6NWX


Conserved Protein Domain Family
GILT

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pfam03227: GILT 
Gamma interferon inducible lysosomal thiol reductase (GILT)
This family includes the two characterized human gamma-interferon-inducible lysosomal thiol reductase (GILT) sequences: Swiss:P13284 and Swiss:Q9UL08. It also contains several other eukaryotic putative proteins with similarity to GILT. The aligned region contains three conserved cysteine residues. In addition, the two GILT sequences possess a C-X(2)-C motif that is shared by some of the other sequences in the family. This motif is thought to be associated with disulphide bond reduction.
Statistics
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PSSM-Id: 460853
Aligned: 158 rows
Threshold Bit Score: 57.3402
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6NWX_A        15 SLYYESLCGACRYFLVRDLFPTW--L-MvmeIMNITLVPYG-NAQERNVSGTw-eFTCQHGELECRLNMVEACLLD---K 86 
Q7PR47         3 VYYAHLCPDSVRWVQNQLLTLNPtlLnA---ITLDFIPFGK-AQSVNNGQSF---ICQHGPAECEGNRVQSCVLSL---L 72  Anopheles gambi...
EPT03814      46 VLGVMSRCPDAVLC-EAVFDQVLk---KvgnKIDLSLTFVA--HANISEPdf--gVTCKHGPTECAGNVHELCAMK---Y 114
XP_007329479  38 QLGVMSKCPDALLC-ESTFNEVLg---KvgdKMDLSLVYVA--KFDESEPdf-ggIICKHGAEECAGNVQQLCIAK---Y 107
EDR12404      42 QLGVMSRCPDALLC-ESRFNQVLd---QvsdKVDLSLVYVA--KLDSSQPdf--gVWCMHGPDECAGNVQQLCVAK---Y 110
XP_007416000  50 TLIVMSQCPEAKKC-QKAIDEALi---KlgdKMDVEVGYVA--KLNSSSRf---gVTCFHGDTECEGNIQQLCYkarfpf 120
A0BYJ1        24 KIYIESRCPDTAAMMRGISNATId---SldqLANVEFIPSG-KLNSNSYEANtyiTNCQHSEEECYGNMILACGLQ---L 96  Paramecium tetr...
A0CWN1        19 DIFIESQCPDTVRLFK-RMKTLLdyE-QineYVQFNFIPFG-KGNEKLVLNKgyeFNCQHGNKECYGNLIDSCVLE---Q 92  Paramecium tetr...
EDO41893       7 AVYYNSKNPEFRRFMVAQLYPTSn---KipnILDISMVPFG-DGKEIKAKSGf-qYYCTNGAEECLENLIQACAVA---T 78 
EEY53139     145 EMYWRAFCPGCMSFITKPLLSLIrnK-EfqeIIDFRPVPAAgTSFDAKGn-----FVCTAGMVECLGHKWLSCAVE---E 215
6NWX_A        87 LEK-EAAFLTIVCMEEmd-------dM--EKKlg------pCLQ 114
Q7PR47        73 PTQqAQVNYVGCQMSF----------TadPRGwe------cAFR 100 Anopheles gambiae str. PEST
EPT03814     115 Asp-saFWEFVQCQNYqgl-----ekIgqPETal------kCAS 146
XP_007329479 108 Asp-dqWWNFVQCQNFegt-----aqIgkPSVal------kCAE 139
EDR12404     111 App-enWWEFVQCQNYqgr-----enIgdSDVal------kCAK 142
XP_007416000 121 fKD---WWSFIQCQTSnplg---skhIgtKSLle------kCIK 152
A0BYJ1        97 QKDqVSSTKFVRCFFKeayk-------qnfQEqi-----dkCLE 128 Paramecium tetraurelia
A0CWN1        93 L-DqIEQLRYLTCIHQekqnneelinLslKk----------CVQ 125 Paramecium tetraurelia
EDO41893      79 ENNpEILTSFVGCLSY--------------YDgsvdkiakyCSN 108
EEY53139     216 FHQiGDLVERIACMESkdnkgmtwsfIinR-----------CFE 248
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