Conserved Protein Domain Family
CCDC22

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pfam05667: CCDC22 
Coiled-coil domain-containing protein 22
Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.
Statistics
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PSSM-Id: 461708
Aligned: 30 rows
Threshold Bit Score: 394.779
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001031750   31 MEDTDQLLFASLQQFGFNLgNKKITSLFDV----------DGDILRSICFQFLE-FMGSKVtiNSM-----------KGQ 88  
XP_004995815    1 MDEVDKIILLTLRQLGTDV-EEDVASLADL----------PTKAFVEGAARCIN-TINGND--EMPlsl------pgSMA 60  
EDQ91553      453 MEEVDRIILLNLKHLGTEI-PETVQTVSDL----------GTDVFVEGCARCLN-VINQSD--EMPlkl------psTMA 512 
Q01GI4          3 AADADEVLFHALRSSGIDV-HPSWSAIDDVvndvddessaNTNALLNIVRQCLC-LIDATAyeSLPrgfplddgsgtSVA 80   Ostreococcus ...
XP_002902835    1 MAEADAFISAALQQSGWLE-ADASWSVADL----------SSDALIVLVLKFLArLQDADNgvNFSlscte-akapvGVA 68  
Q54MP2          1 MDEADGIILITLKDLGCEI-EENE-TIKNF----------DSEMVYKCILAYLR-VINEQKviNLTntl------pkNMS 61   Dictyostelium...
EFA84683      358 MDEADGIILLTLRDLGCEL-GDEI-TIKDF----------DAEIVYKACLAYLR-VINEAKvaNLTati------pkNMS 418 
5_pfamImport    1 MEEVDQIIIGSLLNIGCEF-AEGMTSLKQF----------TTENVVEATVKCLR-IINPDY--KMShif------ppGMS 60  
XP_011270107    1 MEEVDNIIIVSLRSIGCDI-PDDVASIKAF----------STDIVVDGAATALA-TINEKY--KFPrrl------pnEMS 60  
XP_026693321    1 MEEVDQIIIGSLLNIGCEF-AEGLESLKQF----------TTDNVVEGTVKCLR-IINPDY--KMShif------ppGMS 60   vase tunicate
XP_001031750   89 QKFRQSTQISEELKNL---CNLRIDINSLLSPSKDDLRKIVVAILQKIsmheegdnPRLNISQR---------GgAQAFD 156 
XP_004995815   61 ARFRVGTTLATACQDLg--YGSNIGYNTFLYSNEDDCRQLLMWLIERL--------PKETTSTTgae----tlG-QEAML 125 
EDQ91553      513 ARFQVGTTLAKACQALg--YTSSIGYNTFLYGNENDCRNILMWLIERL--------PQDVSDATqas----agTtGLARF 578 
Q01GI4         81 ERFRVAGRYASALIEVggeQRDGDGFQQFLYPSASSARAMLKRLLELL--------PRRDVDEAvreaekarvSaASARL 152  Ostreococcus ...
XP_002902835   69 ARHRVGSQLANILKELg--YAGDCGYNHFLYPSEKETRNILSWLVGKL--------PRSKHEENed-----evS-KSEVL 132 
Q54MP2         62 ARVNACSLIANIIKDSg--YRSELSYHNLLYPNVNDIRKIFIFLGQLL--------PKKEVESG---------GvSIQKL 122  Dictyostelium...
EFA84683      419 ARVNSCSVLAATIRETg--YRAELSYHNLLYPNINDVRRIFVFLGQHL--------PKKEVVEG---------D-STASL 478 
5_pfamImport   61 ARFRVGTSIANTCKSIg--YQGDIGYQTFLYSAERDVRQIFMFLVEKL--------PRKEGVKEdtv---qtvA-ESNVL 126 
XP_011270107   61 ARFRICTNMANACKELg--YADDIGYHQFLYSNESEVRKLFMWLVEKL--------PRESSDATae-----ptG-VSAVL 124 
XP_026693321   61 ARFRVGTSIANACKEAg--YRGDVGYQTFLYSAERDVRQIFMFLVEKL--------PRKEGVKEd-------iE-SASVL 122  vase tunicate
XP_001031750  157 syedkIRYLQEQRRKEILKNWVNEEW-------------------------IHPALGNNKFNQFRMYdne---------- 201 
XP_004995815  126 -----QRAITAEIDKQLSCPWIPPAFhrdglc-------------wsnnrtAWHLISRRGVRSFRSTtlftsemda-ant 186 
EDQ91553      579 -----RAAVAADVRRRIELPFLPHAIyrdgai--------------aldakTTLQMNPRAQRPFRTNtleia-------- 631 
Q01GI4        153 g---sRARAMVARSTKAEAAW------------------------------------GRAAGALKGFagvaaaara-kkr 192  Ostreococcus ...
XP_002902835  133 asmgaNSSIAEAAASVLASDRLANIFsswkrek------------tlhmlpNQNVQGLRGFQRLPLQtsplelpwsrpgk 200 
Q54MP2        123 -----EDQICQYLQGCVKESWIPYFCp-----------------------fSKRIPGNYSTATLFTTtggnlripsrgrq 174  Dictyostelium...
EFA84683      479 -----KDLICNHLASSIKESWMPYFCp-----------------------fTKRIPGNYSTAKLFTVaplkipar--grq 528 
5_pfamImport  127 -----QRRIGQVLREKCSTMWMPFYCk-----------------------------pLIEGVPFRTQplfipkys---kg 169 
XP_011270107  125 -----NKAITDELEYRAEAPWTLPVAkrsgyarrvatipgptpkspptyvpHQQWEGLRGVHRLHASvvvipagag-dvt 198 
XP_026693321  123 -----QRRIGQVLREKCAVLWMPFYCh-----------------------------tSPKKIPFRTQpiniskys---qg 165  vase tunicate
XP_001031750  202 --lvlDSNSLSNKliidiin----------gkmkqnLYAslakiiENRALKAQIDEMEVYADVQKIseQRHqLQIEEIKK 269 
XP_004995815  187 araayETTnqqtipqqr----------svatsslasILA------RNSRLLASERAREEELTAAGRdpA---LPNEDFVR 247 
EDQ91553      632 dsngsQERVAYETehmplvtaqp----mrsanrltsLLA------KHAALQARRAVWQEEWSTLGM---TSgKTEQQYRH 698 
Q01GI4        193 tddttNAREFYTSrlttsssggffgnlsadtyavpsVLE-----------YAARVRAEEEAEEDARrlKFSgVVRAEFIG 261  Ostreococcus ...
XP_002902835  201 sth------------------nlfekfssdsikatsLLEalavakRGSTMFLREDEFDDDVEEDNV--------DAQLKQ 254 
Q54MP2        175 lkvtpGLEQYYSQylepltlqt-----nrfediapsVFE------YNLSIYAEAQERDNEWNDKGV--SSG-MNPIDYRK 240  Dictyostelium...
EFA84683      529 lkltpGLEDFYIKhlrpinqqp-----nrtddvapsVFE------YNLSIYAEAQERENEWNTKGS--QSG-LNPLEYKK 594 
5_pfamImport  170 hrnskT-------------------------------------------------------------------------- 175 
XP_011270107  199 kplskELRKYYAGalpyltaqp-----pvrqdvapsILE------KVSAEYTAAREWEEIWNKEGM--DTG-LSEAEFRD 264 
XP_026693321  166 yknskS----QDEttydfvhrqi----knrdqltpsLLE------LNSKQTVSVTSLDKAS----------------GQD 215  vase tunicate
XP_001031750  270 QVatevtkaSKKKVNRIAEQFTEQPQQTEEevkqqlneEKQTIFNLEMQFqeeqtvhnpvldpqnDEKNERSLnkSNAET 349 
XP_004995815  248 QK-------RTTTRRTISAKVKAALFNDAk--------QEVDMAKFLAKF--------------------SGIelGKMSM 292 
EDQ91553      699 DK-------QDSILKNMRQQLQKGIAADMTah-----rQRQDIRTFLDGF--------------------ANVqlGKKSL 746 
Q01GI4        262 PDgkpfdlrKRGGLRGLVAEIFRLALEGGFytepraiqACAELEE---------------------------------TQ 308  Ostreococcus ...
XP_002902835  255 GQ-------VEGLLTDATRAGESGFLSPQEaeaeddefATIEPQTFLSSAlpdvp-----lslnnPSSGTTDTmaTEGAT 322 
Q54MP2        241 NK-------QKQVLSKMNDSIRQSIIDGGNnqissncnSGDSFLDIISEF--------------------RGNslDVGGQ 293  Dictyostelium...
EFA84683      595 NK-------SKTILSKMNDSIRSAMVDGSsad----srRNNTFDHVIGQF---------------GMGSADDD----YGQ 644 
5_pfamImport  176 ----------------------------NIlsfl-qlpDAIPFDSSLDEV---------------IQIVTGQSlkTNRSR 211 
XP_011270107  265 RK-------RQFVRSKMAEYVRSSALKGDGagf--grnDADSFASFLDSF---------------SDRGLRN---AKGSR 317 
XP_026693321  216 SK-------RRKVQKEAFQWKHKSMi-----------tDKIPLDSSFDDV---------------IQAVTGNSgnIKQSR 262  vase tunicate
XP_001031750  350 LNSSNALlnssnSLlnsanNNSst-------------------------tqASKpmtsaa-------------------- 384 
XP_004995815  293 FRAKHKL-----QF-----AKE-----------------------------DE--------------------------- 306 
EDQ91553      747 FRKREEL-----QF-----QSE-----------------------------A---------------------------- 759 
Q01GI4        309 VVDEDKVvesanDV-----ENA---------------------------------------------------------- 325  Ostreococcus ...
XP_002902835  323 TDSTGSAsigasQFavlqtANDn--------------------------------------------------------- 345 
Q54MP2        294 FNRKKAF------------TNEl----------------------------NNNnnnnn--------------------- 312  Dictyostelium...
EFA84683      645 FARKKAF------------TNE-----------------------------EVA-------------------------- 657 
5_pfamImport  212 FAHAKDL-----QF-----TTVsddgcinyschkplqirpvipqkpshlakLENkevfylssldwgsdyfrtgfidgehl 281 
XP_011270107  318 FTHAEKF-----QF-----TQD-----------------------------E---------------------------- 330 
XP_026693321  263 FAHAKSL-----QF-----TTEeqks----------------------frlRPTv------------------------- 285  vase tunicate
XP_001031750  385 --------------nnsrlsLG----------------------------------------KSNLnIGINIDELktnnS 410 
XP_004995815  307 ---------------------A----------------------------------------AVAAtKTVTDEELkqqrE 325 
EDQ91553      760 --------------------------------------------------------------S-DApKAATQEELeqqrQ 776 
Q01GI4        326 -------------------------------------------------------------------AMDTLEDRikarE 338  Ostreococcus ...
XP_002902835  346 ------------------------------------------------------------------------------eE 347 
Q54MP2        313 ----------------dsttNT----------------------------------------NKVEtEIETEEQRqlkrQ 336  Dictyostelium...
EFA84683      658 --------------------SE----------------------------------------PIEPkAKETEEERqqkqQ 677 
5_pfamImport  282 tpptkdrtqddptssvdeasSS----------------------------------------ADVAkDQEELEEIrfqrE 321 
XP_011270107  331 --------------------------------------------------------------GAAAaVADTEEELrkrrE 348 
XP_026693321  286 -------------------pQKpshlikhenkkkddaetdnqessedgvdgssagggedaviP------EEPEEVkfkrE 340  vase tunicate
XP_001031750  411 KEISTLSQKYEELQNKKQKYAKEREKMETNIQQKTEEAEVLKEQNKQTKKDIENMEMLIKEL--E---TKGGSSELKKEI 485 
XP_004995815  326 DELSALQGEVEDLESSLQAMRDNLASLQSTAEALAEQTARMQEENEALTKEQKVRKRVLDLLp-N---AEENMQLLKDKI 401 
EDQ91553      777 AELEELETRLSDLMATMQSLQGELSTFDKDAVKMDSKLAELKALAEELAANNAVRKRVLDLLp-N---ADENIERLGQAI 852 
Q01GI4        339 RDLEDVHRRIDEAMSVVSTVDDEIAACASKVKEAMEATDAKRALTAELESNYLLHKQAVGMVlaTdrpVEESEAELNKVL 418  Ostreococcus ...
XP_002902835  348 QSLDEVQKQVDDTERRIAAMRKVLDRERGHLQQVEQHVLETQSTGQELQKQLARQKQLLAMLp-Q---AQANILKLEAIC 423 
Q54MP2        337 AEIDALQSQIDEISESIQLHNKEMLDFLSLMRQSESENLEQDQQREVLEKQYKIKKKTFSLLd-D---AEGNMKELQSLC 412  Dictyostelium...
EFA84683      678 EEIDQLQSVLEELANRMANATSEMDDWIQQIRQLEAQINEEDRKRAELEKEYKVKKKTFGLLe-N---AEENFAKLQELC 753 
5_pfamImport  322 ED--EMNKMISDVVEDEEKYKEDLKMVEMSMKQIVVNTQELESTNEERIKQVKLKEKTLKLLp-N---AEENMEKLKAMV 395 
XP_011270107  349 EELRALQERLDALSAEVDRMEHEIRNFNVNTSQLESNLREEKSASATKEALYRSKVKVFELLp-E---ADKNIELLQGLV 424 
XP_026693321  341 EE--EIKVKILDADAGEEKYKEELKMVELSIKQLMIKTEELETNNEEEVKNVKLKEKTLKLLp-N---AEENMEKLKSLV 414  vase tunicate
XP_001031750  486 KELEQDIQQIEIEWKEYQETDIKKLEELKDELTKKKEKRELIKDKIKRIDTELQQVIQDLQMAYEKKVQL---------- 555 
XP_004995815  402 DEVAAKLAALAERWEEHRVALIKEYRDLKVAAANKNSEARKQAESIQELRSQAKQIIADAKQKEQLFQQL---------- 471 
EDQ91553      853 DALARKLIAIGEKWEPHRRELLREYQQLKSAAADQMSEIKVQMAYVQEMRETTQGILAGAKAKEQRVAEL---------- 922 
Q01GI4        419 VAAKERLEQLSAEWNAAKTPLLAAIEAHAEGAREKRKKAKNQLEEIEKWRSEGKDTSSLLRIKEQEQRQL---------- 488  Ostreococcus ...
XP_002902835  424 QSNAEKKVEISQQMGSARGPLLLEYAALEGQKSSRKARCRQLIREMKAFRAEMLEISGIIQSKMESLKALervqerqlak 503 
Q54MP2        413 NQTSSNLLEMSGEWEKVRKPIIEKYRSLKDKQNNQADETKSKLDRIKEMRILIKKLVSEVQQKDDQFQQL---------- 482  Dictyostelium...
EFA84683      754 QQTSASLIEMSGEWEKVRRPIIEKYRQLKDEKANQSDEAKSKVERIKEIRALIKKMIADIRAKEELFTQL---------- 823 
5_pfamImport  396 DASSQRLVELGKLWEEKRIPLVAEIRRLKQSKTETEFDAERKVEEIRLLRSRMKDVSEETKQKDQLIKQL---------- 465 
XP_011270107  425 STSTKRLVELATKWEAVRAPLVLEYRTLKESQDGRMTESRRKLAQIKEFRESMKQIAEEARIKDELYRQL---------- 494 
XP_026693321  415 DASSKRLVELGRLWEEKRVPLIEDIRRLKQSKTESEFDAERKVEEIRMLRTRMKDVAEETKLKDQLTKQL---------- 484  vase tunicate
XP_001031750  556 VEDYKRMPQGGNRQEYIKKIMEIKKNYDKQRGDIQKIIQDVKSVEESIQYYQGTLERHMNELEAIYNTDAKK--NESLSK 633 
XP_004995815  472 VQDYERMNKDILRSSYTSRILEIVKSIDKQKREIQKILVETRGLQKDLGLLEGKIERTFTVAEEEIFKESKA--NPAARL 549 
EDQ91553      923 QAEYEKRNNATQRSWYVERILEIIKSINKQSADIETSILDIRAMQREINQISDRLSRQFTVVDEMVFKDAKK--DADIKR 1000
Q01GI4        489 LDQYEAAPKSVHRPSFVRRVNEIIKNIKKQEREIVKIVGDTRSVQSDINSAQACLERTYTVVEEILFREARS--DELCRA 566  Ostreococcus ...
XP_002902835  504 LGQKKDADGPMTRNMYTSRIMDIIKQVHKQKQDIAKILDDIKGLQKQLNTASERLKRTEAVAEDKLYSAASTskSTSSTK 583 
Q54MP2        483 QDQYKQAPKDSNRSQYTRRILETVKNIKKQKVDIDKVLLDTKNLQKEINTITDTAVRTFELVKDLLYNDAKK--DQTAKQ 560  Dictyostelium...
EFA84683      824 QDTYKAMPKDTNRSMYTRRIIESVKNIKKQKEDIDRILLDTRTLQKEINTITDTAVRTFDAVKDMLYADAKK--DQTAKT 901 
5_pfamImport  466 KTELDSVKRDISRQSYTRRILEIVASIHKQKQEIQRVIEDVKLVQKTMNKLKGRANRTFSAADEVIFRDAKQ--DEGSKQ 543 
XP_011270107  495 TAEYEKMTKDINRSIYTRRILEIVKNIKKQREDIDKVLIETRALQKEINHTSDVLNRTFSATDELIFKDAKK--DDACRR 572 
XP_026693321  485 KAELESVKRDISRQSYTRRILEIVASIHKQKQEIQRVIQDVKQVQKTMNRLKGRAERTFSAADEVIFKDAKH--DEGSKQ 562  vase tunicate
XP_001031750  634 --QifkiYQEYRTI---FDQTVNNLREVGNKMIESRSIEAKTVLLATK 676 
XP_004995815  550 --A----YKHLANLhaeCGRLIDVVKSTGTVAREIRDLEDQIEVEQRK 591 
EDQ91553     1001 --A----YQLLASLhtgCEDLIQCVENIGSLEKECRELDNAVHVEQAK 1042
Q01GI4        567 --A----YKHLHGMhagFADLIDKVEATGVARRSQTDLQRKLVEISKQ 608  Ostreococcus tauri
XP_002902835  584 adAyvecYRKFAQVrelFEELIVVVGDVGKKENAARDLQNWISQLESR 631 
Q54MP2        561 --A----IKSFAIIddkFQKLFKTIDETGNFQNNILNLNSKIEHVSQK 602  Dictyostelium discoideum
EFA84683      902 --A----IKSFAVIdekFQTLLTAIDETGTYQNNIFTLTSKIDYISQK 943 
5_pfamImport  544 --A----YKYLVSLhdnCAALLKTVEETGLIMREIRDLEGQIDIEIGK 585 
XP_011270107  573 --A----YKYLASLhehCNVLIADVENTGKLLNEIRDFEEKLEQLNQQ 614 
XP_026693321  563 --A----YKYLVSLhdnCATLLKTVEETGLIMREIRDFEGQIDIETGK 604  vase tunicate
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