2C91,2CLP,2BP1,1GVE


Conserved Protein Domain Family
AKR_AKR7A1-5

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cd19075: AKR_AKR7A1-5 
Click on image for an interactive view with Cn3D
AKR7A family of aldo-keto reductase (AKR)
Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Statistics
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PSSM-Id: 381301
Aligned: 65 rows
Threshold Bit Score: 350.703
Created: 8-Mar-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitecatalytic
Conserved site includes 36 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2C91: Mus musculus succinic semialdehyde reductase (AKR7A5) in complex with cofactor NADP and tartaric acid, contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          ###              #                     #    #                           #  
2C91_A     17 PATVLGTMem----------grRMDASASAASVRAFLERGhSELDTAFMYcdGQSENILGGLGLglgsgdcTVKIATKAN 86  house mouse
PNS21549    7 VKIVLGGSli-----------sDWKADDKEEYGRLIKHYNiWDVDTSIIY--QQSETVLGELQAt-----lPLRVHTKTP 68  Elsinoe sp. CQ-2017a
SCU84776    6 PKVVYGAYpl-----------aTLSQEDRDAVYKILDKHNiAELDTARIY--PGSEEALGKQDAg-----kKYKIDTKAA 67  Lachancea sp. PJ-2...
KXG46841   10 VALAGGTHtwv---------ptPKSEATQDEVVAIMQEHGiTNLDTARSYgmGASEETIGNKNLg-----aEFSVWTKAP 75  Penicillium griseo...
POF26221    6 IQTIYGGAairp-------dygFGKPERLEQVFSILTAAGvKTIDTAALY--GPSEELLGQAHVg-----eKFTVDTKTK 71  Quercus suber
Q6Q875     10 PIIIFGTAnfgspedskgklfgPVTVEQGREYLDVLQEFNvDVLDTARIYsgGESEKLLGALDAs-----rEFKMCTKAS 84  Leptosphaeria macu...
EXJ82863   23 IEIIIGGPilgp-------qseYATASKLEALVSLCQSHSiTAIDEAKIY--AASEAFVGATRLga----qGFRIDTKTP 89  Capronia epimyces ...
CZR63220    7 SHLVFGVGhwn---------ndPANLSEQQEMLAMCRKHGiDTFDVARHYshGESEKFLGNEGLs-----sEFKIITKAP 72  Phialocephala suba...
KIW05170   10 VKISVGMMgssva----agspsLATPAQVSAFLDVVRSHGvRELDTARVYndGKSEELLGEVQAh-----kDFLIATKAP 80  Ochroconis gallopava
POE77449    2 PKIIVGLMggsv------kagsAATSTDLAPFLAMLKAHAvHELDTARVYnaGRSEESLGQLPDaq----kDFSIHTKAP 71  Quercus suber
Feature 1      #                                 #                                            
2C91_A     87 PWegks--lkpDSIRSQLETSLKRLqcPRVDLFYLHAPDh-sTPVEETLCACHQLHQEG----------------KFVEL 147 house mouse
PNS21549   69 GFkkgi--ltrDAVLASARQSASRV--KDIDTYFLQTPDp-dTRMEEYVGAIADLYNEG----------------LFKRF 127 Elsinoe sp. CQ-2017a
SCU84776   68 GFsens--nndAGIRKSIKESLELLklDKVYIYYLHSPDp-sTPLEETLATINELYKAG----------------KFEKF 128 Lachancea sp. PJ-2...
KXG46841   76 TGlggg-agkrENILEQGRKSNVVLrlSKIPVYLLHAPDe-sVPVAETLGAIQTLYEEG----------------RFEKF 137 Penicillium griseo...
POF26221   72 GSfvtqdgasrENVIADAKNSRAMLg-TTVDVFYMHSPGhpgTSMEETLKGVKEVYESG----------------FFKRF 134 Quercus suber
Q6Q875     85 GTldgc--gtrDAVLSAFKASSEALgvKEVDTYYLHTPDr-tTSLEETMDTINELHKAG----------------SFKTF 145 Leptosphaeria macu...
EXJ82863   90 GGwepg-sstrAGVVSNLRSSLQRLgvEQAHVFYLHAPDa-aVALDETLAGVNDAHQAG----------------LFSRF 151 Capronia epimyces ...
CZR63220   73 MGlfpn-gstkEGIIEHWEESSKALktDKVAFYLLHCPDd-gTPISETMEGIQTLYEAGhfyevsslsslprpstNKTKF 150 Phialocephala suba...
KIW05170   81 AFtpgs--leyDNIILNCEKSLRALrvNTIDLYYLHGPDp-rTGFEEQCRAINSLHEQK----------------KIDRW 141 Ochroconis gallopava
POE77449   72 GFsags--laySAIMSNCAASLAALqqPQLDLYYFHGPDp-aTPLEESCRAIAQLHAQG----------------KIARF 132 Quercus suber
Feature 1       ##                        #                            #######  # ##          
2C91_A    148 GLSNYaSWEVAEICTLCKsngWILPTVYQGMYNATTRQVEa-ELLPCLRHFgLRFYAYNPLAGGLLTGKYkyedkd--gk 224 house mouse
PNS21549  128 GLSNFsADETLQVYDLCKkngWVLPTVYSGQYSAISRITEd-DLFPVLRKLnIAFWAYWPLAGGFLAKPYesfnvpgreg 206 Elsinoe sp. CQ-2017a
SCU84776  129 GISNYtASDVRKIYEIAKkngYPLPSVYQGNYNAFARKIEd-DLFPVLRELnITFYAYSPIAGGFLARSRqqiee----a 203 Lachancea sp. PJ-2...
KXG46841  138 GLSNMsRDQVLEHYNYAKsqnFILPTVYQASYSIVVRGIEt-NLLSTLRELgISIQAYSPLAAGFLSKTVeqien----g 212 Penicillium griseo...
POF26221  135 GLSNYkAEDVEKMYNLCKeigAPVPSVYQGNYGPVARKQEe-LLFPTLRKLgISFYAYSPLAGGFLTKTKqdie------ 207 Quercus suber
Q6Q875    146 GISNLrADEVQHLHTYARsknYILPTIYQGTYNLLSRQCEt-KLLPLLRTLgIRFYAYSPLCCGLLINAEaklq------ 218 Leptosphaeria macu...
EXJ82863  152 GLSNFpPREVERVYETARangYVLPTVYQGCYSPVTRKPEd-VLLPLLRRLgFSFYAYSPLAGGFLTKTKdqil------ 224 Capronia epimyces ...
CZR63220  151 GISNFsSAQVAELHSYAKskgYILPTVYQAVYSLCSRKNEf-ELFPLLRSLnIKIQAYSALASGFLVKTPsdik------ 223 Phialocephala suba...
KIW05170  142 GISNLtPTQVQEVYSICEknkYPLPTAYQGGYNPINRHQSesNLLPLLKRLnMTFYAYSPLAGGLLAKPTeeivt----p 217 Ochroconis gallopava
POE77449  133 GVSNFsPAHVRQIHDICTrnlWLTPSVYQGGYNALARNPEs-LLLPTLRELgMKFYAFSPLAGGWFSRSDaelre----p 207 Quercus suber
Feature 1        ##      #   #  #                            #                     #####   #  
2C91_A    225 qpvGRFFgn-nWAETYRNRFWkehHFEAIALVEKAlqttygtnAPRMTSAALRWMYHHsqlqgtrgDAVILGMSSLEQLE 303 house mouse
PNS21549  207 fgpGRFSqdyfFSGMFNSIFNkprLLEGLKLWNEVak----deNITPAELAYRWLSFHsil--redDAVIVGSNGPAQLE 280 Elsinoe sp. CQ-2017a
SCU84776  204 aegGRFDpssfIGQMYRQLYAkpsLLKALEEWEQIae----seGISKVSLAYRWVAYHselsgkygDAFILGARTPQQLE 279 Lachancea sp. PJ-2...
KXG46841  213 ngtERWDpnspYGMVNRQLYFkpsYMKMLTEYGKLse----qsGVSKVGLAYRWVRYHsalkgelgDAMIIGANSATQFR 288 Penicillium griseo...
POF26221  208 dgkGRFDpnssMGALYRGLYArpaYLEALEKWEAIak----eeGVTRAELAYRWVKYSsplkpengDGIIIGASSDKQLE 283 Quercus suber
Q6Q875    219 astGRWDtshfGGKFMNALYNkpsYIAASNAFQDMcg----kyGVRPAGAAYRWVRYHselegglgDGMVVGASSARQLE 294 Leptosphaeria macu...
EXJ82863  225 agvGRFNpndmYGAMYRQMFGkpnYLDSLAAWAEIad----qeGVSRAELAYRWVAWSsalneecgDALILGCSSLDQMT 300 Capronia epimyces ...
CZR63220  224 agkGLFDpstvLGKIVQDMYGkpsYLKFLEEYRKLce----evGESPAGLAYRLMVWNsalkveegDIVCLGASSAGQLE 299 Phialocephala suba...
KIW05170  218 kkgTRFD----SMRVFGNMYLneeNIAVLRMLQNAct----aaGISLLEATMRWFMHHspl--genDVVILGASSDSQIA 287 Ochroconis gallopava
POE77449  208 pvgARMQ----QMAAFKDLYVndtSLALHRRLGERcg----aqGVGMKEAALRWLMHHsal--gaeDGVILGGSSTAQME 277 Quercus suber
Feature 1     ##                     
2C91_A    304 QNLAATeeGPLEPAVVEAFDQAW 326 house mouse
PNS21549  281 QVMKSIgsGPLRADSVEKIEHIW 303 Elsinoe sp. CQ-2017a
SCU84776  280 QTLEALaeGPLSAEAAKKVRSLW 302 Lachancea sp. PJ-2012b
KXG46841  289 EAVKEIenGPLEEWIVERIDELW 311 Penicillium griseofulvum
POF26221  284 ETLERLthGPLSEKALKGIDDVW 306 Quercus suber
Q6Q875    295 ESLGEIekGPLEEGLVGELEGLW 317 Leptosphaeria maculans JN3
EXJ82863  301 QAVCGIekGPLSDQAQSAIDALW 323 Capronia epimyces CBS 606.96
CZR63220  300 NTILEVekGKLDDWVVQRLDAMW 322 Phialocephala subalpina
KIW05170  288 ESLRACkkGPLPETLFVAFEEMK 310 Ochroconis gallopava
POE77449  278 ENLVACakGPLPEVLVQEFERLW 300 Quercus suber

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