7JRJ


Conserved Protein Domain Family
Radial_spoke

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pfam04712: Radial_spoke 
Radial spokehead-like protein
This family includes the radial spoke head proteins RSP4 and RSP6 from Chlamydomonas reinhardtii, and several eukaryotic homologs, including mammalian RSHL1, the protein product of a familial ciliary dyskinesia candidate gene.
Statistics
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PSSM-Id: 461405
Aligned: 38 rows
Threshold Bit Score: 357.347
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7JRJ_C               11 ALAYLQVHSPQDGTSMYDHLVKLVSKVLEDQPKNAV---DLLET-SLLVKKS----------TFdPK---ESSPLV-PIP 72 
XP_006681146         78 AKSFMNTVPNGKTFSLYDHLATIVNHVLQTRSPVAL---DNFETlSADLKRN----------RFrTElpgAPTSLR-ETI 143
EDW01951             94 AKSILKQYSTLSGDNLFDHISDIVKRVVDERPPNVI---DFFEEfSRNVREQ----------KFhVP---ERFPPN-GVF 156
WGS:AAQB:GK21932-PA  94 AKSIMQQYSTLSGDNLFDHISDIIKRVIDERPPNVI---DFFEEfSRNVREQ----------KFhLP---ERFPPQ-GVF 156
AAA33092             10 ALAYLQVHSPQDGTSMYDHLVKLVSKVLEDQPKNAV---DLLET-SLLVKKS----------TFdPK---ESSPLV-PIP 71 
Q4DHQ3               46 AMTGLTE-NEIRESPLWQHMKKVLLQVVQQQPSSAL---DAIIPsSFVVQTG----------SAvPP---HATTIYaDHR 108 Trypanos...
Q4DE57               17 TKAYLMN-ANKDGVSVYDQLTRLMEQLLDENPHDIAadpSRFNEiFTLLQQS----------SFvNG---QSTPAC-NEP 81  Trypanos...
EFC43249             13 AKAYLQT-TNENGKSIYDMLIDIVSYLQDHKDAKEInlkKLVEQlSEDGFKYgersgfdelwKLsKP---NPE----SCN 84 
EAX89949              8 KLEYLNTKPEGSPVSVMEHTGEVIIRLADNCAERPL---DYFEVaSYIIKEE----------RQsKE---NQELLKfGKP 71 
Q9W1D3               87 AKSILQKYSTLSGDNLFDHLSDIIKRVIDERPPNVI---DFFEEfSRNVREQ----------KFhLP---ERFPPS-GVF 149 fruit fly
7JRJ_C               73 VAPDATQT-QA----AVSIFGDPelpinpatgepvpaDPPNEFE--AE-------------------N-----------M 115
XP_006681146        144 FPSGKTELaKK----RAGLFYRQ--------------TPEEAAEkaSTdvg-------------eipD-----------I 181
EDW01951            157 ADCRMFRPaKQ----ILHSIKLPhsgenldfegdedlGGEEF----EAelri------------nidDsmrmfvtfnerV 216
WGS:AAQB:GK21932-PA 157 DESRMFRIaKT----ILQSMKLPynietedfgiqedvSAED-KTnvDDdfri------------vidDsirhfvtfnerV 219
AAA33092             72 VAPDATQTqAA-----VSIFGDPelpinpatgepvpaDPPNEFEaeN--------------------------------M 114
Q4DHQ3              109 PRVTNAVPsDA----LENLRWASsfgnvlappkprrkPTEEDEEmpQEeaeeneee----vllgevsN-----------V 169 Trypanos...
Q4DE57               82 CSVPPFELaRLadnerl--------------fdrpppETLTTIEqpDPyttv------------tttRikphtappydsV 135 Trypanos...
