6ZH3


Conserved Protein Domain Family
Snf7

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pfam03357: Snf7 
Snf7
This family of proteins are involved in protein sorting and transport from the endosome to the vacuole/lysosome in eukaryotic cells. Vacuoles/lysosomes play an important role in the degradation of both lipids and cellular proteins. In order to perform this degradative function, vacuoles/lysosomes contain numerous hydrolases which have been transported in the form of inactive precursors via the biosynthetic pathway and are proteolytically activated upon delivery to the vacuole/lysosome. The delivery of transmembrane proteins, such as activated cell surface receptors to the lumen of the vacuole/lysosome, either for degradation/downregulation, or in the case of hydrolases, for proper localization, requires the formation of multivesicular bodies (MVBs). These late endosomal structures are formed by invaginating and budding of the limiting membrane into the lumen of the compartment. During this process, a subset of the endosomal membrane proteins is sorted into the forming vesicles. Mature MVBs fuse with the vacuole/lysosome, thereby releasing cargo containing vesicles into its hydrolytic lumen for degradation. Endosomal proteins that are not sorted into the intralumenal MVB vesicles are either recycled back to the plasma membrane or Golgi complex, or remain in the limiting membrane of the MVB and are thereby transported to the limiting membrane of the vacuole/lysosome as a consequence of fusion. Therefore, the MVB sorting pathway plays a critical role in the decision between recycling and degradation of membrane proteins. A few archaeal sequences are also present within this family.
Statistics
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PSSM-Id: 460896
Aligned: 32 rows
Threshold Bit Score: 111.175
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6ZH3_B  22 RIRSVLRKNGRNIEKSLRELTVLQNKTQQLI----KKSAKKND-----VRTVRLYAKELYQINKQYDRMYTSRAQLDSVR 92  Saccharomyces cerevis...
Q03390  19 ESNQSMNQAQQSLSNRISQLDTQIAQLNFQLqniqKNLQRSNNkqpslRKQALKILNKRKQLENMKDSLDSQSWSMTQAQ 98  Saccharomyces cerevis...
Q22718 216 ASVVDIRKAMNKLDREIQQLEQKVKKYDEQC----RACLRTGD-----KGRAQNFLRQRKRAEKDIADKDVQYQKLLTML 286 Caenorhabditis elegans
Q9UQN3  16 EQNRELRGTQRAIIRDRAALEKQEKQLELEI----KKMAKIGN-----KEACKVLAKQLVHLRKQKTRTFAVSSKVTSMS 86  human
Q9VRJ5  18 ENDRSLRKATRDIERERRKMEEEERKLELEI----RRNAAAGN-----NDACRILAKQLVEIRKQKSRTYAAAGKIQSIG 88  fruit fly
Q941D5  16 ESKREMTQATRGIEKEIGSLQSEEKKLVLEI----KRTAKSGN-----EGATKILARQLIRLRQQIANLQGSRAQMRGIA 86  thale cress
Q9SKI2  18 ENKRMLDKSIREIERERQGLQTQEKKLINEI----KKTAKQGQ-----MGAVKVMAKDLIRTRHQIEKFYKLKSQLQGVS 88  thale cress
O43633  17 QNQRALNRAMRELDRERQKLETQEKKIIADI----KKMAKQGQ-----MDAVRIMAKDLVRTRRYVRKFVLMRANIQAVS 87  human
Q9VBI3  17 KNQRALNKAMRDLDRERMKMEQQEKKIIADI----KKMAKEGQ-----MDAVKIMAKDLVRTRRYAKKFMLMKANIQAVS 87  fruit fly
Q9VN02  18 EWTHKIRKEGNQLDRQIRSIQREEEKVKRSL----KQAAQKND-----RDTCVILAKEIVNARKAINRIYTSKAHLNSIQ 88  fruit fly
6ZH3_B  93 MKIDEAIRMNTLSNQMADSAGLMREV--NSLVRLPQLRNTMIELEKELMKSGIISEMVDDTMESVgdvGEEMDEAVDEEV 170 Saccharomyces cerevis...
Q03390  99 LTNDNLQNTMITINALKQTNNAMKAQ--YGKINIDKLQDMQDEMLDLIEQGDELQEVLAMNNNSGe-lDDISDAELDAEL 175 Saccharomyces cerevis...
Q22718 287 HQISSAKNNKDVLQAYKSGTAAFKATlaRQGLSPDKIHETMDDVVNSMDEYKEIEEAISSPFVNA---NGFNDADLEQEL 363 Caenorhabditis elegans
Q9UQN3  87 TQTKVMNSQMKMAGAMSTTAKTMQAV--NKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIf-dGSDDEEESQDIV 163 human
Q9VRJ5  89 YQNKNMGANIALSEAMGTTAKTMGEM--NKVMRPEAIGETVRQFQAANMKMEMTDEMINDTLDDMl-nESGDEEESNAVV 165 fruit fly
Q941D5  87 THTQAMHAHTSVAAGMQGATKAMAAM--SKNMDPAKQAKVMREFQKQSAQMDMTTEMMSDSIDDAl-dNDEAEDETEDLT 163 thale cress
Q9SKI2  89 LRIQTLKSTQAMGEAMKGVTKAMGQM--NRQMNLPSLQKIMQEFERQNEKMEMVSEVMGDAIDDAl-eGDEEEEETEDLV 165 thale cress
O43633  88 LKIQTLKSNNSMAQAMKGVTKAMGTM--NRQLKLPQIQKIMMEFERQAEIMDMKEEMMNDAIDDAm-gDEEDEEESDAVV 164 human
Q9VBI3  88 LKIQTLKSQNTMAQAMKGVTKAMQNM--NRQLNLPQIQKILQDFEKQSEMMDMKEEMINDAIDDAm-eDEGDEEETDAVV 164 fruit fly
Q9VN02  89 MQMKNQLSTLRVAGSLQKSTEVLQAM--QSLVRYPELAGIMRDMSKEMMKAGIIEEMLDETMDSLe-eSEELEEEASKEV 165 fruit fly
6ZH3_B 171 NKIVEQYTNEK--------FKNVDQVPTVE 192 Saccharomyces cerevisiae S288C
Q03390 176 DALAQE--DFTlptsenslGNDMPSYLLGA 203 Saccharomyces cerevisiae S288C
Q22718 364 EDLISDNKKNE--------SVHLPEAPTNR 385 Caenorhabditis elegans
Q9UQN3 164 NQVLDEIGIEI--------SGKMAKAPSAA 185 human
Q9VRJ5 166 NKVLDEIGIEI--------SGKMSSIPATG 187 fruit fly
Q941D5 164 NQVLDEIGIDI--------ASQLSSAPKGK 185 thale cress
Q9SKI2 166 SQVLDEIGIDI--------NQELVNAPSGA 187 thale cress
O43633 165 SQVLDELGLSL--------TDELSNLPSTG 186 human
Q9VBI3 165 SQVLDELGLQL--------GEQLGDLPSAS 186 fruit fly
Q9VN02 166 DKVLWEITDGK--------LGEAPLPPEAT 187 fruit fly
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