6FPP,4U8T


Conserved Protein Domain Family
YTH

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pfam04146: YTH 
YT521-B-like domain
A protein of the YTH family has been shown to selectively remove transcripts of meiosis-specific genes expressed in mitotic cells. It has been speculated that in higher eukaryotic YTH-family members may be involved in similar mechanisms to suppress gene regulation during gametogenesis or general silencing. The rat protein YT521-B is a tyrosine-phosphorylated nuclear protein, that interacts with the nuclear transcriptosomal component scaffold attachment factor B, and the 68-kDa Src substrate associated during mitosis, Sam68. In vivo splicing assays demonstrated that YT521-B modulates alternative splice site selection in a concentration-dependent manner. The YTH domain has been identified as part of the PUA superfamily.
Statistics
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PSSM-Id: 461195
Aligned: 210 rows
Threshold Bit Score: 79.4639
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6FPP_B                          26 SRYFIMLCDNETAIAHAKKTS-IWAVKKDSSKRISDAYKKA--SVYFIFVAQQTYNALGYAQVV---------------- 86   Schizosaccharomyces pombe 972h-...
EGD82482                        26 CAFYLVRSHTEENIRLSQQHD-LWATPKRNMSKLKADFKNNe-NLYLIFIANGSSSYSGYARVE---------------- 87  
8_pfamImport                     1 VKYFLLQSASYLNLAHAVHHG-QWTVPAHVLQSIKTASETSe-DVFLFFAVGSSKHYQGMARLVngala----------- 67  
XP_002902266                   251 AKYFLLQSASYLNLAHSVHHE-RWAVPPAVLQQIKMASETSd-EVFLFFAVGPSKHYQGVARLVngams----------- 317 
XP_002185604                   265 AKFYIVRAATHHDLAISTVQN-EWYLQRKHAQAMNAAYQDGkhQVMIFFTVSDSNHIQGAALLT---------------- 327 
CBJ30469                       246 ARFFVLRSLNHDNLAVSAVQN-KWYARRFNIMPFNSAFDGPg-RAFFFFTVNQSNNFQGCAEMTsr-------------- 309 
EHY57751                       112 KKYFIIKSGSLDALSQSLESG-QWFIPNRHVKRLNHAFQTAe-RVYFIFSVNGSRQFFGYASMKseiqpstetsfrsndv 189 
WGS:AAGF:cds.TTHERM_00399440A  181 KKYFIIRNRNEYFRKIAQEQS-IFLIH-KNYEKLCEAFKNSd-DVYIIFSNIDQKHFYGYATMIse-------------- 243 
A0E4N3                          17 SKFFTVKYKSKAQADSSLNNKhIFIQR-KFDKLIDRAMEKSk-SVGIFLNCVDEKSFIAFGILQsqs------------- 81   Paramecium tetraurelia...
A0BNI8                          17 NKFFIIKYKTRGQADLSLNNQ-VIFLQKRFDQQLRNAAQVCe-QVGVFLSCLDQQSFIAFGTIQ---------------- 78   Paramecium tetraurelia...
6FPP_B                          87 -------------SDLNSTEL------------------------------PFWSDSSHA-------------------- 103  Schizosaccharomyces pombe 972h-...
EGD82482                        88 ----------------GMDDDi----------------------------dFDWNTSVNl-------------------- 103 
8_pfamImport                    68 --------nmeisAGEDLLTSi-----------------------------VPYEADGRStw------------------ 92  
XP_002902266                   318 --------sadasAGEDLAAGv-----------------------------VPYEADGKAew------------------ 342 
XP_002185604                   328 -------------APGVYQKS----------------------------------SDNGK-------------------- 340 
CBJ30469                       310 --------------vPQMGPRtee-------------------------------------------------------- 319 
EHY57751                       190 hrapaaieqtsqfSPVEPKRDlslvsrsrtyslassdssagsiyyeperrrVIWEAAHHDldrstipyepaspqstsqsp 269 
WGS:AAGF:cds.TTHERM_00399440A  244 ------------aDELRFISSq----------------------------lENYQNLKNKg------------------- 264 
A0E4N3                          82 ----------iqfEMLTEDQK------------------------------INLSNLKGNy------------------- 102  Paramecium tetraurelia...
A0BNI8                          79 ----------------NEPTDf-----------------------------EYLTEEQQQnls----------------- 96   Paramecium tetraurelia...
6FPP_B                         104 --------------------G------------------------------GV----RIKWIKTCNLFSAEISEIVSHMd 129  Schizosaccharomyces pombe 972h-...
EGD82482                       104 -------------------gS------------------------------TF----LVRWINTYGMPTAKASHLRNNLr 130 
8_pfamImport                    93 -------------------sG------------------------------AF----GIEWLRICECPWERLAQFENKql 119 
XP_002902266                   343 -------------------aG------------------------------SF----GIEWLRICECPWERLAQFENKql 369 
XP_002185604                   341 --------------------D------------------------------PFchriSLEWFRTTELPIETALGVASDLl 370 
CBJ30469                       320 -----------------eqvM------------------------------EF----SVKWLRLCELPFSVASQVKNPS- 347 
EHY57751                       270 latepqnvapwstsmpttrvSppggqavsffspfspfddprseavprsdlvPFsspcPVKWLSVNNISFDSVRGLTNAW- 348 
WGS:AAGF:cds.TTHERM_00399440A  265 --------------------E------------------------------EYimysKIQWSSQTPLHYDHCKNILNPW- 293 
A0E4N3                         103 -------------------eS------------------------------FF----KVDWTLKGVLSYEKTQKIKNVL- 128  Paramecium tetraurelia...
A0BNI8                          97 -----------------klqE------------------------------FFqsfvKVEWIFKGVLNFEKTKNIKNDL- 128  Paramecium tetraurelia...
6FPP_B                         130 HG----SEARDGMEMMYDEGSRLCTLIN 153  Schizosaccharomyces pombe 972h-
EGD82482                       131 Rrq-eiHKCPDMTKIESVAAAKLLTLMD 157 
8_pfamImport                   120 ----avSECPNGQELDADTGHALVRLLS 143 
XP_002902266                   370 ----avSECPNGQELDAETGHALVRLLF 393 
XP_002185604                   371 l---ptSSTQYCQDMSSTTGESLMKAIW 395 
CBJ30469                       348 QDnlpiWRASHGMEIPYEAGRKLCKLMW 375 
EHY57751                       349 NGnkdiYVARNVTAVDPSAAAVLLQLFQ 376 
WGS:AAGF:cds.TTHERM_00399440A  294 NSnkpiNFSKEFQEVEPAAALQLLELLD 321 
A0E4N3                         129 NDllpvNQGKEVEELSGSNAEEVLTYRN 156  Paramecium tetraurelia
A0BNI8                         129 NEmkpvNHCKDVQELTCQTAEQLLSLLQ 156  Paramecium tetraurelia
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