1Z9T,1RV9,1XFJ,6DZD


Conserved Protein Domain Family
Cu-oxidase_4

?
pfam02578: Cu-oxidase_4 
Multi-copper polyphenol oxidoreductase laccase
Laccases are multi-copper oxidoreductases able to oxidize a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms.
Statistics
?
PSSM-Id: 460601
Aligned: 580 rows
Threshold Bit Score: 159.959
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1Z9T_A              32 STRIGGVSLPPYDSLNLGAHCGDNPDHVEENRKRLFAAG--NlpskPV-WLEQVHGKDV---LkLTGE--PYASKR---- 99  Escherich...
WP_012959474        30 TTRKGGLSEPPFNTLNMGFHVNDESDTVLKNRERFAEIIsfPl--sQWvGSEQVHGSTIqkvTkEDMGlgARTIQDaisa 107 Alkalihal...
Q5WFH7              19 TTRHGGVSKRPYATLNMGFHVGDDQNDVQRNRSLVAADIgfPl--tKWiGSEQVHQAEIaevTaADAGrgADCLETalpg 96  Bacillus ...
Q9K9U4              29 TTRLDGVSSPPYDSLNLGLHVGDDEQAVIQNRELLAAELqvPl--sQWvFAEQIHGSEVvhvTaHDRGagAFERQSalkg 106 Bacillus ...
WP_013372078        44 TGRHGGVSEAPYDSLNCAFHVGDDPEKVIRNRRLIAEQLgfAa--eAWtCGEQVHGNHVavvQaADRGrgFMDRASafqd 121 Paenibaci...
WP_015734242        33 TGRHGGVSRIPYDSLNLAFHVGDEPGDIVENRKRVAAALgfSl--eDWtCGEQVHGIRIgvvHdKDRGrgSLDRASayqd 110 Paenibaci...
sklacau:PSAB_17345  31 TGRAGGAGRTPYDSLNCAFHVGDIPEDVIKNRKLVAESLgfSl--eDWtCGEQVHGSEIavvTaDDKGrgSLERSTafad 108
WP_015845449        33 TGRNGGVSEQPWTSLNVGLHVGDSDDDVVRNRQLIAETIgwPf--eAWtCGEQVHGCEVfqvTeSERGkgRLSRDSaiad 110 Paenibaci...
WP_015255161        32 TGREGGVSSPPWASLNCGLHVGDTAEAVVRNRALAAEAAgwDp--aAWtCAEQVHGCRVhrvAsADRGrgGKDLESaipg 109 Thermobac...
WP_015892084        31 TIRSGGESEQPYGSFNMGLHVGDESANVVANRRKLAEQVgmSf--sAWtCADQVHGNQVcqvT-A-GGagKESLEDviss 106 Brevibaci...
1Z9T_A             100 ADASYSNTPGTVCAVXTADCLPVLFCNRAGT--EVAAAHAGWRGLCAGVLEETVSCFa----dNPENILAWLGPAIGPRA 173 Escherich...
WP_012959474       108 ADGLYTKERGILLTSLYADCVPLLFFAKNHG--IIGVAHAGWKGTVQLIGPKMIEKWnndegvPLNDIQVAIAPCISKEA 185 Alkalihal...
Q5WFH7              97 LDGIYTQEQGLLLTSLYADCVPLYFAAKSAG--LIGLCHAGWKGSVAKIGPKLLGIWkekhcvSASDVHVLIGPSICASR 174 Bacillus ...
Q9K9U4             107 ADGLYTSDQGILLCSLYADCVPLYFYAEHRGaiYIGLAHAGWKGTVGQIGAKLVHAWterfylPKEAIHAAIGPSISCEA 186 Bacillus ...
WP_013372078       122 TDGLLTNIPGILLTSFYADCVPLYFCDPVHR--VIGLAHAGWKGTVAEIALKMVQTMqteygsQPSDILAAIGPSIGPES 199 Paenibaci...
WP_015734242       111 TDGLVTDVPGVLLTSFYADCVPLYFWDPVTG--AVGLAHAGWKGTVGGIAEQMVVRMsaeygsLPRNLHAAIGPSIGECC 188 Paenibaci...
sklacau:PSAB_17345 109 TDGLLTDVPGVLLASFYADCVPLYFHDPVTG--AVGLAHAGWKGTVAEIALSMAGRMeavygsRKEDIRAAIGPSIGACC 186
WP_015845449       111 TDGLMTDIPGVLLASFYADCVPLYFYDQQHQ--AVALAHAGWKGTVQQIASKTIEAMerqygtKPEELLCAIGPSISDCC 188 Paenibaci...
WP_015255161       110 ADAIMTDEPGILLASYYADCVPLLFHDPKRG--AVALAHAGWRGTTLEIAARTIEAMerefgsRPADIRAAIGPAIGPCC 187 Thermobac...
WP_015892084       107 TDGLFTLEKGVMLTSFYADCVPLYFLHPQSG--AIGLAHAGWKGTVGRIAEEMVKAMtkhyqaKPADIFVAIGPSIGGCC 184 Brevibaci...
1Z9T_A             174 FEVGGEVREAF-------------------------XavdakasaafiqhgdKylADIYQLARQRLANVGV--EQIFGGD 226 Escherich...
WP_012959474       186 YEVDDFVINKVinalpyaee-------kvvytkkvnG---------------KyqLDLRLLNKHLLIEAGIeeRNIYVSS 243 Alkalihal...
Q5WFH7             175 YEVDEVVASKVkdalggeaa--------gvltptkpG---------------HslLDLPMLNKQLLVAAGVnpSHIHTSN 231 Bacillus ...
Q9K9U4             187 YEVDQVVIDQIdralsseat--------rpyvkreeG---------------RyqLDLKACNEQLLIDAGLekAQILVSS 243 Bacillus ...
WP_013372078       200 YEVDEHVMSQIrvlehdcpgndk--wegsvyfpltgG---------------KtlLDLKQCNRHIMMKAGIlpSHIECTT 262 Paenibaci...
WP_015734242       189 YEVDDRVMERVrelgiegfsgdk-vtnsafyidkghG---------------KymLNLKEINRHIMIKAGIlaEHIECTS 252 Paenibaci...
sklacau:PSAB_17345 187 YEVDDFVMDHVrrleeslirdeesgeslyspstahiG---------------KmmLNLKELNRRIMIKAGIlpTHIECTS 251
WP_015845449       189 YEVDGFVIDKLqplvegladkln-sssdlmmtlvenG---------------KamVNLKQINRHIMLEAGIlpIHIELSE 252 Paenibaci...
WP_015255161       188 YEVDGPVIGSAlplaeslapsgg-apldamirmtddG---------------KarLNLKEMNRQIMIRSGImpSRIAFSS 251 Thermobac...
WP_015892084       185 YEVDERIMTQVrtcagdwe---------kavisstgD---------------RymLDLRQLNTAILLEVGIssGNIFSTN 240 Brevibaci...
1Z9T_A             227 RCTYTENETFFSYRRdK----TTGRXASFIW 253 Escherichia coli
WP_012959474       244 ICTA-EDDRLYSYRAeSg---KTGRFMSYIG 270 Alkalihalobacillus pseudofirmus
Q5WFH7             232 VCTY-ESDAFFSHRKeKg---RTGRMMSAIG 258 Bacillus clausii KSM-K16
Q9K9U4             244 HCSA-QSNLLFSHRHeGg---KTGRMMSFIG 270 Bacillus halodurans
WP_013372078       263 LCTSSRSDLFFSYRKeGg---VTGRMASWIG 290 Paenibacillus
WP_015734242       253 WCTSCNHDRFFSYRKdGg---TTGRMASWIG 280 Paenibacillus sp. Y412MC10
sklacau:PSAB_17345 252 WCTSCSPDLFFSYRKeNg---VTGRMASWIG 279
WP_015845449       253 WCTGCSTDQFFSHRKeGg---KTGRMASWIG 280 Paenibacillus sp. JDR-2
WP_015255161       252 FCTGCRRDLFFSHRReGg---RTGRMASFIG 279 Thermobacillus composti
WP_015892084       241 WCTSCRTDLFFSHRKeAgiqgTTGRMASYIG 271 Brevibacillus brevis
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap