4A90


Conserved Protein Domain Family
SAP18

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pfam06487: SAP18 
Sin3 associated polypeptide p18 (SAP18)
This family consists of several eukaryotic Sin3 associated polypeptide p18 (SAP18) sequences. SAP18 is known to be a component of the Sin3-containing complex which is responsible for the repression of transcription via the modification of histone polypeptides. SAP18 is also present in the ASAP complex which is thought to be involved in the regulation of splicing during the execution of programmed cell death.
Statistics
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PSSM-Id: 461934
Aligned: 112 rows
Threshold Bit Score: 83.3527
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4A90_A         20 IDREKTCPLLLRVF-TtNNGRHHRMDEFS---RGnVPs----SELQIYTWMDATLKELTSLVKEV------YPEARKK-- 83  
KDE08646       58 VKRSTTVPSLLRVFvS-RTPQHHDEALFSspdGTgPArsilqDEYQLYVWRDSTLKELVHALASSft---lPTTPPNI-- 131 
CEL63934       10 VDRTKKPPFLLRTF-V-RSGGFHPETAFD---NGrVPt---lDEHAVHVWSDSTLIDIVRALRAQ-------TPSPSLpa 74  
XP_007392463   12 VDREKTAPFLIRTF-I-KVGTFHRLQQFE---DAaAPt---aDEQQLYTWKDATLREVLTTLRSIapatpeYRHPLA--- 80  
EMD40331       12 VDREKTAPFLIRTF-I-KIGSFHRLTQFD---DGsVPi---aDEQQIFTWKDATLREVLTTLRATapaspeYRHPLA--- 80  
EGO02292       13 VSREKTAPFLIRAF-V-KTGGFHRLALFE---EGsLPt---tDEQQIFTWKDATLREVLTTLRNTapptpeFRHPLA--- 81  
EEB94277       21 VSREKTAPFLIRTF-V-KIGGFHRLSLFE---DGtLPt---tDEQQLFTWKDATLREVLTTLRNTaphvpeYRHPLA--- 89  
EAU82654       14 VARDKTAPFLIRTF-V-KIGGFHRLTLFE---DGtLPt---tDEHQIFTWRDATLKEILTTLRNTsphvaeFKHPLA--- 82  
EIM20431        4 seldiHCPRLIRVF-V-RTTQPYDAYSFD----KgLPs---kDEYDILAGPNTTIRELLLLLQKSlp---eNLRHPRS-- 69  
CCF54524        7 spgddATPFLLRVF-V-KPVPFRSLEDFHs--EGrLSr----DEFKLHVWKTNTLREVAQMLYDAd----tCISTPLA-- 72  
4A90_A         84 ------GTHFNFAIVFMDlKr--PGYRVKEIG------------------STMSGRKGt---DDs--------------- 119 
KDE08646      132 --------RYSFKLVYYD-Aqs-sRHRSKPIGllt-------------nrDIFHSTKSttgtAPg--------------- 173 
CEL63934       75 gafrnpSTRYSFRVVYYD-R---GNVASRDLGqvgpre-------lndisGLYPSSGGqtptPPteptdlpadsamdadd 143 
XP_007392463   81 --------RYTFRAIYAD-SasrGRIAQKDLG------------------TVYSRDILgepgTLqapaprllad------ 127 
EMD40331       81 --------RYSFRALYAD-SaarGRVAQKDLG------------------LVYSRDILgepgSLaspaprllsd------ 127 
EGO02292       82 --------RYSFRAIYAD-SanrGRFAQKELG------------------IVYSRDILgepgTIdspaprlledtdg--- 131 
EEB94277       90 --------RFSFRTVYAD-StnkGRFASKELG------------------MVYSRDILgepgSTtstaprlledvdn--- 139 
EAU82654       83 --------RFSFKAVYAD-SaskGRFTQKDLG------------------MVYSRDILgepgSHgvtaprllledeeggg 135 
EIM20431       70 --------IYGVHSIYVD-Mks-mYHKERDLGr----------------ySLSVKNYSdkydDQ---------------- 107 
CCF54524       73 --------LHAFRRIHRS-ErlpGDFEATPIGvgitrvplasvsallsdlDTPDKDRMdtdtPEqrqnkahdrvstskll 143 
4A90_A        120 -----------------------------MTLQSQKFQIgDYLDI 135 
KDE08646      174 ----------------------------dKTLHQTSWVVgDYLSI 190 
CEL63934      144 dsprkdrddedvltagattrggsrsksgsRTLDELRVKPgDWLSV 188 
XP_007392463  128 --------------------tdappgdeeRTLDELRFVPgDYMCV 152 
EMD40331      128 --------------------adapppadeRTLDELRFVPgDYLCV 152 
EGO02292      132 -----------------earepserereaRTLEELRFVPgDYLCI 159 
EEB94277      140 -----------------esrelterereeRTLDELRFVPgDYLLV 167 
EAU82654      136 g-----------aaanrdsehpvprereeRTLDDLRFVPgDYIMV 169 
EIM20431      108 -----------------------------STLDEARIYPgDYLSV 123 
CCF54524      144 --------------aldllqdeidenaaaITLAELNLVDgDMLDC 174 
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