5T6Q,6C94


Conserved Protein Domain Family
CYP4

?
cd20628: CYP4 
Click on image for an interactive view with Cn3D
cytochrome P450 family 4
Cytochrome P450 family 4 (CYP4) proteins catalyze the omega-hydroxylation of the terminal carbon of fatty acids, including essential signaling molecules such as eicosanoids, prostaglandins and leukotrienes, and they are important for chemical defense. There are seven vertebrate family 4 subfamilies: CYP4A, CYP4B, CYP4F, CYP4T, CYP4V, CYP4X, and CYP4Z; three (CYP4X, CYP4A, CYP4Z) are specific to mammals. CYP4 enzymes metabolize fatty acids off various length, level of saturation, and branching. Specific subfamilies show preferences for the length of fatty acids; CYP4B, CYP4A and CYP4V, and CYP4F preferentially metabolize short (C7-C10), medium (C10-C16), and long to very long (C18-C26) fatty acid chains, respectively. CYP4 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
?
PSSM-Id: 410721
Aligned: 93 rows
Threshold Bit Score: 433.873
Created: 20-Sep-2017
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
 
heme bindingchemical
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Structure:5T6Q: Oryctolagus cuniculus CYP4B1 binds heme; contacts at 4A

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                        #                 ##       #   #      #         
5T6Q_A        56 PYAHPLWvgqfiGFLNIYePDYAKAVYSRGDPKapdvyd--fflqwiGKGLLVLDGPK-WFQHRKLLTPGFHYdvlkpYV 132 rabbit
XP_022205802  71 SGPIRFWfl-neLIVFVAkPQDAEILLSNMKHLrkpwqyk-llkpfmGEGLFTNSDNSiWRLHRKMITPAFHFsilkgFL 148 brown planthopper
XP_022192967  79 GEPCRIWll-neLCVILTkPKDIEVVLGNVKIFkksghya-mmkrlmGQGLFTADDFAvWRRHRKIITPTLHFnilkdFV 156 brown planthopper
XP_021918791  87 GSIFKLWig-qdLFVLLSnPVALEKILGNKNFIrrtgyvtkvgkpffRNGLLMSDGDT-WRIHRKIISSTFHNnvldqFV 164 Zootermopsis ne...
EFA05711      67 PDLAKAWmgpelYYLITK-PEYLEVVLNHNATLekmdlyk-firpivGDGLISSPVKV-WKRHRKIIAPTFNQkvlneFP 143 red flour beetle
XP_017769643  64 KEIIALWig-pqLHVVILcAKYTEIILKNSRSTvkseeyq-flkswlGDSILISEGAK-FRRNKKLLTPSFHVlnlkqYT 140 Nicrophorus ves...
XP_003246356  89 KSLFKLWvl-nnLYIVLTrPEDIEMVLTNPKLQkkskeylvlqesimGQGIFSIDDIKkWKSNRKMVSGGFNFtitksFI 167 pea aphid
XP_011558236  69 KYLVKLGp---lDQVIITkTEDIELILSSNVLIeknfvyk-flepwfGNGLLILTGKK-WRSHRKMLTPAFHFkilesYV 143 diamondback moth
XP_021932481 136 GPVVRFWkg-dkLYVVLSnAESIETLLTNKALNkkntf----vssiaSSNGIVTSGDK-WKNHRRIISSTFNSnvldqFM 209 Zootermopsis ne...
EEZ99364      65 PSPVRLWvg-pkLVLFVKdPNQLQLILQSSKITtksflyr-flepflGKGLFTSSGPR-QKHHRKLLQPLFSQrmiegYC 141 red flour beetle
Feature 1                                                                                        
5T6Q_A       133 AIFADSTRIMLEKWEkkacegk-sfdifsDVGHMALDTLMKCTFGkgdsg----lnhrdSSYYVAVSELTLLMQQRIDsf 207 rabbit
XP_022205802 149 PIFFEEAKIFASKIPcgeev-----dvfpRFGLCALDIICRTAMGvhvhs----qegkgKEFVEGMETLLQIAHWRLVrp 219 brown planthopper
XP_022192967 157 PIFYKQATKLANKTKdkeqv-----nifsAVGLCTLDSICNTAMGinifa----qdsdnNTFLQDFYSILKVWHTRMTnp 227 brown planthopper
XP_021918791 165 ENFTKNSAILVSKMRnncnet--afniypLISLCTLDVICETAMGttvna----qldddGKYVRNVLRSLQLLSERFMrp 238 Zootermopsis ne...
EFA05711     144 GVICEQVNFLIELLRkecdkg--eidhcrYVTNCAIDIVGETIFGvsiga-----qtggKSYSLIFDKWMEVVFMRIFrl 216 red flour beetle
XP_017769643 141 HVFGEYAQKLNCDLEekange--efdihpFLSLTTMYVLLETSLGvktet----lgvdaLDYAEAVERLGRCAHQRVYkv 214 Nicrophorus ves...
XP_003246356 168 PIFYEESNVLDDILKqkcdlksnecdisvPVSMATMEIIGRTALGvkfna----qnggrHRFVENLQTVMHAWEYRVThp 243 pea aphid
XP_011558236 144 EVFQEEAQVLADQLLdqgdgd---iemshITSQRSLFALCRTAIGfdmnv-----nkdmSDFAASTQMIKKIMNQRVFss 215 diamondback moth
XP_021932481 210 GNFVENSSILTRKLKslaggc--ivdiypFVCACALDVMCEATMGtnvnsqmegngvfvKILLCAMEEVGETFKKPWTie 287 Zootermopsis ne...
EEZ99364     142 HLFQKHSKKFVEDLRknan------gpefNISTFLQFTAFEATMDllledqd-thsidyNEIPNYVRKFYEIVFTRVKsf 214 red flour beetle
Feature 1                                                                                        
5T6Q_A       208 qyhndfiywltphgrrFLRACRAAHDHTDRVIRQRkaalqdek-----------------erekiqnRRHLDFLDILLDv 270 rabbit
XP_022205802 220 ymindtifsmlpikkkHDEAQKNVFKFTESVIQDKrqklnsqkskcnnnnnnnndeknddnkyflsgERAMPFLDLMMAm 299 brown planthopper
XP_022192967 228 wimldlmfnvsryreiHDNAADRMKYFTNEILHLKrdkygvnk----------------sgvtvrseSRSTAFLDMMLTc 291 brown planthopper
XP_021918791 239 wlsidwifnltrlgkeQAATLEYLHGNAQQVVSEKlakfhasgrqk-----------tqvedlqsvkRKKLSLLDLLIEd 307 Zootermopsis ne...
EFA05711     217 dyqfewifswtkaskiQEEVKRIIHTMTRDIIEKKkeqigc--------------------qleaddEKKKPFLNLLVEk 276 red flour beetle
XP_017769643 215 wlrfnaifrfsklrqtQEKYLKVVHPLTERVIAERkksyln---------------------gdsdeRSWPLFIDGFFKa 273 Nicrophorus ves...
XP_003246356 244 wylsktlfqlssvkkkHDQSQKIINEFTDEIIKKKldelnqnannk----------nkvetddedvcRKTKTVIEILLGn 313 pea aphid
XP_011558236 216 wkfidplyqltgeakkLRECLNVTHSTFFTALRAKqesmkemmeliasgk---etlesitkeddfftKKRMTFIELLLLs 292 diamondback moth
XP_021932481 288 dwihyg---kkrnekdKEICAKYFHGVVDKVIEDKleshrngfrqnr--------dgkqveylqwirGKEMCLLDLLIQd 356 Zootermopsis ne...
EEZ99364     215 wlhld----iffklssYYREQTKLQSLATTVINEItetnvpkiiek----------ikaerkladaeIRVPSMLESIAEm 280 red flour beetle
Feature 1                           #  ##  #                                                     
5T6Q_A       271 rgesgvqlsDTDLRAEVDTFMFEGHDTTTSGISWFLYCMALYpeHQQRCREEVREILGdqdsfq---wedlaKMTYLTMC 347 rabbit
XP_022205802 300 dtde-msltDEQLRDEAITIIIGGQETTTTELTFTLLMLAIHhnVQAKVLDEIDLVFGsdlnhtp-tiedlqKLEYLERV 377 brown planthopper
XP_022192967 292 wse--hglsDTELKDEIITLILAGQETTATVNSFALIMLAYHqnIQLKVQEELDSIFEqwrendcpsfedlqKMNYLEMV 369 brown planthopper
XP_021918791 308 eq-----ltPDEIHDEVVTIVSAGSETTATTCCYVLSLLGVHqdIQERVVEEQKIVFGddihrpv-tsedlpHMPYLEQV 381 Zootermopsis ne...
EFA05711     277 hln--neltLQELEDEVNTFLLAGSDTNATSGSFILTLLGMHqdVQDKLYEEVSKILGperppt---lddlpKLKYTERV 351 red flour beetle
XP_017769643 274 rdeqgqglsDQEIKDEVMTMMFAGQDTTTVSVGFALSLLGLNpdIQDKLVMEIDKVFGdseral--dyedckNLPYMEQV 351 Nicrophorus ves...
XP_003246356 314 yh----emsHEQIRDELVTIMIGGQETTAMANACAIFMLAHHpdVQNKVFEELQSIFStgdhnrpptyedlqQMEYLERV 389 pea aphid
XP_011558236 293 ktpegepltDEDIKNEVKTFMSAGHETTAMAAAFIMYCLAMNpdVQNKAFQEQLEISGgdltkpl-tyknvqDMKYMERV 371 diamondback moth
XP_021932481 357 ak-----lsLDDIRDELCTLIVTGTRVTALTCCYVLSLLGVYeeAQDRIFEEQKNIFGedilraa-tssdlsSMKYLEQV 430 Zootermopsis ne...
EEZ99364     281 vmenpdcltMQDCTDHLMTFMATSQDTQSSAVAFTCMMLGAYphIQDLVVQELREVMGkktsld---ltdvsQLKYLEMC 357 red flour beetle
Feature 1                 #   #                                                             ###  
5T6Q_A       348 MKECFRLYPPvPQVYRQLSKPVSFvdgRSLPAGSLISLHIYALHrnsdvwpdPEVFDPLRFSpenssgrhpyafIPFSAG 427 rabbit
XP_022205802 378 LKEVMRLYPSiPYFARVLEEEVTLsnnYTLPKECIVCIFNYGLHrhpesfpnPERFDPDNFLpercrgrspfafVPFSAG 457 brown planthopper
XP_022192967 370 IKETLRLFPAlPIIGRALNEDLQVn-nVTSPAGSTVGVFLYGTHrdpdlypsPNDFNPDNFLperqskrsnysfVPFGAG 448 brown planthopper
XP_021918791 382 IKEALRLFPPiPYLFRKVEKETDLgngYVLPAGCYSMVVTYTTHrnpqyfpdPERFDPERFSpenclgrhpyayIPFGAG 461 Zootermopsis ne...
EFA05711     352 IKESLRVFPGaPFVARVVEEDVNLg-dVIVPKGANIGLGYLHLHrsekywkePLKFDPDRFLpensinrhpytwLPFSGG 430 red flour beetle
XP_017769643 352 IQETWRLYPPiPLMGKMPTEDIQLd-eYTLPKGCTIAVMIMKVHrdpsqyprPNVFDPDNFLperikqrspysfIPFSAG 430 Nicrophorus ves...
XP_003246356 390 IKETLRIFPPlPVFGRSLEEEMKIg-eHLCPAGSTLMVSPLFVHssgqyytdPEKFNPDNFLpdtcrgrhpysfIPFSAG 468 pea aphid
XP_011558236 372 VKESLRLYPSvVAMGRKITEPTVLkdgTELPVGVSVLLVPYFTHrnpevfkdPLKFDPDRFLeqvs----lysyYPFSAG 447 diamondback moth
XP_021932481 431 IKETMRLYPPvPLLFREIEEDTQLengYILPKDSCAVIFSYMTHrnsayfsdPESFSPERFSggshp---pyayIPFGGG 507 Zootermopsis ne...
EEZ99364     358 LKESMRLFPVgPFIFRDTTEDFQFd-kMVIPEGVTVILSIYHAHrspehwekPDEFYPEHFApeamskrhpcafIPFSAG 436 red flour beetle
Feature 1         #####  ##   #                                            
5T6Q_A       428 pRNCIGQQFAMNEMKVVTALCLLRFef-------svDPLRLPIKLpqlvlRSKNGIHL 478 rabbit
XP_022205802 458 pRNCIGQKYAMLQMKTVVSTIFRHFrvtpgkrfqngAPIRIKATTt---iKCSNSVDI 512 brown planthopper
XP_022192967 449 iRNCIGQKYAMVQMKTILSTLLRRYrvspgsgspplDNLQLMITSs---lKPKHKINL 503 brown planthopper
XP_021918791 462 rRMCVAYKFGIMEAKTMLSTILRRFrivqtvggistLINDLESGVv---lKPANGFNI 516 Zootermopsis nevadensis
EFA05711     431 sRNCIGWKYGMMVMKIMTAMVIRKFrvkss--iksiGDIELTANVv---lKPKNGFRL 483 red flour beetle
XP_017769643 431 hRTCIGQRYAMLLIKVLLANILRRYtvts---tvpmKEFQLAAQTt---lKRKDGFRI 482 Nicrophorus vespilloides
XP_003246356 469 yRNCIGIKYGILQMKTVISTLVRKNtfspsercptpKHLRVMFLSt---lKFVDGCYV 523 pea aphid
XP_011558236 448 sRNCIGQKLAMTMLKCWMGTVIRTVelfp----pegAHPEVIVEIt---iNSATGVNA 498 diamondback moth
XP_021932481 508 sRICVAYKYGMMEAKTILSAVLRAYrirtp-ggvtsLDRNLQAGVv---lTPANGFSV 561 Zootermopsis nevadensis
EEZ99364     437 pRRCIAQHYSYTYMKILLATIVLNYeiec---rfkaEDVKLIADIs---iRPQQGYLI 488 red flour beetle

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap