1E5P,1DZJ,1PBO,1GT5,1G85,1HN2,3FIQ,4ODD,1BJ7


Conserved Protein Domain Family
lipocalin_OBP-like

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cd19427: lipocalin_OBP-like 
Lipocalin odorant-binding protein and similar proteins
Odorant-binding proteins (OBPs) transport small hydrophobic molecules in the nasal mucosa of vertebrates. This subfamily includes mouse odorant-binding protein 1a (Obp1a), Obp1b, and probasin. Mouse Obp1a and Obp1b, which are expressed in the nasal mucosa, bind the chemical odorant 2-isobutyl-3-methoxypyrazine, and may form a OBPO1a/Opb1B heterodimer. Mouse probasin may play a role in the biology of the prostate gland. This group also includes hamster female-specific lacrimal gland protein (FLP) and aphrodisin. FLP may bind tear lipids or lipid-like pheromones found in hamster tears; aphrodisin is found in hamster vaginal discharge, carries pheromones, and stimulates copulatory behavior in males. This group also includes dog allergen Ca f4 which is expressed by tongue epithelial tissue and found in saliva and dander. Bovine OBP is believed to act as a homodimer, having the C-terminal alpha-helix of each monomer stacking against the beta-barrel of the other monomer; this is possible due to its lack of cysteines and therefore lack of disulfide bonds. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.
Statistics
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PSSM-Id: 381202
Aligned: 24 rows
Threshold Bit Score: 200.186
Created: 6-Feb-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand binding
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding cavity [chemical binding site]
Evidence:
  • Comment:hydrophobic cavity binds different hydrophobic ligands; ligands are bound within the beta-barrel in a central internal water-filled cavity lined with polar and hydrophobic amino acids
  • Comment:based on odorant-binding proteins and other lipocalin/cytosolic fatty-acid binding protein family members with structure
  • Comment:some in this group such as bovine odorant-binding protein are dimeric and lack disulfide bonds, others are monomeric and have disulfide bond(s) such as porcine odorant binding protein
  • Structure:1HN2; Bos taurus odorant binding protein homodimer bound with 1-aminoanthracene, contacts at 4A
  • Structure:1DZJ; porcine odorant binding protein bound with 4-butyl-5-propyl-1,3-selenazol-2-amine, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #   #    #             # # ## #        # # #          # # #        # # #   # 
1E5P_A         3 FAELQGKWYTIVIAADNLEKIEEGGPLRFYFRHIDCYKNCSEXEITFYVITNNQCSKTTVIGYLKg-nGTYETQFEGNNI 81  golden hamster
1HN2_A        10 LSELSGPWRTVYIGSTNPEKIQENGPFRTYFRELVFDDEKGTVDFYFSVKRDGKWKNVHVKATKQd-dGTYVADYEGQNV 88  cow
3FIQ_A         9 PSEVNGDWRTLYIVADNVEKVAEGGSLRAYFQHMECGDECQELKIIFNVKLDSECQTHTVVGQKHe-dGRYTTDYSGRNY 87  Norway rat
AAK25813      25 PSEVDGKWYSLYIAADNKEKVSEGGPLRAYIKNVECIDECQTLKITFYTKVEGVCQEHTIVGRKGe-dGKYITDFSGQNY 103 golden hamster
ADC97770      17 QAELEGKWVTTAIAADNVDKIERGGPLRLYIRKITCTEACSKMEVTFYVNENNQCSQTKITGYRQe-dGNYRAQFEGDNV 95  Bank vole
NP_001192114  21 PSEINGQWHTISIAADNVEKIGEGGPLRGYFHNLHCYDGCKNIGLTFYVKLDGNCQRFDVLGAKQedsDVYVAQYSGTNH 100 domestic guinea...
XP_003508000  17 LSELEGHWVSTAIGADNVEKIANQGTMRLYARQIICHEECDKLEITFYVNLNGQCSETTVIGYKQe-dGNYRTQFEGDNI 95  Chinese hamster
NP_001119793  22 HPELQGQWKTTAIMADNIDKIETSGPLELFVREITCDEGCQKMKVTFYVKQNGQCSLTTVTGYKQedgKTFKNQYEGENN 101 house mouse
A2AEP0        22 HPELQGQWKTTAIMADNIDKIETSGPLELFVREITCDEGCQKMKVTFYVKQNGQCSLTTVTGYKQedgKTFKNQYEGENN 101 house mouse
Q99MG7        25 PSEVDGKWYSLYIAADNKEKVSEGGPLRAYIKNVECIDECQTLKITFYTKVEGVCQEHTIVGRKGe-dGKYITDFSGQNY 103 golden hamster
Feature 1        # #       # # #           # # #                                     
1E5P_A        82 FQPLYITSDKIFFTNKNXDRaGQETNXIVVAGKGNaLTPEENEILVQFAHEKKIPVENILNILATDTC 149 golden hamster
1HN2_A        89 FKIVSLSRTHLVAHNINVDKhGQTTELTELFVKLN-VEDEDLEKFWKLTEDKGIDKKNVVNFLENENH 155 cow
3FIQ_A        88 FHVLKKTDDIIFFHNVNVDEsGKETNVILVAGKREdLNKAQKQELRKLAEEYNIPNENTQHLVPTDTC 155 Norway rat
AAK25813     104 FHIVEKSDDTMTFHNVNVDD-SGKTNVILVVGRGEsSSIEQKQRFEKTAEEYDIPKENIEDLVPTDNC 170 golden hamster
ADC97770      96 FKPVAATEDIIVFASENVDRaGRTTNLVLVAGKGQpLTPEQHEKLEAYAKEHNIPPENIRDLLATDTC 163 Bank vole
NP_001192114 101 FEVIGKKEDAIAFYNHNTDEtGKETKMIVVVARRDsLTEEEQQKLQEVAGEKGIPKDNIRYFRERDTC 168 domestic guinea pig
XP_003508000  96 FKPMVITKEFLVFISKNVDRdGLETHLLFALGKGQtLKNDQYGRLEELAKEQKIPPENIREVLTTGNL 163 Chinese hamster
NP_001119793 102 YKLLKATSENLVFYDENVDRaSRKTKLLYILGKGEaLTHEQKERLTELATQKGIPAGNLKELAHEDTC 169 house mouse
A2AEP0       102 YKLLKATSENLVFYDENVDRaSRKTKLLYILGKGEaLTHEQKERLTELATQKGIPAGNLRELAHEDTC 169 house mouse
Q99MG7       104 FHIVEKSDDTMTFHNVNVDD-SGKTNVILVVGRGEsSSIEQKQRFEKTAEEYDIPKENIEDLVPTDNC 170 golden hamster

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