3PQV


Conserved Protein Domain Family
18S_RNA_Rcl1p

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TIGR03400: 18S_RNA_Rcl1p 
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18S rRNA biogenesis protein RCL1
Members of this strictly eukaryotic protein family are not RNA 3'-phosphate cyclase (6.5.1.4), but rather a homolog with a distinct function, found in the nucleolus and required for ribosomal RNA processing. Homo sapiens has both a member of this RCL (RNA terminal phosphate cyclase like) family and EC 6.5.1.4, while Saccharomyces has a member of this family only.
Statistics
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PSSM-Id: 274564
Aligned: 23 rows
Threshold Bit Score: 403.527
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3PQV_A         9 VTFEGSRNFRLRVVMATLSGKAIKIEKIRSDDL-NPGLKDYEVSFLRLMEAVTNGSSIEISYTGTTVIFRPGIITG--GS 85  Kluyveromyces l...
P56175        11 LIYRGSNFLKQRLILACLSGKPVKISQIRSEDEtAPGLREYEISLIRLLDKITNGTKIELNPAGTSVMFSPGLLHG--GQ 88  fruit fly
XP_314471     11 LIYEGSNFLKQRLLLSTLSGKSIEVREIRPHHEtNPGLQEYETNLLQLLDKITNGTITRVDRDGCSFVYQPGLLYG--GV 88  Anopheles gambi...
Q23400         6 LEFSGCNFFRIRLAYSILSGRPIRIINIRKNDD-RPGIRDFESKLIGLLEKVTNGTKVEISRTGTQVIFRPGMITG--GV 82  Caenorhabditis ...
XP_843275      2 LHFEGSSLLRHHIVCSILSKRPVRITNIHDDED-PMGIQAHEANFLKFIDRVTSGSSLQCTDHNTTLQFTPGMILG--GS 78  Leishmania majo...
XP_813340      2 LEFEGSSLFRHHIVCSLLTNKPVRVSGIHDEDE-PQGIIATEANFLKFIDRVTGGSKFECTDNNTTLTFYPGMILG--GN 78  Trypanosoma cru...
XP_640201      2 LKFQGSTHFRQRIICSTLSGKAIRITNIRDEDE-KPGLRDYEASFLRLVDKITNGSKIEINSTGTQITYIPGIIIG--GK 78  Dictyostelium d...
Q9C578         5 KKMKGSQSFRQRLLLSTLSSTPISIDEIRADET-IPGLRPHEVNLLRLLEIVTDDAVVDINETGTRLKYKPGTIVG--GK 81  thale cress
NP_001051811   7 RRLSGSRHFRQRVVLATLTSTAITIDDIRSGGA-APGLRPHEVSLLHLLHKISDHHSLDLNETGTKLRYKPGVIVG--GR 83  Japanese rice
YP_054027      2 ISFQQVINFREILLCSTLSERPVKIEFSQY-----PG--PHLQTMLKLLQLIQTGCKIDVNTKG--IIYIPGIITNqdGM 72  Paramecium tetr...
3PQV_A        86 -YTHQCPNSKPVGYFAEPMLYLAPFSKKKFSILFRGITSSHNDAGIDAIKWGLMPIMEKFGV--RECALHTLKRGSPPLG 162 Kluyveromyces l...
P56175        89 -LNHDCCVQRGIGYYLDALIALGPFCKSPLQCTLRGVTNSKDSPSVDHIKGAALSLLKRFLLvdEGLELKVVRRGVAPLG 167 fruit fly
XP_314471     89 -IHHDCSTERGIGYYLDVLVALGPFCKKPLDVTLTGVTNSKESPSVDHIKASALPALKRFLIvdEGLELKVLKRGIMPGG 167 Anopheles gambi...
Q23400        83 -VNLDCGTERCISYFLEPLLLLSPFCKVPMVIKLKGVTNAPGEISVDGMKASWLKVYNKFVLndEKLDIKIQARGLKPEG 161 Caenorhabditis ...
XP_843275     79 -FSHEVPSQRCVTYVIEAALLLLPFAKFDSRITFVGATQGELDLSVDTVRTVTMRWVQLFGV---QGSLRIIRRGAAPGG 154 Leishmania majo...
XP_813340     79 -FSHEVPSCRCVSYIAEVAVLLLPFAKLDTKLTLVGSTQGEMDLSVDTLRTVTTRWLQLFGV---ECSVRIIRRGAHPGG 154 Trypanosoma cru...
XP_640201     79 gITHECGTVRGIGYFVEALICLGPFAKAPLDITLNGITNNDIDLTIDTIRTTTLPIIRKFGIe-EGLIIKIIKRGAPPNG 157 Dictyostelium d...
Q9C578        82 nLVHSCSLSRSIGYYLEPLLLLGLFGKKPLSIRLKGITNDPRDASVDTFRSTTLNIIKRFGVpaEDLELKIEARGVAPNG 161 thale cress
NP_001051811  84 dLEHDCGVHRGIGYFLEPLILLGLFARAPISIRLKGITNDTKDPSVDTFRMVTLHMLKQFGVplEGLELKIESRGAPPLG 163 Japanese rice
YP_054027     73 lQTYNCGAERSISYYLEILLILSLFGKAPLNIELNGLTNDSTDQSVDSIINAYIPLIKKFSp-dWDVSLKVTKRGFL-AG 150 Paramecium tetr...
3PQV_A       163 GGEVHLVVDSLIaQPITMHALDKTMISSIRGVSYSTRVSPSLVNRMIDGAKKVLKSASCEVNITADVWRGENSGKSP--G 240 Kluyveromyces l...
P56175       168 GGEIIFRCPVRK-SLRAIQFQSQGMVKRIRGTVYACKVSPAMANRTVEAAKGCMLKFLPDVYIYTDQNKGKMSGNSP--G 244 fruit fly
XP_314471    168 GGEITFRCPVRK-SLKAIQCTKQTMVKRIRGTAYCCKVSPAMANRAVEHAKGVMLNFLPDVYINTDQHKGKRSGNSP--G 244 Anopheles gambi...
Q23400       162 GGVVVFTAPIVK-TLRPVKRQQVGKVCKIRGQAYVTKVTPSLAYRMIDAAKKAMHGYISDVYITVDQRKGDAGGASP--G 238 Caenorhabditis ...
XP_843275    155 GGAVELDIKAIR-RLTSATTKERGRVRRVRGIAFASRTAADLPQRTATAAKGELLKLLPDVYVVTDVDNSKANRNDRvsG 233 Leishmania majo...
XP_813340    155 GGAIELQCKALR-KLTSVDATTRGRVRRIRGISFGSRVAADLAHRAATAAKGVLLNLLPDVYVVTDLDNSKTHHGEPssG 233 Trypanosoma cru...
XP_640201    158 GGSVNFKCPIVP-HLKAIQLIDEGKIRRIRGIAYATRISPQFSNRVLDKAKGLLLEYTPDVYISSDHYKGNESGLSP--G 234 Dictyostelium d...
Q9C578       162 GGEVLLTVPNIK-TLSAVHWVEEGMVKKIRGTTFSTRVTSDFEHSMRFAARGIFNNLLPDVHIFQDHRAGAQAGKSP--G 238 thale cress
NP_001051811 164 GGEVFLRVPNIKsTLKAANWADEGMVKRIRGVSFSTRVSPQIENRIIYAARGIFNRFIPDVHIFTDHRSGSAGGRSA--G 241 Japanese rice
YP_054027    151 TGTIILHSKPIK-QIQNTTIIERGPICKIRGVCSGSKVAPNLLNRVVGQCRNVFNDYIPDVWIHTDLQKSQKGIEFQs-G 228 Paramecium tetr...
3PQV_A       241 WGLTLVAENKQ-GWRIFSEAIGDA-------------GD--VPEDIGASVAYHLLEEISKSGVVGRNQLPLTILYMIIGK 304 Kluyveromyces l...
