6QWL


Conserved Protein Domain Family
Flu_PB1

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pfam00602: Flu_PB1 
Influenza RNA-dependent RNA polymerase subunit PB1
Two GTP binding sites exist in this protein.
Statistics
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PSSM-Id: 395479
Aligned: 5 rows
Threshold Bit Score: 1025.58
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6QWL_K   1 M-------NINPYFLFIDVPIQAAISTT----FPYTGVPPYSHGTGTGHTIDTVIRTHE--YSNKGKQYVSDVTGCTMVD 67 
P07832   1 M-------NINPYFLFIDVPIQAAISTT----FPYTGVPPYSHGTGTGYTIDTVIRTHE--YSNKGKQYISDVTGCVMVD 67  Influenza B virus (B/...
Q6I7C3   1 M-------EINPYLMFLNNDVTSLISTT----YPYTGPPPMSHGSSTKYTLETIKRTYD--YSRTSVEKTSKVFNIPRRK 67  Influenza C virus (C/...
O41353   1 MnlftprsEINP-------------TTTqellYAYTGPAPVAYGTRTRAVLENIIRPYQyfYKEPNVQRALDIK------ 61  Thogoto virus (isolat...
P03431   1 M-------DVNPTLLFLKVPAQNAISTT----FPYTGDPPYSHGTGTGYTMDTVNRTHQ--YSEKGRWTTNTETGAPQLN 67  Influenza A virus (A/...
6QWL_K  68 PTNGPLPED---NEPSAYAQLDCVLEALDRMDEEH-PGLFQAASQNAMEALMVTTVDKLTQGRQTFDWTVCRNQPAATAL 143
P07832  68 PTNGPLPED---NEPSAYAQLDCVLEALDRMDEEH-PGLFQAGSQNAMEALMVTTVDKLTQGRQTFDWTVCRNQPAATAL 143 Influenza B virus (B/...
Q6I7C3  68 FCNCLEDKDe-lVKPTGNVDISSLLGLAEMMEKRMgEGFFKHCVMEAETEILKMHFSRLTEGRQTYDWTSERNMPAATAL 146 Influenza C virus (C/...
O41353  62 -TGCKEPEDinvEGPSSGFHTASVLKLADNFFRKYrPAM-EKLKYWILVKLPKLKYAELSKGRQTYSFIHKRNLPAPIAL 139 Thogoto virus (isolat...
P03431  68 PIDGPLPED---NEPSGYAQTDCVLEAMAFLEESH-PGIFENSCIETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATAL 143 Influenza A virus (A/...
6QWL_K 144 NTTITSFRLNdLNGADKGGLVPFCQDIIDSLDKPEMTFFSVK-----NIKKKLPAKNRKGFLIKRIPMKVKDRIT--RVE 216
P07832 144 NTTITSFRLNdLNGADKGGLVPFCQDIIDSLDKPEMIFFTVK-----NIKKKLPAKNRKGFLIKRIPMKVKDRIT--RVE 216 Influenza B virus (B/...
Q6I7C3 147 QLTVDAIKET-EGPFKGTTMLEYCNKMIEMLDWKEVKFRKVK-----TMVRREKDKRSGKEIKTKVPVMGIDSIK--HDE 218 Influenza C virus (C/...
O41353 140 EETVEFLEQN-LRRKIGPTLLSYCQAIADVMELDETTYEGARdprpwDIQLEEIDSDEEDPLFRQVGREETYTIKfsREE 218 Thogoto virus (isolat...
P03431 144 ANTIEVFRSNgLTANESGRLIDFLKDVMESMKKEEMGITTHF-----QRKRRVRDNMTKKMITQRTIGKKKQRLN--KRS 216 Influenza A virus (A/...
6QWL_K 217 YIKRALSLNTMTKDAERGKLKRRAIATAGIQIRGFVLVVENLAKNICENLEQSGLPVGGNEKKAKLSNAVAKMLSNCPPG 296
P07832 217 YIKRALSLNTMTKDAERGKLKRRAIATAGIQIRGFVLVVENLAKNICENLEQSGLPVGGNEKKAKLSNAVAKMLSNCPPG 296 Influenza B virus (B/...
Q6I7C3 219 FLIRALTINTMAKDGERGKLQRRAIATPGMIVRPFSKIVETVAQKICEKLKESGLPVGGNEKKAKLKTTVTSLNARMNSD 298 Influenza C virus (C/...
O41353 219 LWDQMRTLNTMCKHLERGRLNRRTIATPSMLIRGFVKIVEDAAKEILENVPTSGVPVGGEEKLAKLAS------KQTFHT 292 Thogoto virus (isolat...
P03431 217 YLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDT 296 Influenza A virus (A/...
6QWL_K 297 GISMTVTGDNTKWNECLNPRIFLAMTERITRD--SPIWFRDFCSIAPVLFSNKIARLGKGFMITSKTKRLKA---QIPCP 371
P07832 297 GISMTVTGDNTKWNECLNPRIFLAMTERITRD--SPIWFRDFCSIAPVLFSNKIARLGKGFMITSKTKRLKA---QIPCP 371 Influenza B virus (B/...
Q6I7C3 299 QFAVNITGDNSKWNECQQPEAYLALLAYITKD--SSDLMKDLCSVAPVLFCNKFVKLGQGIRLSNKRKTKEV---IIKAE 373 Influenza C virus (C/...
O41353 293 AVTGELSGDQEKFNECLDPDAMRLMWTVFLRKlgCPDWIMELFNIPFMVFKSKLADMGEGLVYTKGKLTDRKplgEMPSE 372 Thogoto virus (isolat...
P03431 297 ELSFTITGDNTKWNENQNPRMFLAMITYMTRN--QPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRT---QIPAE 371 Influenza A virus (A/...
6QWL_K 372 dlfsiPLERYNEETRAKLKKL-KPFf--NEEGTASLSPGMMMGMFNMLSTVLGVAAL--GIKNIGNKEYLWDGLQSSDDF 446
P07832 372 dlfniPLERYNEETRAKLKKL-KPFf--NEEGTASLSPGMMMGMFNMLSTVLGVAAL--GIKNIGNKEYLWDGLQSSDDF 446 Influenza B virus (B/...
Q6I7C3 374 -----KMGKYKNLMREEYKNLfEPLekyIQKDVCFLPGGMLMGMFNMLSTVLGVSTLcyMDEELKAKGCFWTGLQSSDDF 448 Influenza C virus (C/...
O41353 373 ---------FDDLVRNVVGN------------SISCRLGMFMGMYNLTSTLLALISI--EREELTGSH-----VESSDDF 424 Thogoto virus (isolat...
P03431 372 mlasiDLKYFNDSTRKKIEKI-RPL---LIEGTASLSPGMMMGMFNMLSTVLGVSILnlGQKRYTKTTYWWDGLQSSDDF 447 Influenza A virus (A/...
6QWL_K 447 ALFVNAKDEETCMEGINDFYRTCKLLGINMSKKKS-YCNETGMFEFTSMFYRDGFVSNFAMEIPSFGVAGVNESADMAIG 525
P07832 447 ALFVNAKDEETCMEGINDFYRTCKLLGINMSKKKS-YCNETGMFEFTSMFYRDGFVSNFAMELPSFGVAGVNESADMAIG 525 Influenza B virus (B/...
Q6I7C3 449 VLFAVASNWSNIHWTIRRFNAVCKLIGINMSLEKS-YGSLPELFEFTSMFFDGEFVSNLAMELPAFTTAGVNEGVDFTAA 527 Influenza C virus (C/...
O41353 425 IHFFNCKTHEEMFKQAETLRLTLKLVGINMSPSKCiLISPAGIGEFNSKFHHRDFVGNVATELPALVPNGTNPMTDLAMG 504 Thogoto virus (isolat...
P03431 448 ALIVNAPNHEGIQAGVDRFYRTCKLLGINMSKKKS-YINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIG 526 Influenza A virus (A/...
6QWL_K 526 MTIIKNNMINNGMGPATAQTAIQLFIADYRYTYKCHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNIYNLRNLHI 605
P07832 526 MTIIKNNMINNGMGPATAQTAIQLFIADYRYTYKCHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNLYNLRNLHI 605 Influenza B virus (B/...
Q6I7C3 528 MSIIKTNMINNSLSPSTALMALRICLQEFRATYRVHPWDSRVKGGRMKIINEFIKTIENKDGLLIADGGKLMNNISTLHI 607 Influenza C virus (C/...
O41353 505 LNVIKHSVNTGQMNLCTGALAMRIFNHAYKYAYM-----ALGVTRRTRFMEE-----NAITPLLTNQGASPVHSFSTMHL 574 Thogoto virus (isolat...
P03431 527 VTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFEIKKLWEQTRSKAGLLVSDGGPNLYNIRNLHI 606 Influenza A virus (A/...
6QWL_K 606 PEIVLK--YNLMDPEYKGRLLHPQNPFVGHLsiegiKEADITPAHGPV-KKMDYDAVSGTHSWRTKRNRSILNTDQRNMI 682
P07832 606 PEIILK--YNIMDPEYKGRLLHPQNPFVGHLsiegiKEADITPAHGPI-KKMDYDAVSGTHSWRTKRNRSILNTDQRNMI 682 Influenza B virus (B/...
Q6I7C3 608 PEEVLK--FEKMDEQYRNRVFNPKNPFTNFD-----KTIDIFRAHGPI-RVEENEAVVSTHSFRTRANRTLLNTDMRAMM 679 Influenza C virus (C/...
O41353 575 DEVALRrhLGLLDEETLRRILNPNNPVTQKG-----DPSMFFRIENKMpQIMEDYSVPSCFKYTLSRNRTIQDKPHKALL 649 Thogoto virus (isolat...
P03431 607 PEVCLK--WELMDEDYQGRLCNPLNPFVSHKeiesmNNAVMMPAHGPA-KNMEYDAVATTHSWIPKRNRSILNTSQRGVL 683 Influenza A virus (A/...
6QWL_K 683 LEEQCYAKCCNLFEACFNSASYRKPVGQHSMLEAMAHRLR---MDARLDYESGRMSKDDFE 740
P07832 683 LEEQCYAKCCNLFEACFNSASYRKPVGQHSMLEAMAHRLR---MDARLDYESGRMSKEDFE 740 Influenza B virus (B/Lee/1940)
Q6I7C3 680 AEEKRYQMVCDMFKSVFESADINPPIGAMSIGEAIEEKLL---ERAKMKRDIGAIEDSEYE 737 Influenza C virus (C/Ann Arbor/1/50)
O41353 650 NKEERYQRVTSIINKLFPEVLIQEASAPGTVRESLKRRLElvvERSDLD--------EERK 702 Thogoto virus (isolate SiAr 126)
P03431 684 EDEQMYQRCCNLFEKFFPSSSYRRPVGISSMVEAMVSRAR---IDARIDFESGRIKKEEFT 741 Influenza A virus (A/Puerto Rico/8/1934(...
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