Conserved Protein Domain Family
LSm11_M
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cd01739: LSm11_M 
Like-Sm protein 11, middle domain
The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet. LSm11 is an SmD2-like subunit which binds U7 snRNA along with LSm10 and five other Sm subunits to form a 7-membered ring structure. LSm11 and the U7 snRNP of which it is a part are thought to play an important role in histone mRNA 3' processing.
Links
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Statistics
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PSSM-Id: 212485
Aligned: 17 rows
Threshold Bit Score: 81.9214
Created: 24-Sep-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative RNASm1 motifSm2 motif
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Residues within loops 3 and 5 of the SM1 motif bind RNA
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                        # #                      #        
P83369       159 LHRCIREGVKVNVHIRTFKGLRGVCTGFLVAFDKFWNMALTDVDETYrkpvlgKAYERDSSLTLTR 224 human
AAQ08119     129 LNRCVQDRIRIRVHIRTFKGLRGVCSGFIVAFDKFWNMAMVDVDETYrkpvlgKAFYNEPQLTLTR 194 African clawed frog
AAH93279     167 LNRCVQEKIRVKVHIRTFKGLRGVCSGFVVAFDKFWNLAMVDVDETYrepllgQALYHEKALTITR 232 zebrafish
XP_001844458 135 MRTWMRERVRVKVYTRKEKGVRGFVTGFIEVFDKHWNLALSDVFESWrr---rKYRYSENKRAGLG 197 southern house mosquito
EFX89722     117 LRNCMINKTRVKVWIRGATWIRGFCIGYIAAFDKQWNLAMTDVDETFtrrrhrKTPILGPVDHITE 182 common water flea
XP_002129131  74 LHRITNDRARCKVFTRNFCGLRGVLCGYVVAYDRFMNMVMVDVDETFcksplgGVAQHQQRMSTFK 139 Ciona intestinalis
XP_001687956 128 LQRWMEGRNRVRVSIRKQKGVRGHVSGVLELFDKHWNLALSDVCETWtr---rKYRYSENRQHPDS 190 Anopheles gambiae str. PEST
XP_001943900 112 IALFCYAKKRVKVYIRSAVSVRGHCEGYIIAFDKHWNLVMDDVDEVWt----rKNKYKSLAIGDAR 173 pea aphid
EGB12655     159 LWRALRDRAAVKVVLRRVNCIRGSCVGLLKAFDRHMNLVLVDAAETTv----pPMRNPDRARPVTR 220 Aureococcus anophagefferens
EFN53897     113 LKRWYQQRSRVRVVTRHARGVRGSSEGLLVAFDKHMNLVLRDVEEQYt----vLLQVQRVKPPAPG 174 Chlorella variabilis

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