Conserved Protein Domain Family
bHLH_TS_FIGLA
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cd11422: bHLH_TS_FIGLA 
basic helix-loop-helix (bHLH) domain found in factor in the germline alpha (FIGLA) and similar proteins
FIGLA, also termed FIGalpha, or Class C basic helix-loop-helix protein 8 (bHLHc8), or folliculogenesis-specific basic helix-loop-helix protein, or transcription factor FIGa, is a germ-cell-specific bHLH transcription factor expressed abundantly in female and less so in male germ cells. It is essential for primordial follicle formation and expression of many genes required for folliculogenesis, fertilization and early embryonic survival. FIGLA knockout mice cannot form primordial follicles and lose oocytes rapidly after birth, whereas male gonads are unaffected.
Links
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Statistics
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PSSM-Id: 381428
Aligned: 11 rows
Threshold Bit Score: 95.1129
Created: 22-Sep-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #   # ### #    #                          ####                   
Q6QHK4        67 RRVANAKERERIKNLNRGFARLKALVPflp---------qsRKPSKVDILKGATEYIQVLSDLLE 122 human
BAE06422     117 RREANARERLRVRNLNSGFAKLRRILPtvp---------pnRKPSKVDTLQGAIDYIHQLEQLLE 172 Ciona intestinalis
NP_944601     68 RQLANAKERLRVRSLNSMFSYLRRIVPvmp---------rdRKPSKVDMLKAATEYIRLLSAVLN 123 zebrafish
XP_002586647 312 RREANARERQRVRNLNTGFAKLRRMVPslp---------pnRKPSKVDTLHAAMDYIRTLQYVLQ 367 Florida lancelet
EMP30513      85 RQAANAKERERIKNLNSGFSKLKTIVPlip---------kdRKPSKVDTLKAATEYIRLLHLILE 140 green sea turtle
NP_001088667  56 RQAANAKERERIRNINSGFSKLKTIVPlip---------kdRKPSKVDTLKAATEYIRLLHDILE 111 African clawed frog
XP_014350893  60 RQSANAKERERIRNLNRGFSKLKMLVPlip---------rdRKPSKVDTLKAATEYIRLLHDILE 115 coelacanth
XP_007882962  94 RKVANERERLRVKNINGGFSKLKRIVPlip---------rdRKPSKVDVLRGATDYIRLLRVVLE 149 elephant shark
PIK37102     463 RVDLNARERERVSLLNNGFDCLRRVLPwst--------kigRRVSKVDTLRGAISYIDFLQRLLK 519 Japanese sea cucumber
XP_006824063 524 RRKANARERIRVNKLNSAFDLLRSVLPkdllmktehtgkrvFKMSKVETLRCAISYMHKLEMILR 588 Saccoglossus kowalevskii
NP_508119      3 RERANARERCRQKSIGNAFNMLRNHLPkql---------rdRKPSKAETLKSAAQYISHLLRILE 58  nematode

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