1T47,1CJX,3ZGJ,2R5V


Conserved Protein Domain Family
4HPPD
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TIGR01263: 4HPPD 
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4-hydroxyphenylpyruvate dioxygenase
This protein oxidizes 4-hydroxyphenylpyruvate, a tyrosine and phenylalanine catabolite, to homogentisate. Homogentisate can undergo a further non-enzymatic oxidation and polymerization into brown pigments that protect some bacterial species from light. A similar process occurs spontaneously in blood and is hemolytic (see . In some bacterial species, this enzyme has been studied as a hemolysin. [Energy metabolism, Amino acids and amines]
Links
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Statistics
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PSSM-Id: 273528
Aligned: 20 rows
Threshold Bit Score: 422.459
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1T47_A              21 KGMDAVVFAVGNAKQAAHYYSTAFGMQLVAYsgpE---NGSRETASYVLTNGS-ARFVLTSVIKPAtp-----------w 85  Streptomy...
O23920              44 KRFHHIEFWCGDATNTSRRFSWGLGMPLVAKsdlS---TGNSVHASYLVRSAN-LSFVFTAPYSPStttssgsaaipsfs 119 carrot
FlyBase:CG11796-PA  17 LSFDHLTFYVGNAKQAASYYTTRLGFEPLGYqglE---TGERRFAKHAVRQNK-IVFVFVSAYTPDd------------- 79  fruit fly
Q27203              27 LGYDHLHFWVGNAKQAAGWYTSRFGFEYYAYkglE---TGSREVATHVVRNKQgVTLAFSTPYGNDkd-----------n 92  Tetrahyme...
Q18347               5 SAIHHIEFIVSNALQSAYWYCSGFGFEKFA----E---KITDESTSIALRNGT-ARVIITSYNSQN-------------- 62  Caenorhab...
CAB38519            17 SDIAYAELYVADDREASGFLVDSLGFVPLAVagpA---TGTHDRRSTVLRSGE-VTLVVTQALAPD-------------- 78  Streptomy...
CAA11761             4 FEIDYVEMYVENLEVAAFSWVDKYAFAVAG----T---SRSADHRSIALRQGQ-VTLVLTEPTSDR-------------- 61  Amycolato...
WP_000810913        20 RDVDHLEFYVGNAKQSSYYLARAFGFKIVAYsglE---TGNREKVSYVLVQKN-MRFVVSGALSSD-------------- 81  Bacillus
Q00415              22 RGYDHVHWYVGNAKQAATYYVTRMGFERVAYrglE---TGSKAVASHVVRNGN-ITFILTSPLRSVeqasrfp--edeal 95  Coccidioi...
3ZGJ_A              17 SDIAYAELYVADDREASGFLVDSLGFVPLAV---AgpaTGTHDRRSTVLRSGE-VTLVVTQALAPD-------------- 78  Streptomy...

1T47_A              86 gHFLADHVAEHGDGVVDLAIEVPDARAAHAYAIEHGARSVAEPYElkdEh---gTVVLAAIATYG-KTRHTLVDRT-G-Y 159 Streptomy...
O23920             120 aSGFHSFAAKHGLAVRAIALEVADVAAAFEASVARGARPASAPVEl-dD-----QAWLAEVELYG-DVVLRFVSFG-R-E 190 carrot
FlyBase:CG11796-PA  80 -EEHGLHLMRHGDGVKDVAFEVEDLNAIFTLAVSRGAEVVRDIWEe-sDdq--gFVRFATIKTYG-DTTHTFVERN-G-Y 152 fruit fly
Q27203              93 qREMNQHQSLHGDGVKDVAFAVEDCHSIYNKAIQRGAKCAYPPQDl-kDeh--gSVTIAAVHTYG-EVIHTFIQRN-D-Y 166 Tetrahyme...
Q18347              63 --IYTDQLIKHGDFIKDVSFRVDNLDAVLQNLVENDIKVIQQSEVs-tKd---gLVRTATLLSEGgDVTHTLFELG-E-F 134 Caenorhab...
CAB38519            79 -TPVARYVERHGDSIADLAFGCDDVRSCFDRAVLAGAEALQAPTPs--Hra-gqDAWFATVSGFG-DIRHTLVPAA-DgD 152 Streptomy...
CAA11761            62 -HPAAAYLQTHGDGVADIAMATSDVAAAYEAAVRAGAEAVRAPG----Qhs-eaAVTTATIGGFG-DVVHTLIQR--DgT 132 Amycolato...
WP_000810913        82 -NRIAEFVKTHGDGVKDVALLVDDVDKAYSEAVKRGAVAIAPPVEltdEn---gTLKKAVIGTYG-DTIHTLVERK-N-Y 154 Bacillus
Q00415              96 lKEIHAHLERHGDGVKDVAFEVDCVESVFSAAVRNGAEVVSDVRTv-eDed--gQIKMATIRTYG-ETTHTLIERS-G-Y 169 Coccidioi...
3ZGJ_A              79 -TPVARYVERHGDSIADLAFGCDDVRSCFDRAVLAGAEALQAPTP---ShragqDAWFATVSGFG-DIRHTLVPAAdG-D 152 Streptomy...

1T47_A             160 DGPYLPGYVA---AAPIVEppAHRTFQAIDHCVGNVElgRMNEWVGFYNKVMGFTNMKEFvgdD---IATEYSALMSKVV 233 Streptomy...
O23920             191 EGLFLPGFEAvegTASFPD--LDYGIRRLDHAVGNVT--ELGPVVEYIKGFTGFHEFAEF---TaedVGTLESGLNSVVL 263 carrot
FlyBase:CG11796-PA 153 AGDFLPGFQRsp-kDVLLNglPSTKLNFIDHVVGNQPdlQMESVASWYERILQFHRFWSV---DdsqIHTEYSALRSIVM 228 fruit fly
Q27203             167 KGFFMPGFVAhplKDPLNNvlPDISYNYVDHIVGNQPdnMMTSAADWYEKTLDFHRFWSV---DdsmIHTEFSSLRSIVM 243 Tetrahyme...
Q18347             135 KGNFLPFFTPis-nFELFEniEKMPAILMDHVVQNYPigEMEAAADWYFKTMRLKRFWSV---DdkvATSEFSAMTAWLL 210 Caenorhab...
CAB38519           153 GAGLLPPDRDwalLPAATGr-TGPRPL-LDHVAVCLEsgTLRSTAEFYEAAFDMPYYSSE---Y---IEVGEQAMDSIVV 224 Streptomy...
CAA11761           133 SAELPPGFTgs-mDVTNHGk-GDVDLLGIDHFAICLNagDLGPTVEYYERALGFRQIFDE---H---IVVGAQAMNSTVV 204 Amycolato...
WP_000810913       155 KGTFMPGFQ----KAEFDIpfEESGLIAVDHVVGNVEk--MEEWVSYYENVMGFKQMIHF---DdddISTEYSALMSKVM 225 Bacillus
Q00415             170 RGGFMPGYRMesnADATSKflPKVVLERIDHCVGNQDwdEMERVCDYYEKILGFHRFWSV---DdkdICTEFSALKSIVM 246 Coccidioi...
3ZGJ_A             153 GAGLLPPDRDwalLPAATGrtGPRPL--LDHVAVCLEsgTLRSTAEFYEAAFDMPYYSSE---Y---IEVGEQAMDMIFV 224 Streptomy...

1T47_A             234 ADGTLKVKFPINEPALA-KKKSQIDEYLEFYGGAGVQHIALNTGDIVETVRTMRAA----GVQFLD-TPDSYYDTLGEWV 307 Streptomy...
O23920             264 ANNEEMVLLPLNEPVYGtKRKSQIQTYLEHNEGAGVQHLALVSEDIFRTLREMRKRsclgGFEFMPsPPPTYYKNLKNRV 343 carrot
FlyBase:CG11796-PA 229 ANYEETVKMPINEPANG-KKKSQIQEYVEYYGGGGVQHIALNTDDIIEAVSNLKAR----GTEFLT-IPSSYYEILQEQL 302 fruit fly
Q27203             244 TDYDQKIKMPINEPADG-KRKSQIQEYIDFYAGPGVQHIALNTSDVINTVEGLRAR----GVEFLS-IPTSYYDNLRKAL 317 Tetrahyme...
Q18347             211 VNDDHTVQVTLAEGVKGrKGKSQIEEFINYHGGSGVQHFALLVEDIISAVQIMKSR----SVEFLT-IPSQYYDNLEERL 285 Caenorhab...
CAB38519           225 RNAGGGITFTLIEPDDT-RVPGQIDQFLSAHDGPGVQHLAFLVDDIVGSVRSLGDR----GVAFLR-TPGAYYDLLTERV 298 Streptomy...
CAA11761           205 QSASGAVTLTLIEPDRN-ADPGQIDEFLKDHQGAGVQHIAFNSNDAVRAVKALSER----GVEFLK-TPGAYYDLLGERI 278 Amycolato...
WP_000810913       226 TNGS-RIKFPINEPADG-KRKSQIQEYLEFYNGAGVQHLALLTNDIVKTVEALRAN----GVEFLD-TPDTYYDELTARV 298 Bacillus
Q00415             247 ASPNDIVKMPINEPAKG-KKQSQIEEYVDFYNGAGVQHIALRTNNIIDAITNLKAR----GTEFIK-VPETYYEDMKIRL 320 Coccidioi...
3ZGJ_A             225 RNAGGGITFTLIEPDDT-RVPGQIDQFLSAHDGPGVQHLAFLVDDIVGSVRSLGDR----GVAFLR-TPGAYYDLLTERV 298 Streptomy...

1T47_A             308 GD----T-RVPVDTLRELKILADRDEDGYLLQIFTKPVQDRPTVFFEIIERH---------------GSMGFGKGNFKAL 367 Streptomy...
O23920             344 GDv---LsDEQIKECEDLGILVDRDDQGTLLQIFTKPVGDRPTLFIEIIQRVgcmlkddagqmyqkgGCGGFGKGNFSEL 420 carrot
FlyBase:CG11796-PA 303 SHsr-tKiKEDMEVLKKLNILIDFDENGYLLQIFTKNCQDRPTLFLEVIQRY---------------NHNGFGAGNFKSL 366 fruit fly
Q27203             318 TAqtsiTvKEDLDVLQKNHILVDYDEKGYLLQIFTKPVEDRPTLFYEIIQRN---------------NHQGFGAGNFKSL 382 Tetrahyme...
Q18347             286 SKtn-lIvKEDLKMIRELNILMDFDENGYLLQIFSKPLQDRPTLFIEIIQRA---------------NFKGFGAGNFKAL 349 Caenorhab...
CAB38519           299 G-----AmADAIEDLRETNVLADRDEWGYLLQIFTRSPYPRGTLFYEYIQRN---------------GARGFGSSNIKAL 358 Streptomy...
CAA11761           279 T-----LqTHSLDDLRATNVLADEDHGGQLFQIFTASTHPRHTIFFEVIERQ---------------GAGTFGSSNIKAL 338 Amycolato...
WP_000810913       299 G-----KiDEEIDKLKELKILVDRDDEGYLLQIFTKPIVDRPTLFIEIIQRK---------------GSRGFGEGNFKAL 358 Bacillus
Q00415             321 KRqg-lVlDEDFETLKSLDILIDFDENGYLLQLFTKHLMDRPTVFIEIIQRN---------------NFSGFGAGNFRAL 384 Coccidioi...
3ZGJ_A             299 G-----AmADAIEDLRETNVLADRDEWGYLLQIFTRSPYPRGTLFYEYIQRN---------------GARGFGSSNIKAL 358 Streptomy...

1T47_A             368 FEAIEREQEKRGNL 381 Streptomyces avermitilis
O23920             421 FKSIEEYEKTLEAK 434 carrot
FlyBase:CG11796-PA 367 FTAIEIEQAKRGNL 380 fruit fly
Q27203             383 FVSLELEQEKRGNL 396 Tetrahymena thermophila
Q18347             350 FDAVEREQEKRGTL 363 Caenorhabditis elegans
CAB38519           359 YEAVEREREVAGR- 371 Streptomyces coelicolor A3(2)
CAA11761           339 YEAVELERTGQSEF 352 Amycolatopsis orientalis
WP_000810913       359 FESIEREQERRGNL 372 Bacillus
Q00415             385 FEAIEREQALRGTL 398 Coccidioides posadasii C735 delta SOWgp
3ZGJ_A             359 AEAVEREREVAGR- 371 Streptomyces coelicolor A3(2)
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