Conserved Protein Domain Family
mug
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TIGR00584: mug 
mismatch-specific thymine-DNA glycosylate (mug)
All proteins in this family for whcih functions are known are G-T or G-U mismatch glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). Used 2pf model. [DNA metabolism, DNA replication, recombination, and repair]
Links
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Statistics
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PSSM-Id: 273154
Aligned: 3 rows
Threshold Bit Score: 455.283
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q13569   2 EAENAGsyslqqaQAFYTFp--fQQLMAEAPNMAVVNEQqm-peEVPAPAPAQEPVQEAPKGRKRKPRTTEPKQPVEPKK 78  human
P56581  26 MAEVPN-------MAVTTG----QQVPAVAPNMATVTEQ-----QVPEDAPVQEPAPEAPKRRKRKPRAAEPQEPVEPKK 89  house mouse
O59825   5 ETRDTGtkndnssEFNLSVkshkRKRSFDDENLELEESReetsgGILKKAKTQSFSESLERFRFAHAGSNNEYRKTDVVK 84  Schizosaccharomyces p...

Q13569  79 PVESK----KSGKSAKSKE-----KQEKITDTFKVKRKVDRFNGVSEAEL---LTKTLPDILTFNLDIVIIGINPGLMAA 146 human
P56581  90 PATSK----KSGKSTKSKE-----KQEKITDAFKVKRKVDRFNGVSEAEL---LTKTLPDILTFNLDIVIIGINPGLMAA 157 house mouse
O59825  85 NSDTDngllKSAVETITLEnglrnRRVNVTKKSTLKASVKKSTLKKKNEVdpaLLQGVPDYICENPYAIIVGLNPGITSS 164 Schizosaccharomyces p...

Q13569 147 YKGHHYPGPGNHFWKCLFMSGLSE--VQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQKLQKYQP 224 human
P56581 158 YKGHHYPGPGNHFWKCLFMSGLSE--VQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQKLQKYQP 235 house mouse
O59825 165 LKGHAFASPSNRFWKMLNKSKLLEgnAEFTYLNDKDLP-AHGLGITNLCARPSSSGADLRKEEMQDGARILYEKVKRYRP 243 Schizosaccharomyces p...

Q13569 225 RIAVFN-GKCIYEIFSKEVFGVKV-KNLEFGLQPHKIPDTETLCYVMPSSSARCAQFPRAQDKVHYYIKLKDLRDQLKGI 302 human
P56581 236 RIAVFN-GKCIYEIFSKEVFGVKV-KNLEFGLQPHKIPDTETLCYVMPSSSARCAQFPRAQDKVHYYIKLKDLRDQLKGI 313 house mouse
O59825 244 QVGLFIsGKGIWEEMYKMLTGKKLpKTFVFGWQPEKFGDAN--VFVGISSSGRAAGYS----------------DEKKQN 305 Schizosaccharomyces p...

Q13569 303 ERNMDVQEVQYTFDLQLAQEDAKKMAV 329 human
P56581 314 ERNADVQEVQYTFDLQLAQEDAKKMAV 340 house mouse
O59825 306 LWNLFAEEVNR-------HREIVKHAV 325 Schizosaccharomyces pombe 972h-
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