EFC43249             85 KAREIVEVlSK----QQNVM-KEefskrkkaieelnvKKDGDDDnqDDpveenpdimylysnedgvsN-----------L 148
EAX89949             72 KGPNFVENaKTnvrlQAQLFPKQqlgeeeeeageaegGEDAEHQeeETvneg------------eipN-----------V 128
Q9W1D3              150 DEVRSFRVaKK----ILQSMKLPyvveged-lmgedlSVEDLRT--NEdmri------------vidDsmryfvtfnerV 210 fruit fly
7JRJ_C              116 LGAAAVLDCLGVGLGRELGVNIALAAKRIGEDPKLAvrSVRFFGKFLGLYSDYFVFEVAFkkeaakeaapaapape---- 191
XP_006681146        182 MDLANLWEWAGVSFGKEETFVLFLSIKKLVEEKPLK--SVRLWGKVFGTHGNYIIVEAEIkegsadeddaianappisna 259
EDW01951            217 EQLQFYWNQCGFSISKDDIFQLASSINRLQTHPSIM--QCRFWGCISGLKASYYIVEASLsreeiasrltmmkeemrekq 294
WGS:AAQB:GK21932-PA 220 QQLQFFWNQCGFSISNDDTFQLACAMNRLQTHPSIM--QCRFWGCINGLKASYYIVEASLtreeiasrlvmmeeemrekq 297
AAA33092            115 LGAAAVLDCLGVGLGRELGVNIALAAKRIGEDPKLAvrSVRFFGKFLGLYSDYFVFEVAFkkeaakeaapaapape---- 190
Q4DHQ3              170 VGEQAIFNSVGEGLQPEEAFRLVVGMKQLVKTEPLA--TARFWGKILGSGADYYIVETKIdperlpedeedvgmaddeee 247 Trypanos...
Q4DE57              136 AQHNLYWAWAGCGVTEEEAFLLDRSITMLAMEKKLR--DVRFFGKIFGTKADYYVVSSQRyvqdgekvykevnt------ 207 Trypanos...
EFC43249            149 IEDFYALELVGVGLPHEEIAKLSVAIQNLKSSKSLR--YLRFVGKILGIESHYYVVESNYyfkekv-------------- 212
EAX89949            129 IGNMQFMNEVGVGLNETETILLQQAIQKLIRSKPLA--TARFWGKVMGIQNDYYIAEAEFndgerphaaqeeeekne--- 203
Q9W1D3              211 QQLQFYWTQCGFSISNDDIFQLASAMNRLQTHPSIM--QCRFWGCINGLKASYYIVEASLtreeiasrlvmmeeemrqkq 288 fruit fly
7JRJ_C              192 --------------------------------------------rvegeaasssapevpVEEPG-KGANKFTYLVC-SSL 225
XP_006681146        260 emtepisakds-----------------dgqekpdtknklaeeaeiglpkpktkpvkplTKEVR-VGVNKYVYYTT-PFA 320
EDW01951            295 lpfkvrknqeakpapahigpeltpgtygwelyakdelekmtpkakpvplaeeievydipPEYIG-NGCNRFSYFVV-NCL 372
WGS:AAQB:GK21932-PA 298 lplkmqknreekpapphigpeltpgiygwdnyspeelvhmkpkaaavplvqemefydipPEYIG-LGCNRFSYFVV-NSL 375
AAA33092            191 --------------------------------------------rvegeaasssapevpVEEPG-KGANKFTYLVC-SSL 224
Q4DHQ3              248 eg-----------------------------------tpidnvadvlysygakkqadteVEPAG-SGLNEWVYYAA-QTA 290 Trypanos...
Q4DE57              208 ----------------------------------------------mprparrklevpvQPEPGfVGVNRLSFWVT-SHP 240 Trypanos...
