3V2Y


Conserved Protein Domain Family
7tmA_S1PR1_Edg1

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cd15346: 7tmA_S1PR1_Edg1 
Click on image for an interactive view with Cn3D
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors
The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).
Statistics
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PSSM-Id: 320468
Aligned: 5 rows
Threshold Bit Score: 461.268
Created: 25-Dec-2013
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:3V2Y: Human lipid-sensing GPCR, the S1P1 receptor fused to T4-lysozyme, in complex with the selective antagonist sphingolipid mimic (R)-3-amino-(3-hexylphenylamino)-4-oxobutylphosphonic acid (ML056), contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                               #   #              ##  ##
3V2Y_A        64 KLTSVVFILICCFIILENIFVLLTIWKTKKfhrPMYYFIGNLALSDLLAGVAYTANLLLSgATTYKLTpaqWFLREGSMF 143
Q9DDK4        25 KADSVVFIIVCCFIILENVLVLLTIWRTKKfhkPMYYFIGNLALSDLLAGVVYTANILLSgANTYKLTptqWFFREGSMF 104 zebrafish
NP_001086230  38 KPTSIIFIIICCFIVLENILVLLTIWRTKKfhrPMYYFIGNLALSDLLAGTAYTANILLSgPHTYKLTpveWLIREGSMF 117 African clawed ...
P21453        46 KLTSVVFILICCFIILENIFVLLTIWKTKKfhrPMYYFIGNLALSDLLAGVAYTANLLLSgATTYKLTpaqWFLREGSMF 125 human
EMP33199      44 KVTSVVFIIICCFIILENIFVLLTIWKTKKfhrPMYYFIGNLALSDLLAGVAYTANLLLSgHKTYSLTptqWFVREGSMF 123 green sea turtle
Feature 1          #                                                                 #           
3V2Y_A       144 VALSASVFSLLAIAIERYITMLKMkLHNGSNNFRLFLLISACWVISLILGGLPiMGWNCIsalssCSTVLPLYHKHYILF 223
Q9DDK4       105 VALAASVFSLLAIAIERHLTMLKMkLHNNGKTCRVFMLISTVWFIAAILGGLPvMGWNCIdsmnnCSTVLPLYHKAYILF 184 zebrafish
NP_001086230 118 VALSASVFSLVAIAIERYITMLKMkLHNGSKSSRSFLLISGCWFLALILGGLPiMGWNCIsqmsaCSTVLPLYHKHYILF 197 African clawed ...
P21453       126 VALSASVFSLLAIAIERYITMLKMkLHNGSNNFRLFLLISACWVISLILGGLPiMGWNCIsalssCSTVLPLYHKHYILF 205 human
EMP33199     124 VALSASVFSLLAIAIERYITMLKMkLHNGSNSFRSFLLISACWVISMILGGLPiMGWNCLdhlqsCSTVLPLYHKHYILF 203 green sea turtle
Feature 1        #                                                                               
3V2Y_A       224 CTTVFTLLLLSIVILYCRIYSLVRTRnifemlrideglrlkiykdtegyytigighlltkspslnaakseldkaigrntn 303
Q9DDK4       185 CTTVFSVILMAIVILYARIYALVRTRsrklvfrkv--------------------------------------------- 219 zebrafish
NP_001086230 198 CTTIFCALLMAIVILYARIYFLVRTRsrsltfkr---------------------------------------------- 231 African clawed ...
P21453       206 CTTVFTLLLLSIVILYCRIYSLVRTRsrrltfrk---------------------------------------------- 239 human
EMP33199     204 CTTVFTGLLLSIVVLYCRIYSMVRTRsrrltfrk---------------------------------------------- 237 green sea turtle
Feature 1                                                                                        
3V2Y_A       304 gvitkdeaeklfnqdvdaavrgilrnaklkpvydsldavrraalinmvfqmgetgvagftnslrmlqqkrwdeaavnlak 383
Q9DDK4           --------------------------------------------------------------------------------     zebrafish
NP_001086230     --------------------------------------------------------------------------------     African clawed ...
P21453           --------------------------------------------------------------------------------     human
EMP33199         --------------------------------------------------------------------------------     green sea turtle
Feature 1                                                          #      #                 #  # 
3V2Y_A       384 srwynqtpnrakrvittfrtgtwdayasrSSENVALLKTVIIVLSVFIACWAPLFILLLLDVGCkvktCDILFRAEYFLV 463
Q9DDK4       220 --------------------angrgsnksSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVACqtltCSILYKAEWFLA 279 zebrafish
NP_001086230 232 ---------------------nlarpsrsSEKSMALLKTVIIVLSVFILCWSPLFIFLLLDFGCkvkaCPVLFKAEYFLS 290 African clawed ...
P21453       240 ---------------------niskasrsSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCkvktCDILFRAEYFLV 298 human
EMP33199     238 ---------------------nitkatrsSEKSLALLKTVIIVLSAFIACWSPLFILLLLDVGCkvkaCSILFKAEYFLV 296 green sea turtle
Feature 1                                
3V2Y_A       464 LAVLNSGTNPIIYTLTNkeMRRAF 487
Q9DDK4       280 LAVLNSAMNPLIYTLTSneMRRAF 303 zebrafish
NP_001086230 291 LAVLNSATNPIIYTLTNreMRRAF 314 African clawed frog
P21453       299 LAVLNSGTNPIIYTLTNkeMRRAF 322 human
EMP33199     297 LAVLNSATNPIIYTLTNkeMRRAF 320 green sea turtle

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