2EQ6,3URH


Conserved Protein Domain Family
Lpd

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COG1249: Lpd 
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation
Statistics
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PSSM-Id: 440861
Aligned: 871 rows
Threshold Bit Score: 296.228
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2EQ6_A         4 MKTYDLIVIGTGPGGYHAAIRAAQLGLKVLAV--EA--GEVGGVCLNVGCIPTKALLHAAETLHHLKVAEgfGLKA-KPE 78 
WP_013060580   4 PVSYGLIVIGAGQGGGPLAGTVAEAGHDVALL--ER--RHVGGTCVNRGCTPTKTMIASARVAHLARRAGdyGVETgDVS 79 
WP_012792562   1 MRKFDAIVIGSGQGGVPLAKKLAKAGWQTAIV--EK--RWIGGTCINDGCTPTKSMIACGAAAHVIANSQewGITVsDFK 76 
YP_094298      2 VLEFDTIILGGGKGGKTLAMDLAKSGQKIAMV--EN--NQIGGTCINVACIPTKTLVQSAKVAHYCRKAKdyGLNTtLHP 77 
WP_015247128   4 YEEYDVVVLGSGAPGKLLAWTLASQGRRTAVV--ER--RYVGGSCPNIACLPSKNVIHGARVASYFRRGAefGITNgDWK 79 
WP_041933278   5 TQYYDDIIIGGGKAGKTLAPALVAHGRKTALV--EGslNMIGGSCINIACIPTKTLVASADIANSVRQGAayGIKTaPPT 82 
WP_015810751   1 MRHYDAIVIGAGQAGTPLCRKLAESGLKTALI--EK--RWVGGTCVNGGCSPTKAMIASAKAAWSARHNEalGVSVgGIT 76 
WP_099092099   4 PEEYDVVVLGSGASGKLIAWTLASKGKRAAVV--ER--RYVGGSCPNIACLPSKNVIQSAKVASYFRRGAefGIDAgGWK 79 
WP_012234956   3 PEQFDILVLGSGASGKHVAWHMAPAGGRTAVVewEH--RMIGGACPNTNCLPSKNEIWSAKVADLVRHAAayGTVTgPSS 80 
WP_075797898   3 MQSAETVIIGAGQAGVPLARALAAAGRDVLLI--ER--DALGGSCVNFGCTPSKAVIASARLAAQARRAAewGVTIpTVE 78 
2EQ6_A        79 LDLKKLGGWRDQVVKKLTGGVGTLLK-GNG-VELLRGFARLVGPK----EVEV--------G-GERYGAKSLILATGSEP 143
WP_013060580  80 VDLETVRQRKRDIVGMFRSGSRSSIEeKDT-LDLIEGDGRLVDPN----TVEValngdvddGgPRALTADRIVINTGTRP 154
WP_012792562  77 VDLEKIVQRKNKVVESFRGGATKGMEkTEG-LSIIYGEAVFTGEK----TLNVil----kdGgEEAITAPHIFINTGTLP 147
YP_094298     78 IDFKAIRARKDAVVKGMREANLKQFL-DSG-MDLMLGHGHFIGPK----MIEVtlssprdkQkTLHITADKIIINTGALP 151
WP_015247128  80 VDMAAVRDRKRKMVAGLVAFHLEKYR-ESG-AELVMGDGRFIAPK----TIEVtl----naGgTRTLRGQTVIIDTGSRA 149
WP_041933278  83 VDFAAVIERKRAVVEGMRAMNLNNLEkSLG-ENLIIGIARFVSSK----VIEVtt----vqGtSRLLTAERLFINTGTRP 153
WP_015810751  77 IDFEDIIERKNRIVQMMRDNSEKRIReTAG-LDLIYGTARFSGRK----EITVtl----tdGsSETLIADKFFLNNGVQP 147
WP_099092099  80 VDMGVVRDRKRAMVDGLIAMHLEKYK-ASG-AELVMGQGRFVAPK----TIEVdl----adGgTRTLRGAIVVINTGTRA 149
WP_012234956  81 VDMARVRQRKRNMVEALIAVHMERFR-ASG-ADLIIGKGRFVAPK----TLEVrs-----dGkTRVLRGDRVFLNLGTHA 149
WP_075797898  79 VDFAAVMDRARTLVAEQRGELEESFR-QPGaPRLLRGEARIEGREgsrlRLRV--------G-EAVVLADRLVLDTGSRA 148
2EQ6_A       144 LELKGFPF-GEDVWDSTRALKVEEgLPKRLLVIGGGAVGLELGQVYRRLGAEVTLIEYmPEILPQGDPETAALLRRALEK 222
WP_013060580 155 AIPPIDGLdAVDFLTSTSIMELGA-VPGHLLILGGGYIGLEFGQMFRRFGAEVTIIDRgEHVLGREDADVAGALEGILRE 233
WP_012792562 148 KIPPVPGLdTIKYLTNTSIMELTK-LPSHLVIMGSGYIGLEFGQLFRRLGSQVTIIDRgKQLLKHEDEDVAAAVKKVMET 226
YP_094298    152 FIPPIAGLdKVNYFTNDSLMNTDL-VPQHLLIIGGGYIGLEFAQMFRRFGAEVTVIEAsSEFLGREDKDIAEQVFQTLSN 230
WP_015247128 150 RMDDTTGLaEARPLTHVEALELDQ-LPEHLIVLGGGYVGLELAQAFRRFGSRVTVVERnGALIHREDPDVTDAIEHLCRD 228
WP_041933278 154 SIPPVPGLsDIGYLTSESIMELDH-LPEHLIVLGSGYIGLEFAQMFRRFGCRVTVIGQsEQILSHQDPDIAIAVQTLLER 232
WP_015810751 148 VIPDIEGIqTIPYLTSTTIMQLDE-IPEHLLILGSGYIALEFGQMFARFGSKVTLIERsERILKKEDKDITEEIAKILAQ 226
WP_099092099 150 RIDRTPGLaEARPLTHVEALELDV-APDHLLVLGGGYVGLELAQAFRRFGSRVTIVERnGALAHREDPDVSDGLRQLCED 228
WP_012234956 150 TIPDVPGLpAAGPLTHVEALELDR-LPGHLIVLGGGYVGLEFAQAYRRFGSRVTLITRaPQLAPREDPDVAGALLQIFKS 228
WP_075797898 149 ARPDLPGLdQVPLIDSRSWIDLRE-RPGHLLFLGGGTIALELAQAFRRLGSAVTIVEAgPQLTEREDPDVAEVLQRALEA 227
2EQ6_A       223 EGIRVRTKTKAVGYE-KKKDGLHVRLEP--------------AEggegeevvvdkvlvavGRKPRTEGLGLEKAGVKVdE 287
WP_013060580 234 DGIRLLNETSMTAVE-ETGGTITAHLEGddaparitgdellvAA----------------GRRPNTDALNPGAAGVATtE 296
WP_012792562 227 SGVTMHTGANVQKVE-QIGDTIRLQFTAngenltitgshllvAI----------------GRTPQSTSLQPEKAGLALdD 289
YP_094298    231 EGIQFAVDTKINAIR-QEQTEVIIEANRqgqseiirgtavlvAV----------------GRIANTAGLHLDKTGVELdE 293
WP_015247128 229 EGIEVLTRTAVDRVEgQSGESVRLHTGHggieg----thllvAG----------------GRTPNTDGIGLEKVGVETdG 288
WP_041933278 233 EGIEFLLKTKLTRVE-RSVNGIVLDLQVaqdprrlsgshllvAV----------------GRVPTTESLNLAAAGVATnT 295
WP_015810751 227 ESIEILTNTEATGFS-KNGHIISVTLETngrksqrscthvlvAA----------------GRKPQLREFGLETAGVEAdE 289
WP_099092099 229 EGIEVCTRAKITRVEgTSGASVKMHATRdgseivvegthllaAS----------------GRTPNTDGVGLEHAGVEVdG 292
WP_012234956 229 EGIEVLPSAQPVWVQgRSGDHVSVRVRSpdgeqtiegsdllvAA----------------GRTPNTAGIGLETAGVELdA 292
WP_075797898 228 DGIAVHLGAKPERVE-AGGEGVRLHLGgrmleg----thlflAA----------------GRQANTDALGLESIGLHPgE 286
2EQ6_A       288 rgFIRVNARMETSVPGVYAIGDAARPPLLAHKAMREGLIAAENAAGKDSA--FDY-QVPSVVYTSPEWAGVGLTEEEAKR 364
WP_013060580 297 qgYVQVDARLATTADGIYAIGDVTGGPAFTHVSYDDYRVLQDHWLHGGDRt-TEDrLIAYTLFTDPQLGRVGLTEKAARS 375
