6XP5


Conserved Protein Domain Family
Med22

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pfam06179: Med22 
Surfeit locus protein 5 subunit 22 of Mediator complex
This family consists of several eukaryotic Surfeit locus protein 5 (SURF5) sequences. The human Surfeit locus has been mapped on chromosome 9q34.1. The locus includes six tightly clustered housekeeping genes (Surf1-6), and the gene organization is similar in human, mouse and chicken Surfeit locus. The Med22 subunit of Mediator complex is part of the essential core head region.
Statistics
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PSSM-Id: 461845
Aligned: 53 rows
Threshold Bit Score: 58.7409
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6XP5_V        13 ERKNILIASIMTSYRDLITHATS------------------PITSATAspgHA-GYSSMALSTAIHAAVKYTEDLLSLTR 73  Chaetomium ther...
XP_013024715  19 ASIDGATQTLLSRFQDIADIAMNqr--------------kdKHTV---------SSEVYQIECHTLSMIRAVEQLLDISR 75 
XP_001526574  10 QKVDTIVEQLLLKFQDIFEVLKn-----------------dNKPKELL------AVESLTIENNAIQIIRLCQDMLSILR 66 
CCE62306       8 ERLGQSTELISTKLIELIKYSSVdetlee----------nedkfqENSkitSA-TTSILMVNNQTTQLIKGIQDLLVLSR 76 
XP_001643058   8 EKLGQTTELISSKLTELIKLASIesssdhneendsgyndniL---DESelsVA-TSSVLMVNNQTAQLIKGVQDLLILTR 83 
P32570         8 EKLEQTRTILSVKLAELINMTTIadrnddd---------egsfaqENSelaVA-TTSVMMVNNQTMQLIKNVQDLLILTR 77  Saccharomyces c...
XP_002553702   8 EQLERTTETLSHSLSNLIKYSSVakerddedsgeqhelpesTAKNS--------TSGLMMVNAQTAQLIKGIQDLLVMTR 79 
Q6CQN6         8 DKLDRTTETLSNTLIHLAKLSDIefggkd-----------teqprSSSglaTVsSSGVQMSNNYTMQLIKGIQDLLVITR 76  Kluyveromyces l...
EAU85676      54 KKVDVEVETLVNGMVDLVNLASIge--------------kdKFTV---------AQEAFAAQSRAESMVRAANSLLSIVH 110
ESK95359      47 KKVDLEVETLVDGMVDLVGLASIgd--------------kdKFRI---------AQESLQAQLRAESMVRAANSLLSITH 103
6XP5_V        74 TLREaLWVV----------------GPLTGPg-EKDAQAEEGMAKdaEVVWDVLNEMRD 115 Chaetomium thermophilum var. thermop...
XP_013024715  76 QLKS-FWLC----------------NSSPTTv-PSLSYNETDLVGlrTKLTS-LQNIGL 115
XP_001526574  67 SLKE-TWILqtlkvrntgdayntgnNDINGTn-NDIKDQ-RGCGEwnEEESQKVFNLFN 122
CCE62306      77 TIRE-KWLL----------------NQIPEEttEQEGIDKQELDN----LKELLKKTMN 114
XP_001643058  84 HIRE-KWLL----------------NHIPEQ-----THSGPQIDN--EELKSLLNTCMK 118
P32570        78 SIKE-KWLL----------------NQIPVT----EHSKVTRFDE--KQIEELLDNCIE 113 Saccharomyces cerevisiae S288C
XP_002553702  80 SIRE-KWLL----------------TQIPDE----GVDSQSELDY--EKCSQLLKQWTQ 115
Q6CQN6        77 SIRE-KWVL----------------SQLPEN----EELSMFESEEtlENCRKLVQESME 114 Kluyveromyces lactis NRRL Y-1140
EAU85676     111 SMKL-LLLL----------------SDESQTa-HRRDAEEKEIREanEETKRKVAALLD 151
ESK95359     104 SMKL-LLLL----------------SDEAQIa-NRRDTELNQVYQerDEAKAKVAALLD 144
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