Conserved Protein Domain Family
zf-3CxxC

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pfam13695: zf-3CxxC 
Zinc-binding domain
This is a family with several pairs of CxxC motifs possibly representing a multiple zinc-binding region. Only one pair of cysteines is associated with a highly conserved histidine residue.
Statistics
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PSSM-Id: 463958
Aligned: 128 rows
Threshold Bit Score: 31.2367
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CDS41392     278 EAKTRFMCSKCSKQWTSMKGAITFVVImshQTTPtmevvapqaamegatwssqgcvtlrpganVLLELFPQACAECalhg 357
Q38DX3        24 RRPGIFRCRVCSNTWTSSHVWVTr--------------------------------------tTQRVYQGESCEEC---- 61  Trypanosoma brucei
CBZ13068      24 KRTGKFRCKVCQHSWFSDEVWVTk--------------------------------------tTQRVYQGESCETC---- 61 
CAM43652      24 KRTGKFRCKVCQRCWFSDEVWVTk--------------------------------------tTQRVYQGESCEAC---- 61 
Q4D441        24 RRRGFFRCRVCQNSWGSSNVWVTk--------------------------------------tTQRVYQGESCEKC---- 61  Trypanosoma cruzi
XP_002607077 275 QKYGYFHCHNCDWRWESAYVWCVs--------------------------------------gTDKVYFKQDCRLC---- 312
XP_007247360 227 QKYGFYHCNKCNIRWESAYVWCIt--------------------------------------gSSKVYFKQHCRKC---- 264
ELW71628     565 QKYGYYHCKDCNIRWESAYVWCVq--------------------------------------gTNKVYFKQFCRTC---- 602
EXX58094     265 RVFGNWGCSSCRKRWRSAYTWISLQKYiekTPGKrl-------------------------nrFNDDYIIQKCKK----- 314
EXX77279     287 RVYGDWNCCGCDVSWPSAFTWISLQKFmdeIPGEs---------------------------lNRGDFYTQKCKKCenpe 339
CDS41392     358 eVRLSPPKWYpEEVDKVLRNLFVNIHRTFYKNvifweqqfdrrRRpGHPtg----------------------------- 408
Q38DX3        62 -------------------------------------------GTtTKPyyigrpeet---------------------- 76  Trypanosoma brucei
CBZ13068      62 -------------------------------------------GTtNKPyyvgrpeet---------------------- 76 
CAM43652      62 -------------------------------------------GTtNKPyyvgrpeet---------------------- 76 
Q4D441        62 -------------------------------------------GTtTKPyyvgrsaet---------------------- 76  Trypanosoma cruzi
XP_002607077 313 -------------------------------------------QNaINPyfveglycgrcrespckcpqrpradmsmqyn 349
XP_007247360 265 -----QAGLNpYRVESIQCQTCEQSRCSCEQK-----------QRhIDLrr----------------------------- 299
ELW71628     603 -------------------------------------------QKsYNPyrveditcqrckqtr----------cscpvr 629
EXX58094         --------------------------------------------------------------------------------    
EXX77279     340 nKILEYAPLKkAEg--------------------------------KKP------------------------------- 356
CDS41392     409 --------rHD-NTKCLACLNG 421
Q38DX3        77 -ifnrtrtpHPvKPGASTSRHG 97  Trypanosoma brucei
CBZ13068      77 -ifnrartpHPvKRGVSSSRSE 97 
CAM43652      77 -ifnschtpHPvKRGVSSSRSE 97 
Q4D441        77 -vfnrvktpHPvKAEASSSRHG 97  Trypanosoma cruzi
XP_002607077 350 pgelnsrklHR-RELCHRCRDK 370
XP_007247360 300 --------pHR-QDLCGRCRGK 312
ELW71628     630 lrhvdpkrpHR-QDLCGRCKGK 650
EXX58094     315 ----------------EECGDD 320
EXX77279     357 ---------HT-RGVCIKCLYY 368
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