3R7T,6JRQ


Conserved Protein Domain Family
Adenylsucc_synt

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pfam00709: Adenylsucc_synt 
Adenylosuccinate synthetase
Statistics
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PSSM-Id: 459912
Aligned: 623 rows
Threshold Bit Score: 278.851
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3R7T_A           9 IIVGIQWGDEGKGKVVDKL---CEN-Y-DFVCRSAGGHNAGHTIW-VNGVRYALHLXPSGVLHPRCINIIGNGVVVSPE- 81  Campylobacter...
Q386E7          67 MVVGAFFGDEGKGKTVDAV---ARHpAcTCVARVNSGENAGHTVFdDIGRKYVFNLAPSSLLTPNTRNYVSSECVMDPIs 143 Trypanosoma b...
Q4QG35         173 MVAGAFFGDEGKGKTVDAV---ARHpLcTCIARVNSGENAGHTVYdKAGRKFVFNLAPSGLLLPGKRNYIGPECVMDPVs 249 Leishmania major
Q0JZP8          12 VLVGLQYGDEGKARVVDHL---AGE-Y-EVIARFNGGANAGHTIAtPD-GTLRLRQVPSGVLHPGVALYIGSGCVIGLQ- 84  Cupriavidus n...
Q7N8D4           4 AVVGLQFGDEGKGKFVDYL---SGN-I-NNIARFNGGANAGHCVQhGN-LRGSFSQLPASLNKKNL--YICQGALISLP- 74  Photorhabdus ...
WP_014360712    27 IVVGLGYGDEAKGATVDFLasmIPD-T-TAVVRFSGGAQAAHNVChGS-RHHTFRQFGSASFLDVR-TLLAAPMMVNPL- 101 Gordonia poly...
Q090W1           9 AVVDLGFGDAGKGTLTEWLvrrHGA---RLVVRFNGGAQAGHNVItEDGRHHTFSQFGAGSFVPGVWTHLARTTVLHPL- 84  Stigmatella a...
A8F801           5 AVIGLQWGDEGKGKVVTYL---SRR-Y-DCVVRYSGGSNAGHTVDyGN-FKMVHHLLPSADIKKQKMMYIGPGVVVDLD- 77  Pseudothermot...
jgi:Theth_1863   4 AVIGLQWGDEGKGKVVTYL---SKD-F-DCVVRYSGGSNAGHTVDyGD-FKVVHHLVPSANVKKQKMMYIGSGVVIDLQ- 76 
CDA58485         6 VIVGTQWGNEGKGRIAHQV---SKE-C--IAVRGTGSSKAGHTVM-IGGQKFTLHLLPAAIVLPNTQCIIGPGVVIDLS- 77 
3R7T_A          82 VLIAEXAQFENLKg-----rLYISDrAHLNLKHHSLIDIAkeklkGKnAIG-TTGKGIGPSYADKINR-T-GHRVG---- 149 Campylobacter...
Q386E7         144 FMEREIGQFIKSNmpy-kdkLFVGN-VFVVTPYHKLLDLL-----GS-APNsSTLKGMSPIHASKVTK-R-GIRLD---- 209 Trypanosoma b...
Q4QG35         250 FMEKEVIQLIDAGidy-rdrLFIGN-VCIVTPYHKLLDLL-----GS-AANsSTLKGMAPVHGSKVMK-R-GIRLD---- 315 Leishmania major
Q0JZP8          85 QLAAEIEMLAAQGidl-ggrLTISDrCPVVQPLHVLADRh----dGA-QIG-TTGNGIGPCYADLATR-VrGGERSs--- 153 Cupriavidus n...
Q7N8D4          75 ILVKEIDFIKKEDid---shIFIDPrCHIVLPLHAELNRAsekykGKqKIG-SVGVGVGACVEDKANR-H-GIRLI---- 144 Photorhabdus ...
WP_014360712   102 RVAQEAAELADAGirnpfglLTADArCQVTTPLHIAMNRArealrGNaRHG-STGEGIGETTAYALAV-EsGARRGqrvg 179 Gordonia poly...
Q090W1          85 AMLVEARYLARQGvtdvlgrTTVSEgARLITPFHQAAGRIrelarGEgRHG-TCGVGVGETVRDALAHpAgALHAA---- 159 Stigmatella a...
A8F801          78 VLLEEIDQINN-LipesrslLRISKqAHVVIPIYRDLDEKidssrAN-QIG-TTRRGIGISYANRAMR-C-GLRLE---- 148 Pseudothermot...
jgi:Theth_1863  77 VLLEEIEQLEK-MvpgsrnlLRISNqAHVVLPIYRELDAKidssrLS-TIG-TTRRGIGLSYASKALR-C-GLRLE---- 147
CDA58485        78 ILATEIKTLQAMGvkvsperLIISPrAHIILPYHINMDKMheelkGSnKLG-TTLSGVGPCYSDKVNR-I-GIRMI---- 150
3R7T_A         150 ----------------ELLe-----PQR-LCEALIKDF-----EANKTFFEXLEIe-----------------iPS---A 182 Campylobacter...
Q386E7         210 ----------------HIFn-----DEGvLRARLAKDMdtyygLLKVKGLTDKDVvrrcqeenadgvervpgyvVD---F 265 Trypanosoma b...
Q4QG35         316 ----------------HIFn-----DDEtLRKRLEKDMdtyfgLLKVKNLSDADVvrlcreensdgvvrvpdyvIA---F 371 Leishmania major
Q0JZP8         154 ---------------fQLRdlvvdgSRV-FEQMMRLAVqr---------------------------------dGD---G 181 Cupriavidus n...
Q7N8D4         145 ----------------DTFd-----KEK-LRSKLEFLW-----SIREKQINHVFNaq---------------asLD---F 179 Photorhabdus ...
WP_014360712   180 nfvmhadapdvavptlGLLr-----DRRaTIRALDALA-----AYARPLLAAAP--------------------ESattV 229 Gordonia poly...
Q090W1         160 ----------------DLLh-----PER-LLRKARQAQerlraELAEERRAASAHpqa-------------eaeLL---L 201 Stigmatella a...
A8F801         149 ----------------DFEt-----PAR-AESFLNEISrtwsiK------------------------------FD---V 173 Pseudothermot...
jgi:Theth_1863 148 ----------------DLQd-----EET-TRQRIQEIVsiwklD------------------------------VN---L 172
CDA58485       151 ----------------DFAsln----iqeLITRISHII-----KIDNVILNA----------------------FS---P 180
3R7T_A         183 EE---LL--------ADLKR-FNEIL--TP---YITDTTRXLWKALDEDKRVLLEGAQGSXL-DIDHGTYPYVTSSSTIS 244 Campylobacter...
Q386E7         266 ARaenKI--------DYLVKlYTERVknNKdfpRRCDVTHELRAALARGEKLLLEGPQSYWLsNAREKFWESTTSADTTA 337 Trypanosoma b...
Q4QG35         372 AQaedKV--------EFLVKlYRDRVrhNPgfpARCDVTYELHAALLRGEKVLLEGPQSYWLsNARTKFWESTTSADTTA 443 Leishmania major
Q0JZP8         182 EGlvaVV--------NAMRQ-AWKVV--EP---FVTDDPVALLRRVEAGANVLFEGAQSVML-DVVQGVQPWVTSSHTMP 246 Cupriavidus n...
Q7N8D4         180 EE---ML--------ETTHQ-YGKRI--EP---YFTFTNEIIGDLLNSGEDVLLETSQATFL-DNSFGTYPYTVAYQTLV 241 Photorhabdus ...
WP_014360712   230 DSvtdIA--------DTLCE-IADSIr------VVDDMPAYLSATIHAG-TTIFEGSQGALL-DEWHGFHPHTTWSTVVP 292 Gordonia poly...
Q090W1         202 MEdpgVS--------SRWVD-AVAAL--QPeqrVVEDA--WLGTRLQEG-TTVFEGAQGVLL-DENWGFHPHTTWSTCTF 266 Stigmatella a...
A8F801         174 KM---IL--------DSLIE-KYNKI--RD---LLIDSSEAVRVLK--EKDLLFEGTQGVLL-DVDMGTYPYVTSTNCST 233 Pseudothermot...
jgi:Theth_1863 173 NE---IV--------QDLYE-KYERI--KD---LIINTVEAIRTLA--GKSLLFEGTQGVLL-DVDAGTYPFVTSTNCSS 232
CDA58485       181 EN---TItkihtlidDSILS-YRSLI--VP---YIRDERPILNSALCNDDKIVVEGSQSFYL-DVDQGDYPYVTSSSPST 250
3R7T_A         245 AG--TLTGL-GLNPKEAGN-IIGIVKAY-ATRVGNGAFPTE--DK---------------------------------G- 283 Campylobacter...
Q386E7         338 GG--LLASA-QFNFQRYKVlVINVHKAPgSSRVGIGANPSS--FVpqdyysaqdiktlealpkggcvdfdkiqnffytKa 412 Trypanosoma b...
Q4QG35         444 AG--LLAAS-QLNFQKFKSvVLNVHKAPgSSRVGIGACPSS--FVpqdyfsaqniktlrdlpsatcahfeavqrtlfrDg 518 Leishmania major
Q0JZP8         247 SY--AYVGG-DLPCKY-HRkTIGVAKAI-VSRVGSGPLPTElgAGrseaycadaaregrggadeaarldplallaeadEf 321 Cupriavidus n...
Q7N8D4         242 q---TCFAMiGIPAQKM-H-IVGVMKSY-MIRVGNGPFPTE--LS---------------------------------T- 279 Photorhabdus ...
WP_014360712   293 GPlvQRLRStGHRPY-----VLGTTRCY-ATRHGYGPMPTE-------------------------------------S- 328 Gordonia poly...
Q090W1         267 DNalALLREhGFDGPV--H-RLGVLRAY-TPRHGEGPLPTE-------------------------------------N- 304 Stigmatella a...
A8F801         234 TG--IQPGF-G-YPVQVDK-IFGVMKAY-TTRVGEGPFPTE--LK---------------------------------D- 271 Pseudothermot...
jgi:Theth_1863 233 TG--IQSGF-G-YPVVVDE-IFGVFKAY-TTRVGEGPFPTE--LK---------------------------------G- 270
CDA58485       251 SG--TLAAA-GIGPVYV-RdVLGVAKAY-CSRAGEGPFNTE--QF---------------------------------G- 289
3R7T_A         284 --------------------ED----------GE-KIAQIGkEIGVSTGRKR---RCGWFDAVAVRYTARL-NGLDaLSL 328 Campylobacter...
Q386E7         413 fntesktfn--giyepleyeDAtgkynigvamSIaSARHHG-ECGAVTKKPR---VCGFFDCVLHFEVNAV-QGPY-LSI 484 Trypanosoma b...
Q4QG35         519 fphsndkarhngimapveysDEtgtynigvamAIaSAQHHG-ECGAVTKKPR---VCGFFDCVLHHEVNNI-QGPY-LTI 592 Leishmania major
Q0JZP8         322 --------------------SI----------GV-AIRMLSnEYGTGTGRPR---RVGLLDVAQLRLAVRQ-CGVDeVYL 366 Cupriavidus n...
Q7N8D4         280 --------------------EQ----------AD-YIRERGnEYGTVSKRPR---RCGWLDLSLIKHAVKL-NGVIeLAI 324 Photorhabdus ...
WP_014360712   329 --------------------------------GD-VV--LP-DVHNREGRYQgawRTGHLDLPALRYAAAVaGGLDgVAV 372 Gordonia poly...
Q090W1         305 --------------------------------AA-LAAALP-EPHNGAAGWQgrfRVGSFDAVLARYALAAcEGVDaLAV 350 Stigmatella a...
A8F801         272 --------------------EV----------GE-NLRRLGsEYGATTRRPR---RCGWLDLVLIKYAIET-SACNaLIM 316 Pseudothermot...
jgi:Theth_1863 271 --------------------EE----------GE-KLRKLGgEYGATTGRPR---RCGWLDLVLLKYAVEV-SGCKsLIL 315
CDA58485       290 --------------------ST----------AN-AIRKIGhEFNA-DGSPR---RVGWLDLVRLKNAVIQ-DGITeLCL 333
3R7T_A         329 XKLDVLD----GFEK-----IKICRAYEy----------------KGXEI-D-Y-IPs--------DL-EN--VQPIYEE 369 Campylobacter...
Q386E7         485 SAVDRGD----DYDR-----IGITIAYVyydvgnkmvdangrvykNGDIIkAgDpVPce------mAL-YH--CYPIVKV 546 Trypanosoma b...
Q4QG35         593 SALDRGD----EYDK-----VGVTIAYVyyspegkqvdvnghvykNGDIIrAgDpVPse------pAL-YH--CHPIVKL 654 Leishmania major
Q0JZP8         367 NKCDSLA----AFDRtrercIPVVAGATd---------------tGGQRVvR---FPa---------------------- 402 Cupriavidus n...
Q7N8D4         325 TNVDVLA----GLDE-----IKVAVAYEiddk---------lvccDNal----------------lQL-DR--AKPIYKT 367 Photorhabdus ...
WP_014360712   373 SHLDVL-----GTAG-----LRVADTW------------------DG--------DPtplsptragDLtALarLTEIAAR 416 Gordonia poly...
Q090W1         351 THLDRlq-----------arWPVCTAYRaplgcdgg--sfirdasDSRrvt---alRlgs----rgDLaYQerLTRGLFP 410 Stigmatella a...
A8F801         317 TKADILS----GFEK-----IPICMGYKi----------------GG-KFyT---QInn-----taHL-TE--IEPVYEE 359 Pseudothermot...
jgi:Theth_1863 316 TKSDVLC----GYGK-----IGVCVAYKv----------------AG-KIlE---AVdn-----lsCL-SK--AQPIYEY 358
CDA58485       334 MHMDDLGkigwKLGE-----IKVCTSY---------------------IYsQpHnWPitidyvpvdS--EN--CEPIYKS 383
3R7T_A         370 XDG-WD--KV-FGI--KDYDLLPENAKKYIARLEELAGVKVKYISTSPERDDTI 417 Campylobacter jejuni subsp. jejuni NCTC...
Q386E7         547 ING-WKgaPI-AASkrRPNEPLPKGVCEFIANVEFFTGAKVISIGNGPRGSDII 598 Trypanosoma brucei brucei TREU927
Q4QG35         655 IDG-WRdnPI-AAAkrRRNAPLPRGVCELLSAIEYFTNCKILSIGNGPNGDDII 706 Leishmania major
Q0JZP8         403 ----FAe-DT---IprDATSPLPPQLEALLEWLADAIGRPLRGIGLGPGRAQMR 448 Cupriavidus necator H16
Q7N8D4         368 FKS-WS--TLnSSY--TDLTELPIELIDFLSFIQDYTGVPIKYISYGPDRNQTL 416 Photorhabdus laumondii subsp. laumondii...
WP_014360712   417 ATP--------------DLRQLPADADGVAQLISQATGAPVVIRATGPARTDRS 456 Gordonia polyisoprenivorans
Q090W1         411 CEP-WP-----EVL--ELGENAEARAERFVSWLEATLEAPVKVTSHGPTSLDKH 456 Stigmatella aurantiaca DW4/3-1
A8F801         360 IKG-WK--SL-HSK----------EFDDFIYKIERELGLKFAYISTGPKIEEIT 399 Pseudothermotoga lettingae TMO
jgi:Theth_1863 359 LDG-WS--KL-SSK----------QFEKFIEKVEKATGARIVYISTGPRVDEMV 398
CDA58485       384 FKQgW---DT-SGC--TDYDSLPQPAKNFIEFIEEYLEIPVMYIGIGPDVHDII 431
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