EFC43249            213 ------------------------------------------------------pqdkiHESGGkAGLNRFTYWVLrSKD 238
EAX89949            204 -------------------------------------------peegtenkedkprivpKEED--SGPNQYSYFVC-TQL 237
Q9W1D3              289 ipfpmrkdredkpppahigpeltpgiygweefppeelekmkpkaapvplveemelydipPEFIG-KGCNRYSYFVV-NSL 366 fruit fly
7JRJ_C              226 G-GPLTRLPDVTPAQVKASRRIKKLLTGRLTSHVSTYPA--FPGNEANYLRALIARISAATVVAPSDLFS---------L 293
XP_006681146        321 G-GPWTRLPDVIPELLQASRKIHKYFTGNLSAHISSYPA--FPGTESHYLRAQIARISSATVLSPNGYYM---------V 388
EDW01951            373 H-NDWIELPIVTPRQIVVSRQIKKFFTGDLEADVVSYPC--FPGKEKHYLRAVIGRITAGTYIAPQGYYRrmtkkeknlY 449
WGS:AAQB:GK21932-PA 376 Y-DDWIELPIVTPRQIVVSRQIKKFFTGDLEADVISYPC--FPGKEKHYLRAMIARITAGTYIAPQGYYRrmtkrekrlF 452
AAA33092            225 G-GPLTRLPDVTPAQVKASRRIKKLLTGRLTSHVSTYPA--FPGNEANYLRALIARISAATVVAPSDLFSln-------- 293
Q4DHQ3              291 DpTSWTRLPDVTPNQVIVARHIRRGFTGDLESSVDTHPH--FPGKEMNYLRAQIARISCACRVAPRDMYT---------- 358 Trypanos...
Q4DE57              241 A-AEWKLLPDVTPQQILAGRRIKRLFTGDLNAAVIASPP--FEWNEAVYLRVQLSRIASGTYISPMGALE---------- 307 Trypanos...
EFC43249            239 SlTNFVNLPDVTPQQINAARNISKLFTGNLEKEIISYPP--FPGNEANYLRAQIARIVHSTTIAPFDLFE---------- 306
EAX89949            238 G-GPWKLLPDITPAQIQGSRCIRQMFSGTEKGPIAA-PEgrFQGGEYELLRCFISRVTHSCTLAPKGLYN---------- 305
Q9W1D3              367 F-DDWIELPIVTPRQIVVSRQIKKFLTGDLEADVISYPC--FPGKEKHYLRTLIGRITAGTYIAPVGYYRrmtkkeqrmF 443 fruit fly
7JRJ_C              294 --------NDE-------------------------------TGELERAEDWEPPAG----------REMAapTAWVHVR 324
XP_006681146        389 --------DAEeaege----------------------esqnGASIIINPEFEGFPN----------DQLMnlTNWVHHV 428
EDW01951            450 dgin-lnqEEEeeeeeeddfn-----------egkeeesqdnDIQLMRNERFEIEPL----------STLAtpAAWVHVR 507
WGS:AAQB:GK21932-PA 453 egg---evDEEeeeeeeedfe------------geedtlddnDVMLLKNERYEMEPL----------GSLEtpIAWVHVR 507
AAA33092            294 ----------------------------------------deTGELERAEDWEPPAG----------REMAapTAWVHVR 323
Q4DHQ3              359 --------SEGavpeeedeegnvlpp--pesvkayttlppltPQEVPDEEDTEAIEPikswfygyrdDELLqgKYWVHIA 428 Trypanos...
Q4DE57              308 --------EPEeevdeeeeaeddegdaakkpreakyrpltqpVKGFASEEDSDVTQW----------AKL---DQWVHSE 366 Trypanos...
EFC43249            307 --------EREvteandeddddsnekkkkneikykevlpppvKTKAFELKDPEGMKs---------------lEHWVHLY 363
EAX89949            306 --------LEEepeegg-------------------rvenvtPIAMAEEPEYKPLEg---------------lKSFVHCV 343
Q9W1D3              444 dgeeeeegEEEeeeeeeeefn-----------egeeeqiednDVMLLKNEKYEAEPL----------GSLAtpVAWVHVR 502 fruit fly
7JRJ_C              325 PHLKS-QGRCEVH----------K--------------RELPEDADEDE-FYNED----------ELEEGPDLLAALEED 368
XP_006681146        429 PYILP-QGKVGWEnpt----arvE--------------SAEGDDEQRDD-EDAGDeggd---etvEPETGPALLTAISGD 485
EDW01951            508 SNILN-QGRVVWYdeeladkerkKalamylkmraleemGEELEEEEDAE-EEEDGeeedmlegfiHPETGPNILSSCAGD 585
WGS:AAQB:GK21932-PA 508 SNILN-QGRVVWFdeekaqkereKalahylkmrlmeemEEEIEEEEAED--EEEGdeegildhfiQPETGPSILSSCGSD 584
AAA33092            324 PHLKS-QGRCEVHk------------------------RELPEDADEDEfYNED-----------ELEEGPDLLAALEED 367
Q4DHQ3              429 PTLLQ-TGRTV-----------------------------AREQEEEDTgFD-------------HSEKIHPFLCEVSRD 465 Trypanos...
Q4DE57              367 GYIYA-NGRQTKVpekqedeeeeE--------------AEELQQQQQQEeEEEEEee-------eEEEEERELFTPINLD 424 Trypanos...
EFC43249            364 PGILK-SGFITKEpl---------------------pgDQEPADPEDDK----------------DPEV--PSFKLLQED 403
EAX89949            344 PTILD-QGRCEFY---------------------------IFEEDQQDEeGNEKEp---------VVEHGPPILTPITED 386
Q9W1D3              503 SNILNqQGRVVWYdeekarkereKalalylkmqmlgemEEEVEEEEDEEeGEEEGeeegmiegfnQPELGPSILSSCAND 582 fruit fly
7JRJ_C              369 -----------------------------------AqLPGEQAA--------------------W-----TPIYSSASEA 388
XP_006681146        486 -----------------------------------E-DHGEIPS--------------------W-----SSRVCSNLSP 504
EDW01951            586 -----------------------------------M-SNVCSIP--------------------W-----GVRFTSKHTN 604
WGS:AAQB:GK21932-PA 585 -----------------------------------T-KDEVRQP--------------------W-----LVRLTSKYTN 603
AAA33092            368 -----------------------------------AqLPGEQAA--------------------W-----TPIYSSASEA 387
Q4DHQ3              466 dpl-----------------------------tyaShSRSQLPA--------------------W-----SFRKAFHNES 491 Trypanos...
Q4DE57              425 flyavinipeppkvdeedeeeeeedddpaedaadaEkDFDDMPPkpvtdadvpdddptkvkiaaW-----TVRVVNNNSK 499 Trypanos...
EFC43249            404 dglkkckeagasp---------kkksedddndddgEnKEAKLSC--------------------WkvsfsNVRKQTCHHK 454
EAX89949            387 -----------------------------------K-SKDEYKC--------------------W-----SLREVNGVSK 405
Q9W1D3              583 -----------------------------------M-NPEVPVS--------------------W-----LARMTSKYTN 601 fruit fly
7JRJ_C              389 vKTQAGGLRSLVWPGAVCGGRGS-----E-WTCVYVGWGVK---N 424
XP_006681146        505 sKFSPVMLRSNRWPGAVVVAYND-----K-FANIYIGDGIKdlgH 543
EDW01951            605 qKERILIMQSNIWPGAFTFIFEN-----T-CESIYMGWGHK---F 640
WGS:AAQB:GK21932-PA 604 qKERMLVMQSNVWPGAFTFIFEQ-----T-CESIYLGWGHK---Y 639
AAA33092            388 vKTQAGGLRSLVWPGAVCGGRGS-----E-WTCVYVGWGVKnapf 426
Q4DHQ3              492 sKTRTYVARSATWPGAFTYAVVElgqpgSqYQSVYIGTGLKs--L 534 Trypanosoma cruzi
Q4DE57              500 -KHRVVVVRSLRWPGAVAFAAEGg----KkWGCVYFGNGLN---K 536 Trypanosoma cruzi
EFC43249            455 -SFKVVMLSSLRWQGAHTFYRNIgp--iChFGNVYIGYGIK---N 493
EAX89949            406 -RY---WLRSNVWPGLHIVSNENg----SrMVMMYFGTGMKaqkp 442
Q9W1D3              602 qKERMLVMQSNVWPGAYTFIFEK-----T-CESIYLGWGHK---Y 637 fruit fly
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