P56175       245 FGICLIAETTD-GVCFAADCCSNTree--------seDTpsIPENLGKEVALRLLDEIYRGGCVDSSYQWLAALYIALGQ 315 fruit fly
XP_314471    245 YGINLVAETTD-GTMFSAEAICKTmde--------qqGNpsIPEDLGREAGMKLLDEVFRGGCVDSAFQWLVVLYMALAQ 315 Anopheles gambi...
Q23400       239 YGLFLTAETTE-GVIYQAEAISRPkg---------esGVpiLPEDIGIEAGHALLQQIYMGGALDSSAQILASTFMTLCP 308 Caenorhabditis ...
XP_843275    234 YGVVLVAETTSkLCVISQESVAMPq---------------eSPEDVGKRAAQLLFDQIYEGGCVDAHHQMLVLLLMALSP 298 Leishmania majo...
XP_813340    234 YGVLLVAETTSkHCVISQEATAAPr---------------ePPEAVGKRAAELLLDQVFEGGCVDAHHQMLVLILMALSP 298 Trypanosoma cru...
XP_640201    235 YGLTLVAETTT-GCCLSAECMSNTgiatteqqlqkqkSTseTPEDLGERTAFALLEEIFNGGCIDSHNQSLALLFMVLCP 313 Dictyostelium d...
Q9C578       239 YGISLAAETTT-GCFISADTTVSCerpdetgeldvekKErsPAEDTGVEVASWLLQEIEKGGVVDSTHQGLLFLLCALSE 317 thale cress
NP_001051811 242 YGVSVVAETTT-GCLLSADATVSYpnvdem-neesenLEltSPEDLGVQVASMLLEEVAQGGVVDSAHQGLLFILCALSP 319 Japanese rice
YP_054027    229 YAVSLVAESTN-GLFISCDCEYSN--------------DlnNPEKVGEAAALRLLDEIKNCGCCDTTQQQFALLLMAISQ 293 Paramecium tetr...
3PQV_A       305 EDIGRLRITkdQIDERFVWLLRDIKKVFGTEILLKPV--D-------------DNTTDLIATIKGIGFTNTNKKIA 365 Kluyveromyces lactis
P56175       316 KHVSKFLTG--ALSNYTVHFLQHLRDFFSITFKLENPeaEdede-----aenvRGAQKVLMACVGIGYTNINKRVI 384 fruit fly
XP_314471    316 KDVSKFLIG--PLSQYTIHFLQHLREFFAITFKLENAngDqedetagrddeelSGSNKVMLTCVGVGYSNFSKRVN 389 Anopheles gambiae s...
Q23400       309 KDVSHFLYG--PLPMYSVHALRHLKQFFEIEFKMEDFkkTlkeee---adlktGSADKAMVTAVGVGYSNLNKTIL 379 Caenorhabditis elegans
XP_843275    299 DEISTVRFG--QLSASGVSALMLMDSYFGVSCAVKPDssFag----------pNLPLTTLVTCLGSNAVNVWKKSS 362 Leishmania major st...
XP_813340    299 DEVSTVRFG--QLTGSAVSAVMLLEAYFGVVCATKEElsMtg----------eNAPSSTLITCVGSNTVNVWKKSG 362 Trypanosoma cruzi s...
XP_640201    314 EDISKVRLG--KITPYTIEFIRQLRDFFGVTFKIEPD----------------QNSKTVLFTCLGIGYKNMARSTF 371 Dictyostelium disco...
Q9C578       318 QDVSKVRVG--TLSPYAVETLRNIKEFLGVKFAIKPD----------------PLTGTVILKCTGSGLINLSRKLS 375 thale cress
NP_001051811 320 PDVSKVRVG--QLTPYAIETLRNIRDFLDVKFIIKPD----------------PNSNTVTLKCVGAGVKNLARKTS 377 Japanese rice
YP_054027    294 RKVSQIKLG--RISTHTIETLRIIRSIFGVTFNIEDS----------------------VFSCIGCGLMNLSRQTQ 345 Paramecium tetraurelia
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