Conserved Protein Domain Family
ProSAAS

?
pfam07259: ProSAAS 
ProSAAS precursor
This family consists of several mammalian proSAAS precursor proteins. ProSAAS mRNA is expressed primarily in brain and other neuroendocrine tissues (pituitary, adrenal, pancreas); within brain, the mRNA is broadly distributed among neurons. ProSAAS is thought to be an endogenous inhibitor of prohormone convertase 1 may function as a neuropeptide. N-terminal fragments of proSAAS in intracellular Pick Bodies (PBs) may cause a functional disturbance of neurons in Pick's disease.
Statistics
?
PSSM-Id: 462126
Aligned: 11 rows
Threshold Bit Score: 95.8307
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_013989722  33 AKPLSAARGVEGRGl-DATGGGVRRLRRDLRDSLPYEAGM-TAYPGesadvlTRRGDNKLLYKP----EEWRGQGLGQ-- 104
XP_013881602  17 AQTLPAAREGGRGQ--DVSVGGVRRQRRELGEQLPYEDQV-MSYSSl----qPGGGANDLYYQS----EDWRGRGIDT-- 83 
XP_014037316  32 AKSLSAAPGVGGRGl-DATGGGVRRLRRDLRDSLPYEAGM-MSYPGesadvlTRRGGNELLYQP----EEWRGQGLSH-- 103
OCT66848      22 AKPLGSVP--------RDDVGMSHRFRRSLPAGIPYDTDM-MSYLP------SESLQEEASYPDinpaLLSRLATYPQeq 86 
OCT65150      81 AKPLGSVA--------HDNDGMSHRFRRSLPAGIPFDTDM-MSYLP------AESLQEEPLYPDinpaLLSRLAAYPQde 145
XP_007529458  34 ARPVKEARSLGAPSppVVEASGARRFRRALPRAE-AAGAVq---------------------------------eLAR-- 77 
1_pfamImport   1 TRPVKEPRGLGAPSppMAETGASRRFRRAVPGGE-AAGAVq---------------------------------eLAR-- 44 
XP_003462608  34 ARPIKDPRSLSAASpaIAEAGSQRRFRRAAPRGEAAAGAVq---------------------------------eLAR-- 78 
XP_004396898  34 ARPVKSARP-GSAGlgVRVCGARLAATPCPPLAP-GAGPAs---------------------------------pRRS-- 76 
NP_001159601  25 AKPLSAMRGGVRS------YDVPVRLRRELRDSVPYEAQM-ISYPSa----dFKSRSND-YYPS----EVLRAQGLGQ-- 86 
XP_015198338   1 -------------------------MRRELRDSLPYEAQMvMSYPPpgaglgSEGRNNEIFYQPgtglEGWKGRGVGE-- 53  spotted gar
XP_013989722 105 ---------------------ALQQLVENDQRR---------EQE----TAYLAGLLRLLSEA-D---------VQEGGE 140
XP_013881602  84 ---------------------ALQRLVEREERR---------EQReeqrAAYLAALLRLLSEA-EstglvgpadVEVVEE 132
XP_014037316 104 ---------------------AVQQLVENDERH---------EQD----AAYLAGLLRLLSEA-Egt------aGEDGGV 142
OCT66848      87 llaamekfglnhraealqdsiALQQLAEEGQRR---------DKE----AMYLANLLHLWNQIsQsrgypeqlqALR--- 150
OCT65150     146 llaalekfgsnhrtdplqdsrALQQLAQEGQWR---------DKE----AKYLANLMHLWNQIsQgrgypeqlaALRGSI 212
XP_007529458  78 ---------------------ALAHLLEAERQErar---aeaQEAedqqARVLAQLLRSWGAP----------------- 116
1_pfamImport  45 ---------------------ALAHLLEAERQErar---aeaQQAedqqARILAQLLRLWGSP----------------- 83 
XP_003462608  79 ---------------------ALAHLLEAERQErar---aeaQEAedqqARVLAQLLRVWGSP----------------- 117
XP_004396898  77 ---------------------PVALSTGLARMKeggartglcPRGddwgAPVRPQLLRAWSTP----------------- 118
NP_001159601  87 ---------------------ALQRLVESDQRR---------EQE----AAYLASMLRLLNEA-Qgt-----gqGRAGDQ 126
XP_015198338  54 ---------------------ALQQLVDDDRRR---------DQE----AIYLAGLLRLLSES-Ygapqk---------- 88  spotted gar
XP_013989722 141 EIq----gPGDFQAPYPpDYDETEQGMRMRMPQTAapwqgllDPQLTQALLNRyrqerlq---------qqqaglpGLPT 207
XP_013881602 133 EDeedqepPQDFQGPAGvDYDETGRGMSMGRPSAArwg--lvEPQMAQVLLDR-----------------------LDPR 187
XP_014037316 143 EDq----gPADFQGHYTrDYDETEQGMRMGKPQAAapwqgllDPQLTQALLNRyrqerlq----------qqaglpGLPA 208
OCT66848     151 ---------RELPRSYQ-DYDDTGLASRSIRAQLP-------RNQLAQATQSHyrqdgg--------------------- 192
OCT65150     213 QR------NGQFTRSYQ-DYDDTSLAPRSIRPKVP-------RNQMSEAAQSRywqdgg--------------------- 257
XP_007529458 117 ------------------RTPEPPPAL-DDDPDAP-------AAQLARALL-Rarldpaalaaq-llpaqapaplrPRPP 168
1_pfamImport  84 ------------------RPSDLSLGQ-DDDPDAP-------ATQLARALL-Ltrldpaalaaq--llpvpasvlrTRPS 134
XP_003462608 118 ------------------RASDAPLGL-DDDPDAP-------AAQLARALL-RarldpaalaaqlvpapvpaaahrPRPP 170
XP_004396898 119 ------------------RTNDPALGL-EDDPDAP-------AAQLARALL-RarldpaalaaqlvpgpapaaalrPRPP 171
NP_001159601 127 EEe-----GGDFQGPYPpDYDETEQAVSMAKPQASwqg--llDPQLTQALLNRykqer--------------lvqaGLAP 185
XP_015198338  89 ---lgleeTGDFQGPYPpDYDETEQGLSMDKPQAAwqg--llDPQLTQALLNRyrqer--------------lrqaSLPP 149 spotted gar
XP_013989722 208 AINRL--ANSRLETGSQDR---DEEAL--RYLV--AKVLSNISPTKPQgssgrrarrdl-vsasgdggrvRASSSPVLHR 277
XP_013881602 188 LVQSLlqRARQVGRAPSEP---TRDQDtlRRMI--TKVLSSIGPNEAQpirtrr----------dlsvkaADSGSSAHRR 252
XP_014037316 209 TINRL--TDDRLETGSQDR---DQEAL--RYLV--TKILSSIGPNNPQgssgrrarrdlvsvsggggggvRAASEPVFHR 279
OCT66848     193 --ykatgPHQQQEEVSEDGipmDEGML--RFLV--TRVLSAMSEAEMP----------------------QRLSTPPSRR 244
OCT65150     258 --yqatgPHMQQEEVNNDGilmDEEML--RFLV--TQVLSAMSEAEMP----------------------QRLSSTPPRR 309
XP_007529458 169 VYDDGppAGPEPEDAGDETsdvDPELL--RYLL--GRILAGNSE--------------------------PEPAAA-PRR 217
1_pfamImport 135 AYDDRp-TGQGAEDAGDWTpdvDPELL--RYVRagGGSFTGSPD--------------------------PETWALCVLV 185
XP_003462608 171 VYDDGp-TGSDAEETGDETpdvDPELL--RYLL--GRILTGSAE--------------------------PEAGTT-PRR 218
XP_004396898 172 VYDDGp-TGPEAEDAGDETpdvDPELL--RYLL--GRILAGSAD--------------------------PEAVAV-PRR 219
NP_001159601 186 AANRI--PERE-----QDK---DQEML--RYLV--EKILSSLASGGNQgsssnprak----rdlsavssiERPIKPALKR 247
XP_015198338 150 TSRLLtaDSRSGGPGGEEG---EEEVL--RYLV--GRVLSSLASETPQqtpsrla--------krdlaaaGDRPTPPLKR 214 spotted gar
XP_013989722 278 SRRSLDSP-PSPSLNREHSvgLLRVKRLgdmegmvvegpcgpgeeveghrtpdhmvELQRMKKIDN----ELqpQPggrp 352
XP_013881602 253 TRRSLDDTsAPPSPNNQPS--LLRVKRLedeeeeee-------------klrpqvtALQRMKRIDTmataDAaeLNhgsr 317
XP_014037316 280 SRRSLVSP-PTPSPSREPSpgLLRVKRLgymeegpgwlgg----ereghktqnhavGLQRMKRIDT----ELqaQPggrp 350
OCT66848     245 LRRSLPENpPGTASSN-----LLRIKRIddlldp-----------------dyvanGLLRRKRIDG----DLeaRP---- 294
OCT65150     310 LRRSLSENpPGDAPSD-----LLRIKRIeslpdp-----------------dyvtnGLLRRKQIDG----DLevRP---- 359
XP_007529458 218 LRRAADQNpTPDVLPEGVLgaLLRVKRL---------------------------------------------------- 245
1_pfamImport 186 VRQTRS---GPDVPLKRAGgaA-AVKRL---------------------------------------------------- 209
XP_003462608 219 LRRSANQDlAPDVPPEGVLgaLLRVKRL---------------------------------------------------- 246
XP_004396898 220 LRRAADQDlGPEVPPEGVLgaLLRVKRL---------------------------------------------------- 247
NP_001159601 248 SRRSLDSA---PGPQAEAS--LLRVKRLdddddvdedav-------agqsngtphiGLQRMKRIDT----DL--PPpkkh 309
XP_015198338 215 PRRSLDDG-APPSPRVEPS--LLRVKRLgdeeeeeeee--------raaaaggaraGLQRMKRIDS----EL--QGggrp 277 spotted gar
XP_013989722 353 srrr--ralnydpITYDPELLVQHILHY 378
XP_013881602 318 rr------rrraaPTFDPQVLMDQILEY 339
XP_014037316 351 srrrralnydpqaLTHDPELLVQHILHY 378
OCT66848     295 -------------GHY-----TDQLLKY 304
OCT65150     360 -------------GPYVEQRVTEQLLKY 374
XP_007529458 246 -------------ETPAPQAPARRLLPP 260
1_pfamImport 210 -------------ESPPPQAPMRRLLRP 224
XP_003462608 247 -------------ENPPPPAPARRLLPP 261
XP_004396898 248 -------------ETPSPQAPVRRLLPP 262
NP_001159601 310 s-------rkrraLSYDPALIAQHILQY 330
XP_015198338 278 a-------rkrraVTYDPDLLAQRILQY 298 spotted gar
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap