3V69


Conserved Protein Domain Family
FILIA_N_like
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cd12795: FILIA_N_like 
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FILIA-N KH-like domain
This group contains the N-terminal atypical KH domain of FILIA and related domains. FILIA is expressed in oocytes and embryo, and contains an atypical KH domain at the N-terminus with an N-terminal extension that interacts with RNA. RNA-binding may mediate RNA transcript regulation in oogenesis and embryogenesis. FILIA-N differs from typical KH domains by forming a stable dimer in solution and crystal structure.
Links
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Statistics
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PSSM-Id: 240613
Aligned: 17 rows
Threshold Bit Score: 73.8922
Created: 1-Feb-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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dimer interface
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:3V69: Mus Musculus FILIA-N forms homodimers; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                 #       # ###      ###                 
3V69_A        28 PLDHKqgtLFEIIgepklPKWFHVECLEDPKRLYVEpRLLEIMFGKDGEHIPHLEs----MLHTLIHVNVW-GPERRAEI 102 house mouse
XP_003467075  17 SPKLKpwrSSAGLgeggrAWWTRPEHFRKPLVFYVDvEQEELVFGPRDAHGEGQLrrleeHSHTLIQLEAWaMPEGHTRV 96  domestic guinea...
NP_001238803  67 SKRSEqsmDMGTSalskkPWWTLPQNFHAPMVFHMEeDQEELIFGHGDTYLRCIEv----HSHTLIQLESWfTATGQTRV 142 human
NP_001041432  51 GSRSRgmsEMEMDaanknSWWMIPENFESPFMFFIDeDQEQHIFGHGDKYLRCIEe----HSSTFIQLEGWfTASGQTRV 126 Norway rat
XP_003404165  33 RQPGRaerARGEAaraekPWWTVPENFVAPLMFYMDeELEESVFGPRDADLHRIEe----HSGILIQLDKWfSASCQTRV 108 African savanna...
XP_003794349 261 SGLEGqkmEMLPKckdilPWLNVLEDLIDPKVLEVPpWLLEPMFGPDRSRISFFEk----VGKTMIELQTS-ESSAHTEI 335 small-eared galago
XP_001115338   4 CAQEVripHQDLKrrntlPWVKLPEDLKDPEVLLVQmRLLEAMFGPDGSQIPYIEq----VSKIMLMLKAL-ESLDLTEV 78  rhesus monkey
XP_867781     16 GASKKyshSKNWLlvhtqRYWCRFKHFLKPSVLHVDaRLLEKIFGPSRALVPGFEr----EFKVLLQMREP-NSEGKVEI 90  dog
XP_003404163  71 RSRREgfpLREGMpfvhlQHWCRFKHFMKPLVLHVEaCLLEKIFGPSRVLLPGFEr----EFKVVLQVGEP-DSDGMVEI 145 African savanna...
XP_003404160  55 NLPVFl--CPGRVdlrvlPNWFQKEHLENPAVCDVPaWQVEKIFGTEGKDIPGIEq----STETLLQVQIL-DPKGMARI 127 African savanna...

Feature 1              ##  #   #  ##  #                 
3V69_A       103 WIFGPPPFRRDVDRMLTDLAHYcRMKLMEI-EALEAGVE 140 house mouse
XP_003467075  97 SVVGPAGARRWLLELVRSLGSGePGARTRGlATLQLVRS 135 domestic guinea pig
NP_001238803 143 TVVGPHRARQWLLHMFCCVGSQdSYHHARGlEMLERVRS 181 human
NP_001041432 127 TVVGPFRAKHWLVDMIWNLCNQeAYHRARGqEMLDLVRK 165 Norway rat
XP_003404165 109 MIVGPIPARRWLLDMALNLGSSeFELQARGmIKLILCLV 147 African savanna elephant
XP_003794349 336 VVYGDLTYRARTTWMLQCLAERhRRQGQQEiVKLEEASS 374 small-eared galago
XP_001115338  79 VVYGFYLCKCRTKWMLQSMTEWhCQHQERGmLKLAESMT 117 rhesus monkey
XP_867781     91 LIMGRRRYRKRAKRLIRILAAKpRGKRYGG-TMMFSLET 128 dog
XP_003404163 146 LISGTHWYRKRAKRLIHILAARsRRKQSGG-TVMLGLES 183 African savanna elephant
XP_003404160 128 SIFGSQEKKELVEANIYCQRRWlHVVAEKE-KLVEALKI 165 African savanna elephant

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