1QQK,1QQL


Conserved Protein Domain Family
beta-trefoil_FGF7

?
cd23319: beta-trefoil_FGF7 
FGF domain, beta-trefoil fold, found in fibroblast growth factor 7 (FGF7) and similar proteins
FGF7, also called heparin-binding growth factor 7 (HBGF7), or keratinocyte growth factor (KGF), plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. It is required for normal branching morphogenesis. It is a growth factor active on keratinocytes. It may act as major paracrine effector of normal epithelial cell proliferation. FGF7 interacts with fibroblast growth factor receptor FGFR2 and fibroblast growth factor-binding protein 1 (FGFBP1). Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. FGF7 contains a FGF domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.
Statistics
?
PSSM-Id: 467005
Aligned: 7 rows
Threshold Bit Score: 253.634
Created: 6-Apr-2021
Updated: 27-Apr-2023
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1QQK_A         3 DYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEmRNSYNIMEIRTVAvGIVAIKGVESEYYLAMNKEGKLYAKKECNED 82  Norway rat
1QQL_A         3 DYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEmRNSYNIMEIRTVAvGIVAIKGVESEYYLAMNKEGKLYAKQTPNEE 82  Norway rat
P21781        57 DYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEmKNNYNIMEIRTVAvGIVAIKGVESEFYLAMNKEGKLYAKKECNED 136 human
NP_001012543  57 DYMEGGDVRVRRLFCRTQWYMRIDKRGKVKGTREaNNNYSILEIRTVAvGIVAIKGVESEYFLAMNKSGRLYGKKVCNED 136 chicken
NP_001089637  57 DYMEGGDVRIRKLFCRTQWYLCIDKRGNVKGTQDpNNSFSILEIRTVAvGIVAIKCIESEYFLAMNKSGRLYGKKSCNEE 136 African clawed ...
XP_005998372  57 DYMEGGDVRVRKLFCRTQWYLMIDRRGKVKGTRDpNNSFSILEIRTVAvGIVAIKGVESEYFLAMDESGKVYGKKVCNED 136 coelacanth
XP_007904463  24 DYMEGGDVRIRKLFCRTQFYLRIDKKGKVKGTANsNCNYCILEIRTVAvGVVAIRGVESDYFLAMNKAGKLYGKKNCNED 103 elephant shark
1QQK_A        83 CNFKELILENHYNTYASAKWTHsGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMA 138 Norway rat
1QQL_A        83 CLFLERLEENHYNTYISKKHAEkNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVS 138 Norway rat
P21781       137 CNFKELILENHYNTYASAKWTHnGGEMFVALNQKGIPVRGKKTKKEQKTAHFLPMA 192 human
NP_001012543 137 CNFIELIEENHYNTYASAKWTHkGKEMFVTLNHKGVPMKGKKTKKEHRASHFLPLA 192 chicken
NP_001089637 137 CNFRELIQENKYNTYASAKWTNnGKEMFVALNSKGSPMKGKKSKKEHKGSHFLPTS 192 African clawed frog
XP_005998372 137 CNFKELIQENHYNTYTSAKWTHkGKEMFVALSIKGNPKKGSKTKKERKPTHFLPLA 192 coelacanth
XP_007904463 104 CNFKELIEENNYNTYASAKWTHhGQPMFIALNPKGKTIQGRKTKKENKSSHFLPMA 159 elephant shark
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap