1DKR,3DAH,6NFE,5MP7


Conserved Protein Domain Family
PrsA

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COG0462: PrsA 
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]
Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis
Statistics
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PSSM-Id: 440230
Aligned: 715 rows
Threshold Bit Score: 196.048
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1DKR_A         7 DKNLKIFSLNSNPELAKEIADIVGVQLGKCSV---TRFSDGEVQINI----------EESIRGCDCYIIQSTS--DPVNE 71 
WP_011510387   1 mSDIAIQYLPTSASDAKRLALQLGVSAHEITL---HHFPDGEMRVTA----------GPA--TSTVIVYASLH--R-PND 62 
WP_012521024   1 -mRLVVHAFADEEAPASRLAAALGVPLRLVDV---HAFPDGETLPRV----------PET--APTVIVYRSLD--R-PNP 61 
WP_012068884   8 ATNVVVVSNSSDNPFAIDVAYAMGQHEDIADLismKQFMNSEFCPRFisdeadfdniGRKLKGKSVIIVSTGShvKSRQE 87 
WP_013166010   1 mTSVALQYLPGAGRDAMRLARSMGIAAHEIAL---HRFPDEEFLVTV----------GPA--AATTIIYSSLD--R-PNE 62 
WP_013254030   1 MQNVVIVGTVADNPVVEDVAHHLQQHEDYSDLislKSFVNTEFCPRFiisdrsndqpGRQLEGKAVVIISTNYgsSSRDE 80 
WP_011159683   1 -mSVALRYLDSAADDAIRLAARLGVPSYLITQ---HRFPDGEIAVNV----------GPK--AEITILYLPLD--Q-PND 61 
WP_014557069   1 ----MIVPGSSSQALASALATELNKPLAAVTY---DQFPDGETLAAV----------PEF-DGDRAIIVATT----DTND 58 
WP_020962272   1 MEQIVIISGSQANALAQKVASQLGIPHYPSTI---RYFPDGELYLRL----------PTDVKGKKIILFESFA--RRPND 65 
WP_041402870   3 ESQPIIVGNLADNPFVADIAQHMNQSMHYSDLvslKSFLNNEFCPRFivdeeswqdvGNKLEGRTVLIVSTTQsmHPRDE 82 
1DKR_A        72 HIMELLIMVDALKRASAKTINIVIPYYGYARQDRKAr-S-----------------REPITAKLFANLLETAGATRVIAL 133
WP_011510387  63 KLIALLFAAESLRRQGSKRLVLLAPYFCYMRQDSAFh-A-----------------GEAISQRVIGKLIVDT-VDRVITV 123
WP_012521024  62 KLMPLMLACDAWRRAGAQRLVLVAPYLCYMRQDTVFe-P-----------------GQSLSRDVIGALLGAR-FDRIVTV 122
WP_012068884  88 LAMANLIIARAAKENGADRVILVEPDLFYSAQDRGPhqSlgetsferdiqdvkkfdGQPFTAKLYAQLLKLSGVDTVMTI 167
WP_013166010  63 KLVALLLAVEALRREGAERLVLVAPYMCYMRQDAAFe-P-----------------GQAISQRAIGKLLADV-FDRIVSV 123
WP_013254030  81 LAMRTLLIARAARDNGADKVILLEPDLFYSAQDRGPrrEhgytafvrneedyqkfdGQPFSARLYADLLKAAGVDEIVTV 160
WP_011159683  62 KLVTILFAAEALRREGCNRLVLLAPYLCYMRQDVAFh-P-----------------GDAISQKAMGRLLAGL-VDRVITV 122
WP_014557069  59 TWVELLQLQDAVIEAGATEVITVIPYMGYTRQDRAFk-S-----------------GHPVSARAMARAI-SPTTDRVILI 119
WP_020962272  66 ALVETVFLSETLHDKGAGEVILVAPYLPYLRQDSEFn-P-----------------GEIVSAKMFSTMLSKAGIDALVTV 127
WP_041402870  83 LAMRNFLIARAAKDNGAHRVILLEPDLFYSAQDRGPrkEhgfvdfqrsekdykkfdGQPFSSRLYADLLKESGVDEVITV 162
1DKR_A       134 DLHAPQIQG---FFDI----PIDHLMGVPILGEYFEGKNL-------EDIVIVSPDHGGVTRARKLADRLK---A-PIAI 195
WP_011510387 124 DAHLHRTSDiraAFPGi---EADNLSAIPAIMSALRS-ENi-----hPATVVIGPDFEARQWVSRLAECLG---L-TYTV 190
WP_012521024 123 NPHLHRTSDlsaVFGC----DADALSAAEDLARTLGG-D--------GEPVVVGPDVESAPWAADVAGFLG---A-PSLT 185
WP_012068884 168 HNHSDSVQK---MFTEvfegDFHNLIPYEIYAHYLLNSNIlnygedgEGLVLCAPDKGARDFVKEMFKTLGlskA-KFIM 243
WP_013166010 124 NAHLHRVADiqaVFPGg---DADDLSAMPAVADTLSS-VGy-----dQGTIVVGPDAESRRWVADLAERLH---L-DVAV 190
WP_013254030 161 HNHSVSVQA---IFMDrfegRFHNLLPDDLYADYISDSDVvs----qKGMVLCAPDKGALDFVRRVKKSVGrddV-PLVF 232
WP_011159683 123 DPHLHRTPRlgdVFPGi---TADELSAMPAIAAALRG-TLa------PDTVVVGPDSESQQWVDALAKLIG---T-RSAV 188
WP_014557069 120 NPHERSVAD---FFDG----HVTICDAASHLAESLPS-GL-------SEPLFIAPDAGAIELATAVRDEYG---TgSTDY 181
WP_020962272 128 DPHLHRFKDlseLFKM----KTLKVSAMPLLAEYFYN-YH-------QEALVVAPDEEAEQWAKLFSGKVN---A-PYIV 191
WP_041402870 163 HNHSNSVKR---LFMErfsgHFHNMQPSDVYANYIQESDIvn----rEKLILCAPDKGAFPFVKEVHSHFQdssV-PMIV 234
1DKR_A       196 IDKRRPRPNVAEVM-----N-IVG-NIEGKTAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNS 268
WP_011510387 191 AQKVRYSDQSVELR-----F-ANPsMFAGRPALIIDDIVSSGGTLIACAKALSAAGATAIDAVVTHALFPPELMVAFTKA 264
WP_012521024 186 LAKRRRGDREVELS-----V-PDPaMVAGRRAILVDDICSSGATLALAARRLVAAGAASVEIAVTHALFEPSADARLRAA 259
WP_012068884 244 LDKDRTAERKVEITlhkesEhTFD-GLDGASIVLFDDMVRTGSTVVKSCQFLQQINPERMVFAVSHFYASDEGRERMAHP 322
WP_013166010 191 ATKVRRGDETVDIG-----F-ANDaMFAGRPVLIVDDIVSSGGTLIACAKALARAGASKMDAIIIHALFDEGLVDTFANF 264
WP_013254030 233 LDKCRKDERCVEIDlspesEiALS-DLAGRDIVIIDDMVRTGNTIIEACRLLKSAGPNRIVFFVTHFYSSRECRSNLNDS 311
WP_011159683 189 AQKIRHGDRSVEIA-----F-GDAsAIAGRPALLVDDIVSSGGTLIACTRALLGAGATSVDAVITHALFPPAMLRDFAAA 262
WP_014557069 182 FEKTRHSGTDVDMN-----I-TDT-NVSTRDVVVVDDIIATGVTMSTAVGHLNDGGAARVYIGCIHPLLARGARTRLERA 254
WP_020962272 192 LEKHRFGDTEVEVS-----Gs----IPKGTTAVIVDDIISTGGTIVEAAEKLKEHGFTSIHVCVTHALLVQDAEAKIFQA 262
WP_041402870 235 LEKERLGERKIRMDvnpesDlTFK-DVKGKQVVVIDDMVRTGSTIIEACSRLKEAGAERVVFMVTHFYSSQEGRIKLNHK 313
1DKR_A       269 TIKELVVTNSIKL--Pe--EK--KiERFKQLSVGPLLAEAIIRVHEQQSVS------------------------YLFS 317
WP_011510387 265 GIHSIRSTHSVPH--A-----------TNTFDLDDLFASALHCEFGDTTPL------------------------EVIS 306
WP_012521024 260 GVQRIVSTDSCPH--P-----------TNAVALAPLLAVALAGegAQPREGvk---------------------rAIRS 304
WP_012068884 323 AIGEILTLNTLPTilNrdeQGrlR-KKMVVLKVEKWLAQELCNILDLPQTHepnpykidmssknprfkrkiwfseELSE 400
WP_013166010 265 GIRSVRSTSSIPH--P-----------TNAIALDSVLIAALHRELQGAER----------------------------- 301
WP_013254030 312 VLDEIVTTSTIPEilNrdvQGrlR-HKMVVLQLSRWISNYLLRIIQPDSTPlpppfynedms--sknprwkghmgPLFS 387
WP_011159683 263 GIRSIRSTHTVPH--P-----------TNAITLDDLFVEALRDEIGTTFKEtra------------------------- 303
WP_014557069 255 GIERVIGTDTIER--E-----------VSAVSVAPTVAAAIEAVDIEKR------------------------------ 290
WP_020962272 263 GVKSLIATDTVIN--P-----------YMRVSVAKIIGEALERLMSHVGNR------------------------A--- 301
WP_041402870 314 AIDEIVTTSTIPQilNrdmQGrlR-HKMVVLRIARWISNYIHQQMEPESESltrpyytedms--sknprwkdplgPLFN 389
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