1V8B,3N58,3MTG


Conserved Protein Domain Family
AdoHcyase

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smart00996: AdoHcyase 
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S-adenosyl-L-homocysteine hydrolase
Statistics
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PSSM-Id: 214963
Aligned: 78 rows
Threshold Bit Score: 684.658
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1V8B_A         7 KVKDISLAPFGKMQMEISENEMPGLMRIREEYGKDQPLKNAKITGCLHMTVECAL-------------------LIETLQ 67  Plasmodium falc...
NP_958497    167 CIKNIKQADFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKIVGCTHITAQTAV-------------------LMETLS 227 zebrafish
EAA06910      33 CVRNIKQHSFGRHEIEIAEQEMPGIMALRKQALDDKPLKGANIVGCTHVNAQTAV-------------------LIETLI 93  Anopheles gambi...
CAG07497      69 CVKNIKQAEFGRREIEIAEQDMSALISLRKRAQGEKPLAGANIVGCTHITAQTAV-------------------LIETLV 129 spotted green p...
YP_001219520  12 KVADMKLADYGRKEIELAEAEMPTLMALREKYKSKQPLKNAKILGCIHMTIQTAV-------------------LIETLI 72  Candidatus Vesi...
YP_610454     14 KVADISLADWGRKEVIIAESEMPALMGLRRKYQAEQPLKGAKIIGCIHMTIQTAV-------------------LIETLV 74  Pseudomonas ent...
YP_046892     19 KVADISLADYGRKEIKLAEAEMPALIGLRKRYAAEKPLAGAKILGCIHMTIQTAV-------------------LIETLV 79  Acinetobacter s...
YP_264255     21 KVADISLADYGRREITLAEAEMPALMGLRRRYEADQPLKGAKIAGCIHMTIQTAV-------------------LIETLV 81  Psychrobacter a...
CAG12135      66 CIKNIKQADFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKVVGCTHITAQTAVsedhhsgplwgpadpaesvLMETLS 145 spotted green p...
CAG03404      63 CVKNIKQAHLGRREIEIAEQDMAALMFLRTRAGAEKPLAGAKVMGCTHITAQTAV-------------------LIETLS 123 spotted green p...
1V8B_A        68 KLGAQIRWCSCNIYSTADYAAAAVSTlENVTVFAWKNETLEEYWWCVESALTW-Gdg---ddNGPDMIVDDGGDATLLVH 143 Plasmodium falc...
NP_958497    228 ALGAQCRWAACNIYSTQNEVAAALAE-GGFSVFAWKGESEDDFWWCIDRCVNV-Eg------WQPNMILDDGGDLTHWIY 299 zebrafish
EAA06910      94 CLGANVRWAACNIYSTQNEVAAALAE-SGVPIFAWRGEIEEDFWWCIDKCVHA-En------WQPNMILDDGGDATHLML 165 Anopheles gambi...
CAG07497     130 ALGAQCRWTACNIYSTQNEVAAALAE-TGVPVFAWKGESEDDFWWCIDRCVNMd-------gWQANMVLDDGGDLTHWVY 201 spotted green p...
YP_001219520  73 DLGSQVRWSSCNIFSTQDHAASAMVA-ANIPIFAWKGETEEEFLWCIEQTILKnGk-----pWAANMVLDDGGDLTQILH 146 Candidatus Vesi...
YP_610454     75 ALGAEVRWSSCNIFSTQDQAAAAIAA-AGIPVFAWKGETEQEYEWCIEQTILK-Dgq----pWDANMVLDDGGDLTEILH 148 Pseudomonas ent...
YP_046892     80 ELGAEVRWTSCNIFSTQDHAAAAIAA-SGVPVFAWKGETEEEYNWCLEQQINVnGk-----pWDANMILDDGGDLTALVH 153 Acinetobacter s...
YP_264255     82 ALGAEVRWTSCNIFSTQDHAAAAIAA-AGISVYAWKGETEEEYEWCLRQQVHV-GgeesgqlWDTNLILDDGGDLTALIH 159 Psychrobacter a...
CAG12135     146 ALGAQCRWAACNIYSTQNEVAAALAE-GGFNVFAWKGESEDDFWWCIDRCVNV-Eg------WQPNMILDDGGDLTHWIY 217 spotted green p...
CAG03404     124 VLGAQCRWAACNIFSTQNAVAAALAE-AGRRC------------------------------STHTRVCEDAGLLQCSVS 172 spotted green p...
1V8B_A       144 KgveyeklyeeknilpdpekakneeercfltllknsilknpkKWT----NIAKKIIGVSEETTTG--------------- 204 Plasmodium falc...
NP_958497    300 K-----------------------------------------KYP----NMFKKIKGIVEESVTG--------------- 319 zebrafish
EAA06910     166 K-----------------------------------------KYP----VMFKMIKGIVDESVTG--------------- 185 Anopheles gambi...
CAG07497     202 K-----------------------------------------KYP----SVFKKVRGIVEESVTG--------------- 221 spotted green p...
YP_001219520 147 E-----------------------------------------KYP----EMLANIHGISEETTTG--------------- 166 Candidatus Vesi...
YP_610454    149 K-----------------------------------------KYP----AMLEKIHGVTEETTTG--------------- 168 Pseudomonas ent...
YP_046892    154 E-----------------------------------------KYP----TLLDHIHGITEETTTG--------------- 173 Acinetobacter s...
YP_264255    160 N-----------------------------------------DYA----ELLDNIHGISEETTTG--------------- 179 Psychrobacter a...
CAG12135     218 K-----------------------------------------KYP----NMFKKIKGIVEESVTG--------------- 237 spotted green p...
CAG03404     173 P-----------------------------------------HLPlcvfQAQRCLRGGDRRRTTSggalrnvwalrsgnp 211 spotted green p...
1V8B_A       205 ----VLRLKKMDKQNELLFTAINVNDAVTKQKYDNVYGCRHSLPDGLMRATDFLISGKIVVICGYGD------------- 267 Plasmodium falc...
NP_958497    320 ----VHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQVVVCGYGE------------- 382 zebrafish
EAA06910     186 ----VHRLYQLSKTSKLTVPAMNVKDAITKTKFDSLYSCKESVIDSLKRATDIMIGGKQIVLCGYGE------------- 248 Anopheles gambi...
CAG07497     222 ----VHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDIMFGGKQVVVCGYGE------------- 284 spotted green p...
YP_001219520 167 ----VHRLLEMMKEGSLKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRSTDMLMSGKKVLVIGYGD------------- 229 Candidatus Vesi...
YP_610454    169 ----VHRLLDMLAKGELKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLLSGKQALVIGYGD------------- 231 Pseudomonas ent...
YP_046892    174 ----VQRLLEMWKDGSLKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRATDMLLSGRRALVIGYGD------------- 236 Acinetobacter s...
YP_264255    180 ----VHRLVEMLNKGTLKVPAINVNDAVTKSKNDNKYGCRHSLNDAIKRATDMFLAGRRALVIGYGD------------- 242 Psychrobacter a...
CAG12135     238 ----VHRLYQLSKAGKLSVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQVVVCGYGE------------- 300 spotted green p...
CAG03404     212 twyqNQRLYQLSKAGKLCLPAFNVNDCVTKQKFDSLYCCKESVLSGLKRTTDVMFGGKQVLVCGYGEvgeadqltsclaq 291 spotted green p...
1V8B_A       268 VGKGCASSMKGLGARVYITEID----------P------ICAIQAV--------------------MEGFNVVTL----- 306 Plasmodium falc...
NP_958497    383 VGKGCSAALKAMGSIVYVTEID----------P------ICALQAC--------------------MDGFRLVKL----- 421 zebrafish
EAA06910     249 VGKGCAQALKGLGCIVYVTEID----------P------ICALQAC--------------------MDGFRVVKL----- 287 Anopheles gambi...
CAG07497     285 VGKGCCTALKALGAIVCVTEID----------P------ICALQAC--------------------MDGFKVVKL----- 323 spotted green p...
YP_001219520 230 VGKGSAQSLRQENMIVKISEID----------P------ICAMQAC--------------------MDGFEIISPyingi 273 Candidatus Vesi...
YP_610454    232 VGKGSAQSLRQEGMIVKVTEVD----------P------ICAMQAC--------------------MDGFEVVSPfkdgi 275 Pseudomonas ent...
YP_046892    237 VGKGSAQSLRQEGMIVRVTEVD----------P------ICAMQAC--------------------MDGYEVVSPykngv 280 Acinetobacter s...
YP_264255    243 VGKGSTQSLRQEGMIVRVSEVD----------P------ICAMQAC--------------------MDGFEVLSPyingd 286 Psychrobacter a...
CAG12135     301 ---PCDLSLPGGERLLRRPQSDglhrlrhrdrPhlclagLVRLQLCrdglwartrshlcirsllssMDGFRLVKL----- 372 spotted green p...
CAG03404     292 VGKGCCAALKAVGAVVYVTEAD----------P------ICALQAC--------------------MDGFRVVRM----- 330 spotted green p...
1V8B_A       307 ---------DEIVDKGDFFITCTGNVDVIKLEHLLKMKNNAVVGNIGHFDDEIQVNELFNYKgihIENVKPQVDRITL-- 375 Plasmodium falc...
NP_958497    422 ---------SEVIRQVDIVITCTGNKNVVVREYMDRMKNGCIVCNMGHSNTEIDVASLRT-PeltWERVRSQVDHVIW-- 489 zebrafish
EAA06910     288 ---------NEVIRTVDVVITCTGNKNVVTREHMDKMKNGCIVCNMGHSNTEIDVNSLRT-SelqWEKMRSQVDHIIWp- 356 Anopheles gambi...
CAG07497     324 ---------SEVIRQMDVVITCTGNKNVVTREQLDRMKNGCIVCNMGHYNTEIDVASLR-SPeltWERVRSQVDHIIW-- 391 spotted green p...
YP_001219520 274 ntglidninKDLLNTTDLIVTATGNINVCDNTMLQTLKPGAVVCNIGHFDNEIDTQYMRDNw--rWDEIKPQVHRIFR-- 349 Candidatus Vesi...
YP_610454    276 ntgteaginKDLLGRIDLIVTTTGNVNVCDANMLKALKKRAVVCNIGHFDNEIDTAFMRKHw--aWEEVKPQVHKIHRtg 353 Pseudomonas ent...
YP_046892    281 qtgkkedinLDLLKNTDLIVTTTGNYHVCDSAMLDTLKAGAVVCNIGHFDTEIDTNYLRgy---kWVEVKPQVHQVYR-- 355 Acinetobacter s...
YP_264255    287 ntggaeninTRLLEDTDMIVTTTGNYHVCDRHMLAALKPGAVVCNIGHFDTEIDTQFMRDNw--rWVEIKPQVHQIFR-- 362 Psychrobacter a...
CAG12135     373 ---------NEVIRQVDIVITCTGNKNVVVRENLDRMKNGCIVCNMGHSNTEIDVASLRT-PeltWERVRSQVDHVIW-- 440 spotted green p...
CAG03404     331 ---------EEVAAQVDVVITCTGNKNVVVRKHLDRMKNGCIVCNMGHSNTEIDLASLRT-AelrWERVRSHVDHVIW-- 398 spotted green p...
1V8B_A       376 ------P--N--GN--KIIVLAR---------------------------------------GRLLNLGCATGHPAFVMS 404 Plasmodium falc...
NP_958497    490 ------P--D--GK--RIVLLAE---------------------------------------GRLLNLSCST-VPTFVLS 517 zebrafish
EAA06910     357 -----gP--D--GK--RIILLAE---------------------------------------GRLVNLSCSS-ISSFVAS 385 Anopheles gambi...
CAG07497     392 ------P--D--GK--RVVLLAEvifkmhlptlmsemenedvycgilnpvlnlrgtcalvsqGRLLNLSCST-VPTFVLS 458 spotted green p...
YP_001219520 350 ------T--D--NKndYLILLSE---------------------------------------GRLVNLGNATGHPSRIMD 380 Candidatus Vesi...
YP_610454    354 agtfdpQ--N--DD--YLILLAE---------------------------------------GRLVNLGNATGHPSRIMD 388 Pseudomonas ent...
YP_046892    356 ------SenE--ND--YLILLSE---------------------------------------GRLVNLGNATGHPSRVMD 386 Acinetobacter s...
YP_264255    363 ------S--DdeND--YLILLAE---------------------------------------GRLVNLGNATGHPSRVMD 393 Psychrobacter a...
CAG12135     441 ------P--D--GK--RIVLLAE---------------------------------------GRLLNLSCST-VPTFVLS 468 spotted green p...
CAG03404     399 ------P--D--GK--RILLLAE---------------------------------------GRLLNLSCST-VPSIVLS 426 spotted green p...
1V8B_A       405 FSFCNQT-------------------------FAQLDLWQ-N--------K-DtnKYENK-------VYLLPKHL----- 437 Plasmodium falc...
NP_958497    518 ITATTQA-------------------------LALIELYN-A--------PeG--RYKQD-------VYLLPKKM----- 549 zebrafish
EAA06910     386 ISATTQA-------------------------LALIELFN-Ap-------P-G--RYKAD-------VYLLPKKM----- 417 Anopheles gambi...
CAG07497     459 ITATTQVgsvvasppvavllpvviqpfsalqaLALIELFN-A--------PvG--RYKQD-------VYLLPKKMgeplf 520 spotted green p...
YP_001219520 381 GSFANQV-------------------------LAQIHLFN-A--------K-F--ADNGGni----yVKVLPKKL----- 414 Candidatus Vesi...
YP_610454    389 GSFANQV-------------------------LAQIFLFE-Qkfa---elP-A--AKKAErl----tVEVLPKKL----- 427 Pseudomonas ent...
YP_046892    387 GSFANQV-------------------------LGQIHLFQ-EkfadlpasE-K--AAQIR-------VEVLPKKL----- 425 Acinetobacter s...
YP_264255    394 GSFANQV-------------------------LAQMYLFEdK--------F-A--DLPADkrtdnlyVKVLPKKL----- 432 Psychrobacter a...
CAG12135     469 ITATTQA-------------------------LALIELYN-A--------PeG--RYKQD-------VYLLPKKM----- 500 spotted green p...
CAG03404     427 ITTTTQA-------------------------LALMELYS-A--------PeG--RYKQD-------IYLLPKKT----- 458 spotted green p...
1V8B_A       438 ------------------------DEKVALYHLKKLNASLTELDDNQCQFLGVNKSGPFKSNEYR 478 Plasmodium falciparum 3D7
NP_958497    550 ------------------------DEYVASLHLPTFDAHLTELSDEQAKYLGLNKNGPFKPNYYR 590 zebrafish
EAA06910     418 ------------------------DEYVASLHLQTLDAHLTELTDEQARYMGLNKAGPFKPNYYR 458 Anopheles gambiae str. PEST
CAG07497     521 frihccsfwgdgipdcvdvsslssDEYVASLHLPIFDAHLTELSDEQAKYMGLNKNGPFKPNYYR 585 spotted green pufferfish
YP_001219520 415 ------------------------DEEVAAGMVYGFNGVLTILTTNQANYINVPKNGPFKPENYK 455 Candidatus Vesicomyosocius oku...
YP_610454    428 ------------------------DEEVALEMVRGFGGVVTQLTPQQAEYIGVTVEGPFKPDAYR 468 Pseudomonas entomophila L48
YP_046892    426 ------------------------DEEVAAAMVLGFGGVLTQLTSVQADYLGVPVEGPFKSDAYK 466 Acinetobacter sp. ADP1
YP_264255    433 ------------------------DEEVAAAMVAGFNGTLTKLTEKQAEYLGVPIEGPFKPDAYK 473 Psychrobacter arcticus 273-4
CAG12135     501 ------------------------DEYVASLHLPTFDAHLTELSDEQAKYLGLNKNGPFKPNYYR 541 spotted green pufferfish
CAG03404     459 ------------------------DEFVAALHLPTFDAHLTELSEEQARYLGVSKTGPFKPHHYR 499 spotted green pufferfish
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