Conserved Protein Domain Family
Gpi1

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pfam05024: Gpi1 
N-acetylglucosaminyl transferase component (Gpi1)
Glycosylphosphatidylinositol (GPI) represents an important anchoring molecule for cell surface proteins.The first step in its synthesis is the transfer of N-acetylglucosamine (GlcNAc) from UDP-N-acetylglucosamine to phosphatidylinositol (PI). This chemically simple step is genetically complex because three or four genes are required in both yeast (GPI1, GPI2 and GPI3) and mammals (GPI1, PIG A, PIG H and PIG C), respectively.
Statistics
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PSSM-Id: 461527
Aligned: 90 rows
Threshold Bit Score: 163.113
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGG12834                 172 VHAI-------NANTTQINH--SQELNERAHgkylsdvtnqdnnqdhskakskhpwpkpdsffaclmlsTTVGLRATKRY 242
XP_002139278             270 LKGI-------AYKFNTQSQwiVLYNILIINy-------------------------------------DNFNHNYDAIK 305
CAG25004                 419 WHNI-------FRSFMKNKQnpSEYYKYREIl------------------------------------------------ 443
XP_009400248             342 WENV-------HIRSCQFLYwpIFLQDTGVSskpnve------------------------------------------- 371
CBI30070                 209 WKNI-------RIRCCQILYwpIFLGGDYHRslscve------------------------------------------- 238
XP_006358033             334 CKNM-------EIRCCQLLYwpVILKDYGLRsqscve------------------------------------------- 363
KRH66835                 139 WINM-------RIRCGQILYwpIFLRENDPRsqscve------------------------------------------- 168
JCVI:AT3G57170.1         168 WINF-------RIRSCQILYwpIFLEEIDMMsiscvk------------------------------------------- 197
WGS:AAFB:cds.EHI_069120A   3 WNQL------------KLSQwnNHFIKSRKQ------------------------------------------------- 21 
EFC37729                  93 NSRIiltdhsdDYSINNIYYiyYDRNTKYKYsldrdeektlsslehlnng-nskarreaieyslfntpiNSSILKKHLEN 171
EGG12834                 243 gekslprclsagpnmsgictytyttvIELFNTLWL-----------------IANDIIFGRSSATFLME-NRNVLAA-WL 303
XP_002139278             306 --------------------------VLLYSTITS-----------------IIIDHIFGVLLIYIINS-FSMQILQ-FI 340
CAG25004                 444 -------------------------lIRIIN---------------------LIIDIFLGFLIFLLLYF---NVINLhYI 474
XP_009400248             372 ---------------------yahkaALRKHFMWSn----------------VLMDVLFGTVLGVLLLT-NVEAICT-WV 412
CBI30070                 239 ---------------------yaekaALHRHAMWSc----------------IVVDVFLGSLIGLALLF-HAESACL-CV 279
XP_006358033             364 ---------------------yaekaAFHKHSMWAs----------------LVVDLLLGNFLGIILWS-RARAACV-WV 404
KRH66835                 169 ---------------------yvekaAMHRHSMWSt----------------LVVDILLGNLVGWALLY-RAESVCL-SV 209
JCVI:AT3G57170.1         198 ---------------------haeeaALQRHSTWSa----------------MAVDLVLGNLIGLGLLF-NTESVCS-FV 238
WGS:AAFB:cds.EHI_069120A  22 ---------------------------------FFediknkklskhmqntiaVIVDHLLGISLFIILYK------VDiFS 62 
EFC37729                 172 --------------------------ISRIGMSFN-----------------MILDLILGFLIIYHVWKlDESTLIDlKK 208
EGG12834                 304 ETNLE-EYTVAFIKKALQWT-Ns-yPVGLKLNDELCETFYTGSVLIVDLWHA-----YVLKPTFga---lPHILLLTGYA 372
