Conserved Protein Domain Family
SKA1

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pfam07160: SKA1 
Spindle and kinetochore-associated protein 1
Spindle and kinetochore-associated protein 1 (SKA1) is a component of the SKA1 complex (consists of Ska1, Ska2, and Ska3/Rama1), a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation.
Statistics
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PSSM-Id: 462107
Aligned: 34 rows
Threshold Bit Score: 183.634
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFJ46034      14 RIAELQRLSSLRl--dDQTKEYyHQDLLGLEANVQALEEQVAALKAFVQSELSVMPKVEaLIEASRIQSER-TNIVAKNL 90 
EGT56085      15 KLATYRE------------------NIPNFDPTIAHLAGSIQNIRSTLQDISKANENLKeCCEATC------ANCLPLNL 70 
Q9XWS0        15 NFRICRE------------------NIPNFETTISPLLNTMKNIKLLLDDAAFDQQKLEnNCEETC------MNCTKSQL 70  Caenorhabditis ...
A8WS92        15 KFCMYRE------------------NIPNFESTLSSITKSTNSIKILLEDISNVQKVITdPCEQSC------SSCSPNVL 70  Caenorhabditis ...
XP_006683095  34 RIQLLRELVSVHaaatSSQPTAlSHILSDLSHQISTLESQAADLQQALDTETTLLGHGRsNILPKLKQQESvLIQMLDKV 113
1_pfamImport   1 KVRELNRRVQIL----DGYDDTsEECLKLLE-SVKEIKFLISERKKILQNNQMIIEDRMqLVNRLRTLQTR-MAYMNVNY 74 
KRH76175      20 RITQLQELVIAR----NMYPASgVEDLSAVDAAVSAMELQVKAIKDRLREEALAIPKTKkLIDASLRQQKK-LQNMSLHV 94 
XP_015163390  20 RISEIQQLVVAR----NMYPASsVSDLSAIDSALKVLELQLHKIKIRMREETEAIPKAKkLIEASLRQQKK-LQNLSSVV 94 
Q9LZZ7        20 RIGELQELVIAR----NMYPAStIPDLSAIDTALSSMELQVQSIKDRLREETEAIPKAKkLIEASLKQQGK-LQKMSIYA 94  thale cress
EEF50333      20 RISELQELVIGR----NMYPASsITDLSAVDTSLKTMELQIQAIKDRLREEFEAIPKAKkLIEMSLRQQKK-LQSMSSHV 94 
EFJ46034      91 PARLPRQVACSVQgvSLAPSRPGAVgagqldalqtgsklaaGGTAAGTGVTVNGgedagrrRKEAPRWYVTEREFEAASS 170
EGT56085      71 NSLLGIKTENNRNeeAPTKIIHGDEktev---------akqNDKTNLETEKTED-------NEVRFVAQVSDQEFKTIPK 134
Q9XWS0        71 NDFLGIKVEASTIvdVKSQLVPQSKessal-------vetnEPNEQGLSSKPKE-------NDIRIVPQITDEEFKTIPK 136 Caenorhabditis ...
A8WS92        71 NKFLGIEEKLVNNveIPDSVPQKSTrpc-----------ldDEKEGSSVVQPPE-------SGNRHVQLISEQEFKSIPK 132 Caenorhabditis ...
XP_006683095 114 NAG---GTHATSTehTADVSDTLTFmkvasasdtngepdadPTSHAPKKEKPSA-------KPCRSIRLLTDDEYNHIPQ 183
1_pfamImport  75 PRGVIIFEDDRSPdrVDSVEVPSENatisqnnytspqpeadRTTLTVPTPKPRG-------DLQISVSYVSNLEFQNVPP 147
KRH76175      95 PYQMADKVTVSHLetSRCLFPEfsgqdsg-----sfealklEEEPAAVPKEKKG-------RGPPPTWYVTRSELDSLSS 162
XP_015163390  95 PSYVPDRVTKTTDdaTKCLNLEpiveds-------fvslklEE---PAPKEKKG-------RVSPPLFYISSDELNSVPP 157
Q9LZZ7        95 PSHFPDKATMLNSdlNRCLLQEnakqyeqh---stlsslkfDEEAAVLPKEKKG-------RGSPPLWYITVEELNSLSS 164 thale cress
EEF50333      95 ---LPHRMISLNLdaNKSVPPEapnqqne------fgslktENEPAPLPKEKKG-------RAPPPLWYITADELNSLPT 158
EFJ46034     171 YLRGRLQTDKVNAALDELAGHALNNSKLIAAVKgggTKLA-PADRKRATELLHSv-aMKDGIKGHYWFLESDLREG---- 244
EGT56085     135 YQLGRLTRDNLNEIVQKMDEFLMKKNQIFGKSN---KQLT-RIDRELLDNWKELelkARGRLQTTLFFVEADIRPL---- 206
Q9XWS0       137 YQLGRLTLEMMNEIVSKMDDFLMKKSKILGKTN---KQLT-RSDREVLDNWRELemkARKRLPTTLFFIETDIRPM---- 208 Caenorhabditis ...
A8WS92       133 YQLGRLTLDNLNEIVGKMDEFLTKKNAILGKTN---KQIT-RQDREVLDNWRELeikAKGRLPTTLFFIENDIRPL---- 204 Caenorhabditis ...
XP_006683095 184 YIVGRITLEKINQAITDLNLLISDKYKIFKLPQ---QKMS-KLQRSIYWEHKQL---ATAETKSRVFVTEKDLKDKsggw 256
1_pfamImport 148 YMKGRLKVTDVNKFIDAYNNTLTQKYELLKRPK---NTIKvKSELDKFINWKSQ---MNSDTAGLHFCTSDDFFTE---- 217
KRH76175     163 YMRGRLTLEKVNAAINDMVSYAEANAQLIVAPK---KKLA-ENLWEKALEIRDIa--TMEGIKGKHFFLEADIKG----- 231
XP_015163390 158 YMKQRITLEKVNAAINDMATYAEATSQLLTAPR---KKLK-ENLVERAMELRDIa--ATETVKGKHFFLETDIRG----- 226
Q9LZZ7       165 YMRGRLTLEKVNAAINDMASYAEANAHLIAASK---QKLA-ENLWEKALKLRDIv--TEQAVKGKHFFLETDMKG----- 233 thale cress
EEF50333     159 YMRGRLTLDKVNAAINDMATYAESNAHLIGASK---KKLA-ENLWEKALQVRDIa--MTETVKGKHFFLESDIKG----- 227
EFJ46034     245 --TAIKLDKTGKSMLTLLRHLGRLQEAAICH 273
EGT56085     207 --LQERLRPTFSKAIPCLRHIRRIREERCGP 235
Q9XWS0       209 --LQDRLRPSFAKAIPCLRHIRRIREERCGP 237 Caenorhabditis elegans
A8WS92       205 --LTERLRLSFAKAIPCLRHIRRVREERCGP 233 Caenorhabditis briggsae
XP_006683095 257 teSGFKFDAVGRNVVAILRHLGRIKEVRGGG 287
1_pfamImport 218 --SGIKFGKKEFSLVTVLRHTKRIREIRNKK 246
KRH76175     232 --PSLKLDNTGKAILTVLRHLGRINETRVGH 260
XP_015163390 227 --PSLKLDNTGKAILTLLRHLGRISETRIGH 255
Q9LZZ7       234 --PSLKLDNTGKAILTVLRHLGRISETRIGQ 262 thale cress
EEF50333     228 --PTLKLDNTGKAMLTVLRHLGRISETRIGP 256
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