3LXW,2XTM,3LXX


Conserved Protein Domain Family
AIG1

?
cd01852: AIG1 
Click on image for an interactive view with Cn3D
AvrRpt2-Induced Gene 1 (AIG1)
This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).
Statistics
?
PSSM-Id: 206651
Aligned: 50 rows
Threshold Bit Score: 222.411
Created: 12-Dec-2003
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Structure:3LXW: Human Gtpase Imap Family Member 1 binds GDP; contacts at 4.0A
  • Citation:PMID 9242920

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1              ######            #                                                    
3LXW_A     22 RRLILVGRTGAGKSATGNSILGQRRFFSrlg-atsVTRACTTGSRRw--------dKCHVEVVDTPDIfssqvsktdpGC 92  human
CAF95106  314 LRLVLLGRSGSGKSTAGNIILGQEVFRTlpdsltaVTQDSEKKKKVv--------eGRRVAVVDTADWfnsek-tpeeVR 384 Tetraodon nigrovir...
CAF95106   17 VRLILVGNIGCGKTTSADTILGQPSHVSg-----gRSRSCQRRNGTf--------dHRSLVLVEAPRWywsggkmeesVR 83  Tetraodon nigrovir...
CAF93509   12 IRLVLLGKTGSGKSSTANTILGRKVFDTkvs-gstVTQHCRRANGEi--------cGRTLILLDTPGLldtsq-mpleLQ 81  Tetraodon nigrovir...
CAF95840   13 LRLVMVGKTGTGKSASGNTILGHRCFESkfs-aksLTVDCHRERGEv--------gGQRVAIIDSPGLfdtrf-smerTS 82  Tetraodon nigrovir...
CAG01646  137 SHLALPLGTLAPPPLEQVGRAGREEMGAhlqgassVTEVCQVGTAEptededgqrrTRRVTVIDTPGYgntsl-deeqTR 215 Tetraodon nigrovir...
AAH83287    7 INIVLLGKTGVGKSSSGNTILGENRFRCgrr-lsaVTDTSSIEKSVt--------nGRSVSVIDTPGFfstnl-pkeqLA 76  zebrafish
AAH91547   66 LRLVLLGKTGAGKSATGNTILGEKRFNDdls-mssVTKECQRENTSt--------eGRNLLLVDTPGFfdtdl-teeqVQ 135 zebrafish
AAH93289   55 INIVLLGKTGVGKSSSGNTILGENRFACkks-lsaVTNTSSIEKSVt--------nGRSVSVIDTPGFfctkl-skeqLA 124 zebrafish
AAH95827   56 INIVLLGKTGVGKSSSGNTILGENRFTCkks-lspVTNESRIEKSDt--------nGRSVSVIDTPGFfctkl-skeqLA 125 zebrafish
Feature 1                                                            # #                      
3LXW_A     93 EERGHCYLLSAPGPHALLLVTQLGrFTAQDQQAVRQVRDMFG-EDVLKWMVIVFTRKEDLAgg----sLHDYVSntenra 167 human
CAF95106  385 AQISACVTLSSPGPHVFLFCVPLDqPAKSELQALAALEFVFGrEAVQKHTVVLFTHADQLKasekddgVEAYIAaqr-td 463 Tetraodon nigrovir...
CAF95106   84 KETQRAMTLVAPGPHAILLLVPVNqFTEMEGQVPAELKEVFG-EEVLGHTMVLLTCGDYLMgs----kEEEYLQred-pg 157 Tetraodon nigrovir...
CAF93509   82 REMRRSISLLYPGPHVFLIVIQIRkFTQREKDAVRKIKLAMG-SHALGFSVVVFTHGELLEew---tsIKHCLLdgc-td 156 Tetraodon nigrovir...
CAF95840   83 EDLSKCISYSSPGPHVFLVVIRLGrYTSEEKQTVKRIQQIFG-HEAAEYSMILFTGGDQLDer----tIEDFLDds--ve 155 Tetraodon nigrovir...
CAG01646  216 TETAKCVSLSAPGPHAFLLVVPIGqYTASENQAVCELARMFGeDAVCHHTVVLLTRGDDLQgl----eIEEYLRkap-ag 290 Tetraodon nigrovir...
AAH83287   77 KELARSVYLSAPGVHAFLFVVPYGkFTEQEEDILKRMRKVFG-EDVLEHVIILFTHGDECDre----nIQSEIDen--kv 149 zebrafish
AAH91547  136 HEVISCLSLSSPGPHAFLLVIPIErYTEEQQRTVQKILEMFH-EDISRYTILIFTHADRLNgg----sIQEFIMnqk-qk 209 zebrafish
AAH93289  125 FEFARSVYLSASGVHAFLFVVPFDrFTEQEEEILNKVEQVFG-KKVLKHVIILFTHGDECDre----nIQKEIDgn--ev 197 zebrafish
AAH95827  126 KEFARSVKLSAPGVHAFLFVVPFDrFTEQEEDILNKVEKVYG-KDVLKHLIILFTHGDEFDik----dIQSEIAgn--ev 198 zebrafish
Feature 1                     ##                                          
3LXW_A    168 LRELVAECGGRVCAFDNRat-gREQEAQVEQLLGMVEGLvle--hkgAHYSNEVYELAQV 224 human
CAF95106  464 LLKLVERCRDRFHVLEWGs--dGPEQSNVSELLEKVDQTvqe--aggQYYSCPAFKEAED 519 Tetraodon nigroviridis
CAF95106  158 LRQIIAQCGGRYHFINNRqqqnREQVQQLLEKVDGMVKEsg-----vFYMKTDQEREMEK 212 Tetraodon nigroviridis
CAF93509  157 LGQLVDGCGGRFCVFNNHs---SKNREQVSALLALVDRVlqg--negSCYGVRMLQAAED 211 Tetraodon nigroviridis
CAF95840  156 LQDLVSSCKGRYHVFNNKlkdkEENRQQVAELLQKIQTMvdt--nggSHYTSEMFQEAER 213 Tetraodon nigroviridis
CAG01646  291 LRSVIERCGGRYHVFNNRd---PSNTQQVEELLRTVDNNgestwllhQCHVFSSRSCHQG 347 Tetraodon nigroviridis
AAH83287  150 VRGVLLKCRDYHVLDNRS----LNDRQQVSELLQKIDSMvei---nqGCYTNEMYEHAQR 202 zebrafish
AAH91547  210 IQELVEKFGSRFVAFNNKn---PENREQVTRLLQKVDELmiq--nenRHFSSEVTQIMQQ 264 zebrafish
AAH93289  198 AKRVVQKCRGYHVFNNRS----LNDRQQVSELLKKIDSMk-------GCYTNKMYEYAHL 246 zebrafish
AAH95827  199 AKRVTQKCRDYHVLNNKD----LNNRQQVSDLLLKIDSMve----mkGCYTNELYECAQI 250 zebrafish

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap