6IQ5,3PM0


Conserved Protein Domain Family
CYP1B1-like

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cd20675: CYP1B1-like 
Click on image for an interactive view with Cn3D
cytochrome P450 family 1, subfamily B, polypeptide 1 and similar cytochrome P450s
Cytochrome P450 1B1 (CYP1B1) is expressed in liver and extrahepatic tissues where it carries out the metabolism of numerous xenobiotics, including metabolic activation of polycyclic aromatic hydrocarbons. It is also important in regulating endogenous metabolic pathways, including the metabolism of steroid hormones, fatty acids, melatonin, and vitamins. CYP1B1 is overexpressed in a wide variety of tumors and is associated with angiogenesis. It is also associated with adipogenesis, obesity, hypertension, and atherosclerosis. It is therefore a target for the treatment of metabolic diseases and cancer. Also included in this subfamily are CYP1C proteins from fish, birds and amphibians. The CYP1B1-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410768
Aligned: 22 rows
Threshold Bit Score: 759.925
Created: 18-Jul-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingchemical
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Structure:6IQ5: Human cytochrome P450 1B1 binds heme; contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                            #              ##       #   #      #        
6IQ5_A        14 YGDVFQIRLGscPIVVLNgERAIHQALVQQGSAFADRPSFASFrvVSGGRSMAFGHYseHWKVQRRAAHSMMRNFftrqp 93  human
AAT07036      67 YGDVFQIKLGsrNVVVLN-GDAIKEALVKKATDFAGRPDFASFrfVSNGKSMAFGNYtpWWKLHRKVAQSTVRNFstani 145 zebrafish
RXM31100       5 YGDVFQIKLGsrNVVVLNgEDTIKQALIKKGTDFAGRPDFISFklVSGGKSLAFGSYsnLWKAHRRIAQSTVRAFstsnp 84  sterlet
XP_028676098  77 YGNVFRIKLGnrVVVVLNgEDAIKEALIKKGVDFAGRPDFTSFkvISGGKGMAFNDYsdLWKIHRKVAHSTIRHFstcnh 156 reedfish
XP_007892109  76 YGNVFQIKLGsrSVVVLNgEECIREALVRKAEQFSGRPDFASFneVSGGRSLAFRSYcdRWKFHRRIAHSTVRAFstnnp 155 elephant shark
AFB82731      76 YGNVFQIRLGnqDIVVLNgDSTIREALVKHSKEFAGRPNFSSFqlISGGKSIAFGGYstLWKAQKKIAHSTLRAFstvnt 155 African clawed ...
XP_020378525  92 YGSVFRLKLGshTVVVLNgEESIRQALVRQGADFSGRPDFSSFavVSGGRSLAFRSHgdLWRLHRKVAHSTVRAFstsnl 171 whale shark
NP_001296383  78 YGAIFQLRLGrhRVVVLNgEAAIRRALVGLGTRFAGRPDFPSFglVSGGRSIAFGGCtpQWRARRRLAHAALRAHstv-- 155 chicken
XP_012672544  74 YGDVFQIKLGsrTVVVLN-GDAIKQALVKKGVDFAGRPNFTSFqfVSNGKSMAFGDYneWWRVHRRIAHSTVRAFssgnt 152 Atlantic herring
XP_028844736  67 YGDVFQIRLGsrAVVVLN-GDAIRRALVQKGADFAGRPDFTSFrvVSDGRSMAFGDYgpRWKLHRRVAHAAVRALsagda 145 denticle herring
Feature 1                                                                                        
6IQ5_A        94 rsrqvLEGHVLSEARELVALLVRGsadgafldPRPLTVVAVANVMSAVCFGCRyshddPEFRELLSHNEEFGRTVGAGSL 173 human
AAT07036     146 qtkqtFEKHIVSEIGELIRLFLNKsreqqffqPHRYLVVSVANTMSAVCFGNRyayddAEFQQVVGRNDQFTKTVGAGSM 225 zebrafish
RXM31100      85 qtkkaFEQHIISEIRELVKVFLKKtkqekyfrPSQILTVATANIISALCFGKRysyedVEFKSVVGRNNQFTETVGAGSL 164 sterlet
XP_028676098 157 earksFEQGILSEIKEVIGVFLKKsedekffeAGTFLAVAVANTMSAVCFGKRysyddAEFQSLIGRNDQFAKTVGAGSI 236 reedfish
XP_007892109 156 dtkktFQRHVVGEVQQLIQLFVEKsqsagyfnPTSNLVVAVANVMSAFCFGKRyshddQEFLSLLSKNDQFGKTVGAGSL 235 elephant shark
AFB82731     156 ktqnlFEKHVAAEAQDLIRVFLRLtseeqyfdPTRECTVAAANVICALCFGKRyshddEEFKALIGRNDKFGQTVGAGSL 235 African clawed ...
XP_020378525 172 etkkvFEQHVVCEMQQLISVFMDRgplghyfdPWPNLVVAVANVMSAVCFGKRyshddQEFTSLLAKNDRFGQTVGAGSL 251 whale shark
NP_001296383 156 ---aeVERHVVAEAGDLVRLFLRHsqggayfqPCPLLVVANANVLCALCFGRRydhadGEFTALLGRNDRFGQTVGAGSL 232 chicken
XP_012672544 153 htkkaFENHAMNEMRELVNIFLSKtaeqgyfiPHQYLVTSTANIMSAVCFGDRysyddKEFQQVVGRNDKFTETVGAGSM 232 Atlantic herring
XP_028844736 146 rarasFERHVLSEVTLLLRRFLRRtaeetffqPHADCLVSTANIMSALCFGSRyshddREFRQVVGRNADFTRTVGAGSI 225 denticle herring
Feature 1                                                                                        
6IQ5_A       174 VDVMPWLQyfpnpvRTVFREFEQLNRNFSNFILDKFLRHCeslrpgaapRDMMDAFILSAekkaagdshgggarLDLENV 253 human
AAT07036     226 VDVMPWMQyfpnpiRTLFDQFKELNKEFCAFIELKVSEHRktis-pshvRDMTDAFIVALdkglsg---gsgvsLDKEFV 301 zebrafish
RXM31100     165 VDVMPWLQsfpnpiKTMFGNFKNLNLEFFAFIEDKVTQHRatik-pgiiRDMTDAFILALdqgkrg---tngvlLGKEHV 240 sterlet
XP_028676098 237 VDVMPWLQsfpnpiKTMFDNFKTLNEEFYDFIYGKVVQHRatlk-agtiRDMTDAFIVALdqgkev---kngavLGKEHV 312 reedfish
XP_007892109 236 VDVMPWLQyfpnpvRAVFENFKGLNRDFYTFIRDKALQHRetfr-adtvRDIMDAFIQIIdyektv--sdkgvkLEREYV 312 elephant shark
AFB82731     236 VDIMPWLLtfpnpvRSLYQSFKDLNWEFYDFVKEKISHHRqtyk-peitRDMSDAFISHIeqaee-----aghgLSKDYV 309 African clawed ...
XP_020378525 252 VDIIPWLQyfpnpvRSIYQDFEQLNRDFYLFVQDKARQHRldfr-pgrvRDMMDAFIHTIehgrva--sdtgliLSPDYA 328 whale shark
NP_001296383 233 VDVLPWLLrfpnpvRHVYRDFQALNRELHGFVQAKVAQHRqtfd-wravRDISDVMIASVerggg-----spdgLGPEDV 306 chicken
XP_012672544 233 VDVMPWLQyfpnpiRTLFEQFRELNVEFHDFIMGKVTEHRktie-agiiRDMTDAFIQALdkgisg---plgvvSGKEYV 308 Atlantic herring
XP_028844736 226 VDVMPWLQyfpnpiQTLYRQFTELNREFSGFVRGKVAEHRrsaa-agvtRDMTDALIFALdkglgg---aagafLGGEYV 301 denticle herring
Feature 1              #  ##  ##                                                          ##  ## 
6IQ5_A       254 PATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGrdrlpcmgDQPNLPYVLAFLYEAMRFSSFVPVTIP 333 human
AAT07036     302 PPTISDIFGASQDTLSTALQWIILLLVRYPEIQKRLQEDVDRVVDrsrlptiaDQPHLPYLMAFIYEVMRFTSFTPLTIP 381 zebrafish
RXM31100     241 PPTVCDIFGASQDTLSTALQWIVLLLIRFPEMQTRLQQEVDNVVDrtrlpsieDQPSLPYVMAFIYEAMRFSSFMPGTIP 320 sterlet
XP_028676098 313 PPTVNDIFGASQDTLSTAMHWMFRLLVRFPDVQEKLQKEIDEVVGrnrlpcieDQQNLPNVVAFIFETMRFSSFVPVTIP 392 reedfish
XP_007892109 313 DSTVTDIFGASQDTLSTALTWIILFLVWRSDVQERLQHEMDRVLGrdriptidDKPHMPYLTAFLFESLRFSSFVPITIP 392 elephant shark
AFB82731     310 ESIVNDILGAGQDTTATALTWILLLLIKYPDIQQKLRDEIDLVVGpnrlpsadDKVHLPYVQAFIYETLRFSSFVPVTIP 389 African clawed ...
XP_020378525 329 DSTVTDIFGASQDTLSTALHWITLYLVWQPQVQAKIHEELDRVVGrqripsieDQPRMPYLMAFLYETLRFSSFVSLTIP 408 whale shark
NP_001296383 307 EGAMTDIFGAGQDTTSTALSWIILLLLKHPQVQQDLQAELDRVVGrsrlptaeDRPHLPLLEAFIYETLRYSSFVPITIP 386 chicken
XP_012672544 309 SPTISDIFGASQDTLSTALQWIFVILLRYPEIQKRLRDEVDQVVQrtqlpsieDQERLPYVMAFIYEVMRYTSFVPVTIP 388 Atlantic herring
XP_028844736 302 SPTISDIFGASQDTLSTALHWIVLILVRYPEVQTQLRVEVDKVVArsrlptieDQARLPYVMAFIYEVMRFTSFVPITIP 381 denticle herring
Feature 1        #                      #                                     ###   # ###   #    
6IQ5_A       334 HATTANTSVLGYHIPKDTVVFVNQWSVNhDPVKWpNPENFDPARFLdkDGLINKDLTsrvMIFSVGKRRCIGEELSKMQL 413 human
AAT07036     382 HSTTKDTSINGYPIPKDTVIFVNQWSLNhDPTKWdQPEVFNPQRFLdeDGSLNKDLTtnvLIFSLGKRRCIGEDVSKIQL 461 zebrafish
RXM31100     321 HSTTTDTSVNGYHIPKNTVIFINQWSVNhNAQKWaNPGVFDPTRFVskTGDLNKDLTnsvLIFSVGKRRCIGEELSKMQL 400 sterlet
XP_028676098 393 HATTVDTSVMGYHIPKNTVVFINQWSVNhDPQKWsNPDVFDPTRFLdeNGTLNKDLIssvMIFSVGKRRCIGDELSKMVL 472 reedfish
XP_007892109 393 HCTTTDTQLNGYHIAKDTVVFVNQWSVNhDPDKWlQPETFDPGRFLneNGSLNQDLLssvMIFSLGKRRCIGDELSKMQL 472 elephant shark
AFB82731     390 HSTTSDVLIDGFYIPQDTVVFVNQWSVNhDGSKWkNPEVFDPSRFLdeDGQMDRDAAfgvMIFSVGKRRCIGDQLSMLQI 469 African clawed ...
XP_020378525 409 HATTRPTLLSGYRIDKGTVVFINQWSVNhDPHKWhQPEVFDPCRFLteAGTFNKDLAsqvMIFSLGRRRCIGDELAKMQL 488 whale shark
NP_001296383 387 HATTADVELEGFRIPKGTVVFVNQWSVNhDCSKWpEPQRFDPTRFLdkQQRLDRERAgsvMIFSAGQRRCIGDQLSKLQI 466 chicken
XP_012672544 389 HSTTSDTSINGYRIPKNTVIFVNQWSSNhNPKRWtRPEVFDPLRFLdeSGALDKDQTsnvLIFSVGKRRCIGEDLAKMHL 468 Atlantic herring
XP_028844736 382 HSTTSDTSIDGYHIPKNTVVFINQWSNNhNPAKWdRPEVFNPLRFMsqDDVLDKDLAsnvLIFSVGKRRCIGEDLSKIQL 461 denticle herring
Feature 1                                              
6IQ5_A       414 FLFISILAHQCDfranPNEPAKMNFSYGLTIKPKSFKV 451 human
AAT07036     462 FLFTSVLVHQCSf--kAESTPNMDYEYGLTLKPKPFKV 497 zebrafish
RXM31100     401 FLYTAILAHQCNfianPDEPSTLDSCYGLTLKPTPFSI 438 sterlet
XP_028676098 473 FLFVSVLLHQCKftadPNGSRTIESFYGLTLKPKPFKI 510 reedfish
XP_007892109 473 FLFTSILMHQCTitgnPTEELTLDFDYGLTLKPKPFSI 510 elephant shark
AFB82731     470 FLFTTIFLHQCTfqgnPKEIPTMDCTSGLALKPLPYGM 507 African clawed frog
XP_020378525 489 FLSTSLLMHQCTfranPKEELTLDFTYGLSLKPKPFTI 526 whale shark
NP_001296383 467 FLFTAILLHQCSfhanPAEHLTMDCIHGLALKPLPFTV 504 chicken
XP_012672544 469 FLFTSLMVHQCEmkadPSRPISMDYSYGLTLKPKSYRV 506 Atlantic herring
XP_028844736 462 FLFTSLLVHQCTftadPSQPLRLDYEYGLTLKPNPYRI 499 denticle herring

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