1JG5


Conserved Protein Domain Family
GFRP
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pfam06399: GFRP 
GTP cyclohydrolase I feedback regulatory protein (GFRP)
Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in via feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by the regulatory subunit called GTP cyclohydrolase I feedback regulatory protein (GFRP).
Links
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Statistics
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PSSM-Id: 461897
Aligned: 13 rows
Threshold Bit Score: 122.841
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1JG5_A         1 PYLLISTQIRMEVGPTMVGDEHSDPELMQQLGASKRRVLGNNFYEYYVNDPPRIVLDKLECRGFRVLSMTGVGQTLVWCL 80 
EDO32067       2 PYILISTRIRLELGPTQCGDEWSDPELMALLDAELVHQFGNNFKEYLSKHPPRVVLNKLGKIGYKVISSTGIGQTIVWTL 81 
EEN52803       2 PYLLISTQIRMECGPTIVGDVESDKDLMEYLGATLQQMLGNNFKEWRTPKSPRVVLDLLERRGWRVVGMTGIGQTCAWTL 81 
EEC01831       2 PYLLVWSQVPGAA-PTYL-DGSQDPALLKELGGKVNKPVFSKRTLVKVDDTPCSVLNKLEVMGYKVLAVSGDTLGTVWTV 79 
XP_002407324   2 PYLLVWSQVRGQL-PTYL-DGSQDPALLKQLGAKVTKPLMVKRATVHTDDSPGSVLNKLEGMGYKVVAVSGNPLGTVWTV 79 
XP_004010500   2 PYLLISTQIRMEVGPTMVGDEYSDPELMQHLGASKRSVLGNNFSEYYVNDPPRIVLDKLERRGFRVLSMTGVGQTLVWCL 81 
OWK57433       2 PYLLISTQIRLEAGPTMVGDEHSDPHLMSILGATKRTTLGNNFCEYYVNDAPRMVLDKLESLGYRVVSMTGVGQTLVWCL 81 
Q6NVA8         2 PYVLISTQIRMETGPTIVGDEFSDTQLMAQLEADKRTVLGNNFSEYCVNEPPRVTLNKLEKLGYRVVSMTGVGQTLVWCL 81  tropical clawed...
Q6PBT6         2 PYILISTQIRLETGPTMVGDEYSDPSIMNYLGARKITVLGNNFSEYHVDEPPRLVLDKLDKIGYRVVSMTGVGQTLVWCL 81  zebrafish
3_pfamImport   1 PYVLISTLIRLEIGPTIVGDEHSDVALMKELGATLHHRAGNPFKEWSVEDPPRIVLDKLEVLGYKLVGTTGIGQTAIWTL 80 
XP_003386516   3 QYVLITTQIRLENGPTICGDELSDPVLMAKLDAQLVRDAGNPFQVYSSPHPPRVILNKLACEGFRVVSMAGIGQTCIWTL 82 
EFB24969       2 phplssTQIHTEVGPTPLGDGHSAPELMWYLGASKRSVLGNHFCEYFISDPPCMVLDKLECKGFHVLSKREVGWTLVWCL 81  giant panda
PIC35261       2 PYILISTQIRMECGPTMVGDGESDAKLMEKLEAKLMKQLGNEFQEYITKWSPRKVLNQLEKEGWQVVAMAGIGQTCAWTL 81  Caenorhabditis ...

1JG5_A        81 HKE 83 
EDO32067      82 FKP 84 
EEN52803      82 HKP 84 
EEC01831      80 HKS 82 
XP_002407324  80 HKS 82 
XP_004010500  82 HKE 84 
OWK57433      82 HRE 84 
Q6NVA8        82 HKE 84  tropical clawed frog
Q6PBT6        82 HKE 84  zebrafish
3_pfamImport  81 HKP 83 
XP_003386516  83 YLE 85 
EFB24969      82 HKD 84  giant panda
PIC35261      82 YKa 84  Caenorhabditis nigoni
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