WP_012792562 290 kgYFKVNDQLETNVSGIYVLGDVKGGPEFTHISYNDYLVLYKRLVNKEDTs-IKDrPVPYCMFTDPQLGRIGLTEKAAKE 368
YP_094298    294 rgFIKVNEFLETTAAGIWALGDVKGGAQFTHLSLDDYRLVKHNLQNPQKKlsSQNrLIPYTVFLDPELARIGLTEAQARS 373
WP_015247128 289 krHVKVDERLQTTAEGVWAVGDCAGSPYFTHIGEDDFRVVLANLTGGD-Rv-TTGrQVPFCLFTDPELARVGLSEREARE 366
WP_041933278 296 rgFILVNERLETNIRGIWALGDINGGPQYTHISLDNYRIVKANLIDGGNRh-TGDrPVPSCLFIDPELAHVGLTETEARQ 374
WP_015810751 290 kgYIKVNDQLETSAEGIYALGDVKGGPAFTHVSYDDYRLIIQKVVEKKQIs-IADrLIPYCIFTDPQLGRVGMTEQQARE 368
WP_099092099 293 rgFVKVDERLRTTAAGVWAAGDCAGSPQFTHIAEDDFRVVLSDLAGGS-Rt-TTGrQVPYCLFTDPELARIGLSETEAKA 370
WP_012234956 293 rgYIKVNDRLETTAPDVWAMGECAGSPQFTHAAVDDFRVVRDNQAGGH-Rt-TRDrLIPFCMFTDPQLARVGLNEREAKS 370
WP_075797898 287 kgVLDVDDRLRTKADGVFAAGDIRGGPQFTHTAYDDFRVLQSLFLEDGARt-T-RrIVPYAIFTEPELGRVGLSEQEARK 364
2EQ6_A       365 AGYKVKVGKFPLAASGRALTLGGAEGMVKVVGDEETDLLLGVFIVGPQAGELIAEAALALEMGATLTDLALTVHPHPTLS 444
WP_013060580 376 RGLDVTVAQMPMTRVARALEVDETRGLMKAVIDSTTNRLLGAAVLGIEGGEVMSVLQTAMMGDLPVGRLRSAPFAHPTLA 455
WP_012792562 369 AGYDVKVACLDMTRVARAIETGNTQGFMKAVINANDDKLLGVAILGPEGGEVMSVMQMAMLGGITAKQLREMIFAHPLYS 448
YP_094298    374 QGRRIKIATIPAAAIPRAKTQGETTGILKAVIDAETDLILGVSIFCAEAGEILGVIQLAMELRVPYQKLRDMMFAHPTLV 453
WP_015247128 367 RGVGYRLAKVPMEAVFRAQTLSETRGFLKALIEEGGDRILGFTAFGAEAGEVMAVVQVAMLAGLPYTALRDAILTHPTMA 446
WP_041933278 375 KGYSIRVAKIDVSAVPRARTLSRTEGLMKAIVNAETNHILGCSLLCHEAGEVISTVQMVMQAQMPYTVLRDGVLTHPTMT 454
WP_015810751 369 KGIDIKVAVLKNDSVARSIETGDERGMMKAIVDAKTGQILGAAVLAEEGGEVITVLQMAMIGNITYDRLMNGIFAHPTYS 448
WP_099092099 371 KGIAYRLAKIPMTAVLRTWTLSEPRGFLKALVEPDGDRILGFTAFGAEAGELMAVVQVAMIAGLPYTALRDAILTHPTIA 450
WP_012234956 371 RGVEARVATLPMSDVLRAATTGETQGFMKALVDARSDRILGFTMLGAEAGEVVAVVQTAMLAGMPYTGLRDAVLTHPTMA 450
WP_075797898 365 AGRPYRLGKKPMTESGKARDIGRTEGFIKVLADPGTGEILGAAALCDSGAEVVQLFVELMNAGAGLRTMLDGVHIHPTLG 444
2EQ6_A       445 ESLMEAAEAFh-----K-Q 457
WP_013060580 456 ESLNNLFAGLdlgpaaErR 474
WP_012792562 449 ESINNLFMTLe-----K-- 460
YP_094298    454 EGINLWFAQIi-------- 464
WP_015247128 447 EGLAGLFSSVp----rG-- 459
WP_041933278 455 EGLNILFSQL--------- 464
WP_015810751 449 ESLNNLFMSLe-----G-- 460
WP_099092099 451 EGLGPLFAAVp----aGa- 464
WP_012234956 451 EGLGSLFAKVp----aRsT 465
WP_075797898 445 EAAKNAAAALd-----G-- 456
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