Conserved Protein Domain Family
beta-trefoil_IL1

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cl00094: beta-trefoil_IL1 Superfamily 
beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines
The IL-1 family of cytokines comprises 11 members, including 7 pro-inflammatory agonists (IL-1alpha, IL-1beta, IL-18, IL-33, IL-36alpha, IL-36beta, IL-36gamma) and 4 defined or putative antagonists (IL-1R antagonist (IL-1Ra), IL-36Ra, IL-37, and IL-38) exerting anti-inflammatory activities. These members can have complimentary or distinct biological functions. All family members share a common structure at the C-terminus, which is comprised by of a typical beta-trefoil fold consisting of 12-beta-strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.
Links
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Taxonomy: root
PubMed: 102 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl00094
PSSM Id: 469612
Name: beta-trefoil_IL1
Created: 8-Feb-2008
Updated: 4-Oct-2023
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