1W7P


Conserved Protein Domain Family
EAP30

?
pfam04157: EAP30 
EAP30/Vps36 family
This family includes EAP30 as well as the Vps36 protein. Vps36 is involved in Golgi to endosome trafficking. EAP30 is a subunit of the ELL complex. The ELL is an 80-kDa RNA polymerase II transcription factor. ELL interacts with three other proteins to form the complex known as ELL complex. The ELL complex is capable of increasing that catalytic rate of transcription elongation, but is unable to repress initiation of transcription by RNA polymerase II as is the case of ELL. EAP30 is thought to lead to the derepression of ELL's transcriptional inhibitory activity.
Statistics
?
PSSM-Id: 461201
Aligned: 208 rows
Threshold Bit Score: 78.806
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1W7P_A         5 GLAAF-D-E-LKDGKYndvnKTILEKQSVELRDQLMVFQErLVEFAKKHNSELQASPEFRSKFMh--------------M 67  baker's yeast
XP_007374681 113 GIHALeMlDeQQRRQN----EIILSSSLNDLEQLMFKYQD-LIKLSGSFNQFIKPNEHNKRVPTss------------qA 175
CCE43466     318 GIHALeAfGeQQRKNN----EKILGSSLDDLEQLMFKFED-LIKLSSSFKRLLVSKDDKTiy----------------kN 376
EMG50831     300 GIHALeQlGeLQRKEN----ERILSSSLDDLEQLMFKYQD-LLKLSTSFNKLVIKSQDNLnl----------------pV 358
XP_004204396 336 GIHALeKiSeVQRKQN----EMVLASSLEDLEQMMYRAQD-LISLSNIFGRLIEARQVvq------------------gI 392
XP_002175146 220 GVHALqVsHqKQVKQS----GATLTRAFQDLNAFMSLAKQ-TNDLIKNLSQQSKETNLSPTNNDlemtvtrsyfdqfssY 294
EPY53559     225 GIHGLqQsHaLRLAQN----GQTLVRAFQDLDAFFSLTRE-TMELADQFVERIQNLAGFAKQSDrvqql--------lkr 291
CCH62146     307 GISTLeQsReTQLARN----DILLNNALSDLSNLMSFADD-IEKLYSRYNKNDISsskmnskqvpsl------------- 368
CAR26586     336 GITSLeKsGeTQLLNN----DIIFNNALTDLNRLMSLAND-IEQLYTGISPKLLgerkegghkpsl-------------- 396
XP_003678488 306 GITSLeRsReNQLLNN----DILFNNALSDLNSLISLANN-IERLYRSTKNSQQQTNssshriakkpal----------- 369
1W7P_A        68 CSSIGIdplslfdrdkhlftvndFYYEVCLKVIEICRQT---KDMNG------GVISFQELEKVHfr---------klNV 129 baker's yeast
XP_007374681 176 IPSLNLkhs--------------spqELSRHISEYLI--------NYeltttsSMITSQDLFANYnrflintqgfgcdLI 233
CCE43466     377 IPPLTIsrt-----------sklYHSELSRHMSEYLT--------SFvltkksSMITLPDLFAEYnrflvkcsgfgteLV 437
EMG50831     359 IPALNIkkn-----------sslYPQELSRHISEFLI--------NFiltqrtSMISSQDLFAEYnrflirnqgfgtqLV 419
XP_004204396 393 VPPLKIkks-----------sklYHQELSRHISEYLA--------NLqltkssSMVTVQEAFAFYnrylvstqgfgtdLV 453
XP_002175146 295 DVSLT------------------TTTELSKSVAQVLHSYfkkTSC--------AAVTLTVAWAIYnrtr------gidLI 342
EPY53559     292 tqQLGLlrnnyanmvsdssnarlFQVELCKSISELLL--------NHlks-dtDTITMTHAWAMYnrar------kteLV 356
CCH62146     369 -----------ivdrdkfynkniFIEEIAREIYEFATSEfkdEQQREg----cVMISLVDLYAMYnkamr----igvgFV 429
CAR26586     397 -----------ildrekfynkslFLDEIAREIYEFAISEfkaEKERLg----yVMVTLVDLYAMYnkcmr----igtgLI 457
XP_003678488 370 -----------iidrekfynkelFLDEIAREIYDFAMSEfneTTTTTqnenihIMVTLVDFYAIYnksmr----igtgLI 434
1W7P_A       130 GLDDLEKSIDML--KSLE---------CFEIFQirgkkflrsvpNELTSDQtkilEICSIl---------G--------- 180 baker's yeast
XP_007374681 234 KAADFNKSLELFaqLNLPvtmrkyeksGLLVIA-----------KTKLLQE----SYGKYivnfikdqehEyklnkcrhd 298
CCE43466     438 DIVDFRKSIDLFdtLNLPvvsnkyeksELVVI------------RPRVHAN----SYSEFiveflsqqehKykrsfirak 501
EMG50831     420 TSSDFKKAIGLFdeLKLPvilkqytksDIYVV------------SSRSTSN----TYGEFivdylknqeyEykfmklkqe 483
XP_004204396 454 AAEDFGKAVELFdeLKLPfrlqhykksDISVIC-----------YRNSFDN------SKLirdmleeqerSfkynslkak 516
XP_002175146 343 NPSLFLSVCQEMvkMNLGirqi-tfpsGLIVLE-----------LVDDHRS----NVLELimst---------------- 390
EPY53559     357 SPTDFAKACELFptLDLGihvs-klssGVSLFQ-----------LKLPNQRe---KFLSAlldt---------------- 405
CCH62146     430 SPLEMREACESFerLGLTklkltkinqRILCLG-----------SDNALE-----IIKTKivqiieqfpgShllqisk-- 491
CAR26586     458 SPQEMREACERFeeLGLKdlkltkingRVLCLA-----------SKNSFD-----FVKTKildivnesagCdpllltq-- 519
XP_003678488 435 SPLEMKEACQRFekLGLNnlkltrinnRVLCLS-----------TKDSFN-----FVKSQilstidqnpgSdllnltnl- 497
1W7P_A       181 ----------------------YSSISLLkanLGWEAVRSKSALDEMVANGLLW--IDY 215 baker's yeast
XP_007374681 299 mmq-------gvivlehescfrGVTVGEIsstLNWSNNVTIEEVEICVNEGIIV--VDQ 348
CCE43466     502 mvdd-----gdndgldhengcyGATVSEIshaLNWSYNVTMEELDKSIDSGLVV--LDQ 553
EMG50831     484 matg-----devmndlynaagyGKTVSEIstqFNWSYNITIEELDKCVEEGLVV--IDH 535
XP_004204396 517 llaqyqssedsnywherfayfkGSTIPEIcnaLGWSYAITVEEIDTCVEAGLVV--VDK 573
XP_002175146 391 -------------------mkpyTSALECavtLGWPVNVALEHLHQAEIEGSIV--RDM 428
EPY53559     406 -------------------mqptVTISQCamkLHWSIGVTMEQLESAESEGYILppKTT 445
CCH62146     492 ---------------klneysqS----------DWTIGVITEVLQNCIDSGILV--VDE 523
CAR26586     520 ---------------llnrdssN----------AWTFAIITEVLQNCIDHGDIV--IDE 551
XP_003678488 498 ---------------intpstkTANNNKMet-nNWTIGVIMEILQNCVDEGDLL--IDE 538
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap