Conserved Protein Domain Family
Mic1

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pfam07035: Mic1 
Colon cancer-associated protein Mic1-like
This family represents the C-terminus (approximately 160 residues) of a number of proteins that resemble colon cancer-associated protein Mic1.
Statistics
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PSSM-Id: 429257
Aligned: 22 rows
Threshold Bit Score: 177.044
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001748829 515 SRRFLIRAVTEYIRSLS-LAEVPVEHLIYEMLINMLVSGKQFYQLHQFFQYHVFDDSEPMACFLLSLQM-QYPPAYQLAM 592 
XP_004924172 460 DDRHLVQVVTAYLASLS-RQELVVQSGTSAAGVRALVARRASGRLRALVRRAALADSRPLACQLLSLHR-LHAAAAQLAL 537 
OWR41468     455 sHTLLVQVVTAYLSSLS-RYELVVQHAVCELVVRSLVRAGEGGRLRALVRRGALQDGRPLACQLLSLGH-LDPAAAQVAL 532 
ETN59849     476 dtpQLGKILLLYLNSLA-RHGISTNHELSKALLIDLVEHRQFDTLQLLLKHSALNESKALACFLLSLSNaAYPIVSQMAL 554 
XP_001841968 464 DSEQLGKILLLYLHSLA-KHGITANHELSKQIVIDLVKNKQFDTLQQLLKYSALNESKPLACFLLSLSN-SHPSISQMAL 541 
1_pfamImport   1 EKPFTEDILMVYLQSLS-KYKIPAEDEISKMIIKELIRNENYKTLLLLVEFSLICETKSMACFLLSYSK-LSPIINQTAL 78  
Q9VRX1       461 RRPYTESILMLYLQSLN-KFNIAAQEELSKMIISELISNRSFDTLRRLVSYSMLLESKSVACFLLSHSN-VDTAISQVAI 538  fruit fly
Q95Y58       445 PESYVANIMLQYLRSLF-DAEITPEAYLIEMVVETLAEAGEMSKLQQIVTYRVINDSKPLAFLLLSYEA-RCSTLFQSGV 522  Caenorhabditis...
EMS47948     621 DPAYLIAVIMEFLRSLS-KAGLKAPPDLYVMMTALLACSNRYAEIALFVSNKILEPSRELAMQLIDLGR-HHSLTRKLGV 698 
Q54LC7       739 DSKYLIAVVIQYIKSLSfNHCTGISDKLYNLLISLLIDNNMFSRLHQFLQYYVITDSLSIAYKLLSIGE-QYPPVLQLSL 817  Dictyostelium ...
XP_001748829 593 DMFKRIeSDPVKICDILLTCGFVLPALRYIKSFGrdIVGRVPAK---------RFLEAALASNDDMLFYNVYNFFIMRNV 663 
XP_004924172 538 DMLWRL-KGHEEVVEVLLSWEEPISAVGAAKQAGgnVWNNLPAR---------KLLAGAK--NDPSAFVAVYHALLNRND 605 
OWR41468     533 DMMWRL-RAYGEIVEVLLSREEPVSAAGAARQAG--AWGSLAAR---------KLLSAAQQHSRPETFLAIYHALRTRNE 600 
ETN59849     555 DMLSRL-NANEIILEVLLERGQIIDALRLAKQMP--GAESLPAR---------KYLEAAYRTNDSLIFHSVFNFFQMKNV 622 
XP_001841968 542 DMLARL-NANEIILEVLLEKGQVIEALRIAKQMP--GADSLPAR---------KYLEAASKTQDALVFHSVYAFFQAKNI 609 
1_pfamImport  79 DMLRKI-SANEIILEVLLEHGQVIDALRIAKSLP--NSDSISAR---------KYLEAAQKSGDANIFYNVFKYFQQRNL 146 
Q9VRX1       539 DMLGRI-EAHEIIIEVMLGQGKVIDALRLAKNSM--GLEKVPAR---------KFLEAAHKTKDDLIFHSVYRFFQMRNL 606  fruit fly
Q95Y58       523 DILARN-KASDEIVEVMLEKKQIVDAFRFIDVRN--LNDALIP----------KVVEAANQHCVRQTRYAIKEHLTEKKA 589  Caenorhabditis...
EMS47948     699 DMLRER-CLHHDYVAALLQDGYYLEALRYARKYK---VITVQPS---------LFLEEAVAKNITPNLAAVLSFFAEL-- 763 
Q54LC7       818 DMFKRL-SMPNIIIETLLERGQVIQAIRLLRSTK--ETNEQAYQelltptypiQFLASSSNQSNDTLFFSVFKFFETNNL 894  Dictyostelium ...
XP_001748829 664 TLRNKSAFLPD 674 
XP_004924172 606 RLRGSPHFLKA 616 
OWR41468     601 RLRGTPDFLTE 611 
ETN59849     623 RLRGSPDFLKH 633 
XP_001841968 610 RLRGSPDFLKH 620 
1_pfamImport 147 KQRGKVDF--- 154 
Q9VRX1       607 KLYETLSFPKG 617  fruit fly
Q95Y58       590 KASLYKSIGDE 600  Caenorhabditis elegans
EMS47948     764 ----TPSFKtt 770 
Q54LC7       895 IIPSHPSFDKy 905  Dictyostelium discoideum
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