Conserved Protein Domain Family
beta-trefoil_FGF

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cl00060: beta-trefoil_FGF Superfamily 
FGF domain, beta-trefoil fold, found in acidic and basic fibroblast growth factor (FGF) superfamily
The FGF superfamily includes FGF1-23 and similar proteins. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. They play essential roles in patterning and differentiation during vertebrate embryogenesis and have neurotrophic activities. FGFs have a high affinity for heparan sulfate proteoglycans and require heparan sulfate to activate one of four cell surface FGF receptors. Upon binding to FGF, the receptors dimerize, and their intracellular tyrosine kinase domains become active. The structure of FGFs is typical of the beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.
Links
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Taxonomy: root
PubMed: 169 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl00060
PSSM Id: 469595
Name: beta-trefoil_FGF
Created: 8-Feb-2008
Updated: 4-Oct-2023
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