  108 FVIHQ 112 
KGL84330       97 FVIHK 101 
KFP23045       97 FEIHK 101 
OXB76736      134 FEIRK 138 
KFP00600       96 FDIHK 100 
XP_006029000  110 FILPE 114 
XP_006011971  109 FSVKN 113 
XP_018121814  109 FQKTM 113 
XP_028605365  111 FELTD 115
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