Conserved Protein Domain Family
FAM131

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pfam15010: FAM131 
Putative cell signalling
The precise function of this protein family is unknown, however studies have shown it undergoes Protein N-myristoylation; a type of lipid modification in eukaryotic and viral proteins. Protein N-myristoylation is usually an irreversible co-translational protein modification which is useful in cell signal transduction pathways. This indicates that FAM131 may have some sort of role in cell signalling due to its ability to be myristoylated. This family of proteins is found in eukaryotes and are typically between 257 and 361 amino acids in length.
Statistics
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PSSM-Id: 464442
Aligned: 10 rows
Threshold Bit Score: 341.943
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005461055   1 MLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWCK-----PIDTTAALESDFNSYSDLTE 75 
Q8BWU3        86 MLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWSK-----PSDSPAALESAFSSYSDLSE 160 house mouse
XP_007486246  90 MLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWSK-----PRDSASALESAFSSYSDLSE 164
Q3TY60        39 ILPKLKRNSNAYGIGALAKSSFSGISRSMKDHVTKPTAMGQGRVAHMIEWQGWGKaptiqPQHSHEAVRRDTDAYSDLSD 118 house mouse
XP_015216920  42 MLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWCK-----PTDSPAALESDFNSYSDLTE 116
XP_023207242  21 MLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWCK-----PIDTPAALESDFNSYSDLTE 95 
TNN01273       1 MLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWCK-----PIDTP-ALESDFNSYSDLSE 74  Takifugu bimacu...
XP_006001413  39 ILPKLKRNSNAYGIGALAKSSLTGISRSVKDRITKPTAMAQGKVAHMIEWQGWSKqqhpyRQPIHETVRMDVDAYSDLSD 118 coelacanth
XP_016851166  47 MLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWCK-----PMDSPVALESTFNSYSDLTE 121 green anole
XP_010591120   1 MLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWSK-----PSDSPAALESAFSSYSDLSE 75  African savanna...
XP_005461055  76 GEQEARFAAGVAEQFAIAEAKLRAWSSVDGDESNDDSYDEDYLPANEPttq----stD-VPsyP--PYLKDl-------- 140
Q8BWU3       161 GEQEARFAAGVAEQFAIAEAKLRAWSSVDGDDSTDDSYDEDFTGGIDT---------DmAG--PlgSHLQD--------- 220 house mouse
XP_007486246 165 GEQEARFAAGVAEQFAIAEAKLRAWSSVDGEDSTDESYDEDFAAGADSpq-----ppDiAGqlG--PHLQDl-------- 229
Q3TY60       119 GEKEARFLAGVMEQFAISEATLMAWSSMDGEDMSVNSTQEPLDCNYSDnyqelmesqDaLAqaPmdGWPHSy-------- 190 house mouse
XP_015216920 117 GEQEARFAAGVAEQFAIAEAKLRAWSSIDGEDSNDDSYDEDFGPASEPsqtl--qnsDtVSsyP--SYLRDf-------- 184
XP_023207242  96 GEQEARFAAGVAEQFAIAEAKLRAWSSVDGDESNDDSYDEDFLPASEPttq----stE-LSsyP--PYLKDl-------- 160
TNN01273      75 GEQEARFAAGVAEQFAIAEAKLRAWSSVDGDESNDDSYDEDFLPANEPstq----stD-VPsyP--PYLKDl-------- 139 Takifugu bimacu...
XP_006001413 119 GEKEARFAAGVMEQFAISEATLIAWSSMEAEEMSMGSTVDNMANSTELnme----nqEnQAqnMyeVWPHSy-------- 186 coelacanth
XP_016851166 122 GEQEARFAAGVAEQFAIAEAKLRAWSSVDGDDSNDESYDEDYATPSDTt--------QpADavP------Qiapstllkg 187 green anole
XP_010591120  76 GEQEARFAAGVAEQFAIAEASxRAWSSVDGeDSTDESYDEDFAGGTDT---------DvSGqlPlgAHLQD--------- 137 African savanna...
XP_005461055 141 -IHSQLCQHLGFR---------------SPCCESRgggvegggsGEPSPTAgSPDTLCSSLCSLdEQHPLlrdlggh-rg 203
Q8BWU3       221 -LFTGRRFSRPVR---------------QGSVEPE---------SDCSQTV-SPDTLCSSLCSL-EDGLL---------- 263 house mouse
XP_007486246 230 -L-TGRRYSRPLR---------------QGSCDPE---------SDSSQTV-SPETLCSSLCSL-EDGLL---------- 271
Q3TY60       191 -V------------------------------------------SQGMYCLgSSDAWEASDQSLi--------------- 212 house mouse
XP_015216920 185 -LHSHVCQQRSSR---------------QGSSEQEn--------SDTSPTV-SPDTLCSSLCSL-EDHPLlkd------- 231
XP_023207242 161 -IHSQLCQHLGMQ---------------RPCSESRggisegggsREPSSTAgSPDTLCSSLCSLdEQHPLlrdlrth-rg 223
TNN01273     140 -INSQLCQHLGLRgpccegggggeggssGE----------------PSPVAgSPDTLCSSLCSLdENHPLlrdmgsqqrg 202 Takifugu bimacu...
XP_006001413 187 -V------------------------------------------SQGMYCLsSSDAWEQSDQSLi--------------- 208 coelacanth
XP_016851166 188 fLHS-RLCQLNAR---------------QGSCDPE---------SDSSQTTiSPETLCSSLCSL-EDSLLlk-------- 233 green anole
XP_010591120 138 -LFGGRCFSRPLR---------------QGSVEPE---------SDCSQTV-SPDTVCSSLCSL-EDGLL---------- 180 African savanna...
XP_005461055 204 thshSNAAELAAKILSalhgrEElLLARLqrvgqsgPGGG---DCGFQSLGVVGRgirpcggqDSPCYSMSYSDTYL--- 277
Q8BWU3       264 ----GSPARMTSQLLG-----EElLLARL-------PPSR---ESAFRSLGPLEA--------QDSLYNSPLSESCL--- 313 house mouse
XP_007486246 272 ----GSPAHLSPSLLT-----EElLLSKL-------PPSR---ESAFQSLGPLER--------RDSFYSVSYTESCL--- 321
Q3TY60       213 ----ASPA--TGSYLGpa--fDD-SQPSLhd----mgPSQ-----------------------PASGYSAQEPPPLLgvd 256 house mouse
XP_015216920 232 --lgSSPVDLAAKILGalqggEE-LLSRLq-------rGR---ESAFRSLGHLVC--------EDSSYSVSYTESCF--- 287
XP_023207242 224 nhaqNNAAELAAKILSalhggEE-LLARLqrvghsgPGGG---DCGFHSLSGGGRgsrsyggqDSPCYSMSYSETYL--- 296
TNN01273     203 thhhGNASELAAKILSalqggEE-LLARLqragqggtgsgdfhs-----lggagrgvrpcggqDSPCYSVSYSETYL--- 273 Takifugu bimacu...
XP_006001413 209 ----ASPA--TGSYCGqn--yEE--QPQGqregistPPTQqqlQPHFISH-------------TPPLVDIWQGQSNMsha 265 coelacanth
XP_016851166 234 --elSSPSELAIKLLGslsgrEEaLLSKL-------PATQtagECAFRSLAQLEC--------QDSLYSMSFTESCL--- 293 green anole
XP_010591120 181 ----GSPARLASQLLG-----EElLLPKL-------PPSR---ESAFRSLGPLEA--------QDSPYNLPLVESCP--- 230 African savanna...
XP_005461055 278 --------------------------------SPGEDDDTP----CKDYDGTVCQVEAerngv--eyppNYDPRRRVSDV 319
Q8BWU3       314 --------------------------------SPAEEEPDS----CKDCQLLCPLPTG-----------SWERQQQVSDV 346 house mouse
XP_007486246 322 --------------------------------SPAEDEPIA----CKDCQLLGPAPGGswe---------grRRRKVSDV 356
Q3TY60       257 tdwasevggve--------largpveeekrplAPEEEEDAG----CRDLESLSPREDPems---------taLSRKVSDV 315 house mouse
XP_015216920 288 --------------------------------SPEDEEDLA----CKDYDS-VCKDEC-----------DYPGRRKVSDV 319
XP_023207242 297 --------------------------------SPGEDDDTP----CKDYEGTVCQKEVdgqgv--dyppDYNPHRRVSDV 338
TNN01273     274 --------------------------------SPGED-DSP----SKDYGSTVCQ--VeadgneveyppDYDPRRRVSDV 314 Takifugu bimacu...
XP_006001413 266 yalqevgryvgvpcqdrgepqvddapllskkgSP-EEDDVL----CKDFDSLSPREEPmeq--------ggmVRRKVSDV 332 coelacanth
XP_016851166 294 --------------------------------SPTEEEEEEegvlCKDCEAhe---------------dSCHVRRKASDV 326 green anole
XP_010591120 231 --------------------------------SPAEEESAP----CKDCRALCPLPAG-----------SWEWQRPTSAV 263 African savanna...
XP_005461055 320 ASSGVVSLDE 329
Q8BWU3       347 ASSGVVSLDE 356 house mouse
XP_007486246 357 ASSGVVSLEE 366
Q3TY60       316 TSSGVQSFDE 325 house mouse
XP_015216920 320 ASSGVVSLDE 329
XP_023207242 339 ASSGVVSLDE 348
TNN01273     315 ASSGVVSLde 324 Takifugu bimaculatus
XP_006001413 333 TSSGVQSFDE 342 coelacanth
XP_016851166 327 ASSGVVSLDD 336 green anole
XP_010591120 264 ASSGVVSL-E 272 African savanna elephant
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