Conserved Protein Domain Family
LEAP-2
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pfam07359: LEAP-2 
Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)
This family consists of several mammalian liver-expressed antimicrobial peptide 2 (LEAP-2) sequences. LEAP-2 is a cysteine-rich, and cationic protein. LEAP-2 contains a core structure with two disulfide bonds formed by cysteine residues in relative 1-3 and 2-4 positions. LEAP-2 is synthesized as a 77-residue precursor, which is predominantly expressed in the liver and highly conserved among mammals. The largest native LEAP-2 form of 40 amino acid residues is generated from the precursor at a putative cleavage site for a furin-like endoprotease. In contrast to smaller LEAP-2 variants, this peptide exhibits dose-dependent antimicrobial activity against selected microbial model organizms. The exact function of this family is unclear.
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Statistics
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PSSM-Id: 284718
Aligned: 3 rows
Threshold Bit Score: 130.823
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_021131249  38 MHCLKVMAIFLFCSLLLSQMHCASLHQPQPHLKRQRRMTPFWRGVSLRPIGASCRDNSECITMLCRKNRCFLRSASE 114
XP_003756533   1 MGHLKLLALFMVCLLLVSQVGSSPLPQQSSTQRRLKRMTPFWRGVSLRPIGASCHDDSECITRLCRKRRCSLNMTQE 77 
Q95JC3         1 MWHLKLFAVLMICLLLLAQVDGSPIPQQSSAKRRPRRMTPFWRAVSLRPIGASCRDDSECITRLCRKRRCSLSVAQE 77  cattle
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