XP_002139278             341 SKVYY-FLYNDAIYLQFNWL-A---SSELRLNKDLSSFLISLLFEAFQLWKSi---tNYIFSDI------ELIFFFLKLL 406
CAG25004                 475 SEKAQiFYGTSTLTSILGTL-Lq-nPLGFKLNNNFTSFIGSILVSILDKWDLftnti---------pvnnSTVLNFVGYT 543
XP_009400248             413 LVTVG-LLTNDLLRSGCVWL-Mg-vPAGFKLNNELAELVGMISLNAIQIFSTl---wFFLGAFL------RLYIQVLAVL 480
CBI30070                 280 LKFAH-NITNNLLRSGCVWL-Mg-vPAGFKLNTELAGILGMISFNAIQIWSTl---wFHMGFLF------IYFIKGLAIS 347
XP_006358033             405 SSFSE-NATNYLLRTGCVWL-Mg-nPAGFKLNTELAGVLGTISLIAIQIWSTl---wWLLGFFL------IHLIKVVAVF 472
KRH66835                 210 LNFMH-GFS-TFLRSGCVWL-Mg-nPAGFKLNAELAGVLGMASLNAVQIWSTl---wIFVGYIF------NYIIQGLSVL 276
JCVI:AT3G57170.1         239 FDFAK-EFTNGILRSGSVWL-Mg-vPAGFKLNTELAGVLGMVSLNVIQIWSTl---wVFMASFI------FCLIRVIAIL 306
WGS:AAFB:cds.EHI_069120A  63 YVFPLlFRLINFIEHSVKWF-It-nPGGFKFNINFNYFLSSLSLFFLHFWRScl--iFIVLPSF-------YIFKIITFA 131
EFC37729                 209 RFISLyKYILINMFQHFEWLiKdsnPGGIKLNKQLNIILGQMALGGLRWWQTllsfgFYYLSDFftvdlfRVLIWSISSS 288
EGG12834                 373 SFC-GHTFTLAVASDFFALSTFHLWLVYRLFTFVFSWHLQTLQFLFNIFRGRKFNILRDRTEPAT-YQLDQL-ILGTILF 449
XP_002139278             407 SAVgGFSIAISFVWDIFNIYIFILHYIYVLFSKLHCINIQAISTFYHLFRGKKWNILRNRVDSTI-NNIEQL-LFGTILF 484
CAG25004                 544 SLL-GFSFFLSFVIDYLRFVTAHVTIIYLFLKKICTLFHKNMYSLYLLFNGKKWNILKLRVDTNY-YSNEEV-LLGTILF 620
XP_009400248             481 GIVfGSTVPVALCIDMLKLVTLHVYALHYLISFLYSQQIQALASLWCLFRGRKRNPLRQRLDSYD-YTVEQHvVVGSLLF 559
CBI30070                 348 GIIlGVTIPAALMIDMIALATLHVSSVNWFLSLLYSLQIQALAALWRLFGGRKWNPLRRRLDSYD-YTVEQH-IVGSLLF 425
XP_006358033             473 GSLfGLTAAAALIIDTISLATTHVSALQWLLTLLYSWQIQAVDALWRLFRGRKWNPLRQRLDSYA-YSVEQH-VVGSLLF 550
KRH66835                 277 GILcGFTVPAALVIDMIALATLHISTLHWFISLVYSSQLQALAALWRLFRGRKWNPLRQRLDSFD-YTVKQH-IVGSLLF 354
JCVI:AT3G57170.1         307 GITfGATVSAAFVIDVITFATLHIMALHWAITLVYSHQIQALAALWRLFRGRKLNPLRQRMDSYG-YTVKQH-VVGSLLF 384
WGS:AAFB:cds.EHI_069120A 132 SLItGITGILSFFNDTLVLIFLPIELLSVFFSGLEQTHLSLIVSLFRLFMGTKYNPLRKRVDTLV-YEQDNF-LLGTILF 209
EFC37729                 289 CLM-GASTMLALVCDLLLVVSINILLFYRIISRLYNQLIHLIFSLWRLFRGKKANPLKKRLDNCEdYSNDQL-ILGIILF 366
EGG12834                 450 TLATFLFPTVLAFYLLLSVPRLLIVAIHAIIDTGLSLLNHFPLFTVMLRLKDP--ARLPG 507
XP_002139278             485 TISIFLYPTVAIFYVNFLFIWVPVFLINILFYMIIYIASHFPYFLTTMYFIYP--DHFNS 542
CAG25004                 621 TILIFLYPTIFVLVLVFGLIYLIINRIIYLLCVMEKIILYTPFYIFFIQPNCN--KYISK 678
XP_009400248             560 TPLLLLIPTTSVFYIFFTSLITAILSLCITFEIIISLVHATPYAEILLWIISR--RRFPS 617
CBI30070                 426 TPLLLLLPTTSVFYIFFTILNTTICLLCILVEITISIIHATPYSKIFLWLMSP--RRFPS 483
XP_006358033             551 TPLLLLLPTTSLFYIFFTIMKTTISFVCIAIQFGISIIHATPYIKIFFWFMRR--KRFPS 608
KRH66835                 355 TPLLLLLPTTSVFYIFFSIMDTTINLVCLLIEVTISVIHVTPYTKIFLWLVRQ--GRFPS 412
JCVI:AT3G57170.1         385 TPLLLLLPTTSVFYIFFTITSTTINSICMLIEFAISVIHATPYAEVMIWLVRR--KRFPC 442
WGS:AAFB:cds.EHI_069120A 210 ALLVFLLPTSIIYYLYFTFVLMIVQLFKKILSVLIVLIVEFPIDDIIASYNQPffNTQPH 269
EFC37729                 367 TICIFLYPTVAVYYLSFSFLFFSIVSIRKIITSIMVLIHNFPINQLL---------NLNG 417
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