Conserved Protein Domain Family
ARF7EP_C

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pfam14949: ARF7EP_C 
ARF7 effector protein C-terminus
This family represents the C-terminus of the ARF7 effector protein (ARF7EP). ARF7EP interacts with ADP-ribosylation factor-like protein 14 and unconventional myosin-Ie and through this interaction controls movement of MHC-II-containing vesicles along the actin cytoskeleton in dendritic cells. It contains a conserved CXCXXXXCXXCXXXCXXCXXXXCXXXCXC motif in it's C-terminal half.
Statistics
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PSSM-Id: 464395
Aligned: 29 rows
Threshold Bit Score: 98.1167
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAP28782      68 QRELEGLQFQNPGGKI-----AKPDTsdiyNtNRARRNHVNLSK----QqQMQEVKekaLHHDANGKLS---STVRget- 134
1_pfamImport   1 KRELRGLTFVNPGGEMs---kMLPDSadivStSRSRRAHQQQAV------EPKEPKdavLHHDKLGRLT---SIVKgsa- 67 
Q17483        69 HRELQGLQFANPGDEMs---rFLPDSvdiiStNRSKRVAAEKQA---------DLRdepLHHDKTGKLS---VTAKgqt- 132 Caenorhabditis ...
XP_003110938  66 QRELQSLQFDNPGGEMv---rFLPDSadivNaNRSRRNYTEKQA---------EIReeaIHHDKTGKLS---TTTKgqt- 129
PDM70830      95 QRVTRSLLFANPGVNAk---ePAYYI----DlHREKRAAANIANa---KiVRNPQTs-sYAHNEKGEFI---VRTMindk 160
EJW85076      38 HRELRNLRFINPGEAa----lISTEE----T-LYDRHGIRRSARhrkaLtSVDRMTdyiPHHDEEGYLIrvdGHCV---- 104
XP_014341634  33 ERQLKCLAFQNPGPQLa---eFNPET----R-LQKKKARMSEVNd-----FFTVNKalkKKYDKMGKLL---CNGV---- 92 
AAI11163      36 DRQLKRLSFQNPGPQVa---nFNPEI----R-QQIKKGQMAKKNe-----FVSVKRe-gNKYDKKGRLT---FNEA---- 94 
XP_016279242  39 ERQLKSLAFQNPGPQVa---dFNPET----R-EQKKKAHMSKMNe-----YFSVNKv-mKKYDRNGRLI---CNDV---- 97 
XP_002052617   3 ARSLRQRP-QRPKETIddnssTEAEK----TkRRGKKK-------------GCYYGk-sSAYDEYGNIR---SNGL---- 56 
CAP28782     135 ----sviDLCDCLDAKCDGCQWPCKTCSSRKCLIGCRTNRREMAAKCEEM 180
1_pfamImport  68 ----tvhDPCDCLREKCNGCNWPCRTCKSRKCLVGCRQNRKEMVVKIE-D 112
Q17483       133 ----lffDLCDCLVVECDGCHWPCKQCKSRKCLIGCRQNRKEMVIRVEEM 178 Caenorhabditis elegans
XP_003110938 130 ----eviDLCDCLNPDCDGCHWPCATCKSRKCVFQCRQGRRDMIARVEEM 175
PDM70830     161 eveigkiPLCDCCKVECKGCFWPCAKCGGRRCSTECQVLRPY---AIAST 207
EJW85076     105 -------KLCDCLRMSCPGCHYPCEKCGSRMCGPACQRNRDYIIESFFAE 147
XP_014341634  93 -------DLCDCLEEDCRGCFYPCPRCNSTKCGVECRRNRKWVYDRIEVE 135
AAI11163      95 -------DLCDCLDEDCLGCFYPCPKCKSTKCGPICRCNRRWAYDTIVNE 137
XP_016279242  98 -------DLCDCLEKNCLGCFYPCPKCNSNKCGPECRCNRKWVYDDIVTE 140
XP_002052617  57 -------DVCDCMNEECDGCWYECRSCGSTRCGPQCRVNRKFFYENIVYD 99 
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