Conserved Protein Domain Family
Fibin

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pfam15819: Fibin 
Fin bud initiation factor homolog
Fibin is a family of eukaryotic proteins expressed in the lateral plate mesoderm of presumptive pectoral fin bud regions. It acts as a signal molecule for the expression of Tbx5, a gene involved in the specification of fore-limb identity. Fibin is found to be expressed in cerebellum, skeletal muscle and many other embryonic as well as adult mouse tissues, suggesting roles in both embryogenesis and in adult life. Although Fibin is routed through the endoplasmic reticulum (ER) no significant evidence for secretion is found. Fibin is post-translationally modified and forms dimers when expressed heterologously and its expression is regulated by a number of cellular signalling pathways.
Statistics
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PSSM-Id: 406297
Aligned: 12 rows
Threshold Bit Score: 284.718
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_013978280  16 CGGYFDGPLYPEMSNGTLHHYFVPDGDYEENDDPEKCQLLFRVSE-RRRCPPGDAG-------------------PGrga 75 
XP_011605957  45 SPAVYSGPLQAEITNGTFHHFFVPDGDYEETEDLEQCQMLFKFSD-MHPCGGSEER-------------------DS--- 101
XP_004069626  41 saVYTGPLQPEISNGTFHHFFVPDGDYEETVDPEQCQMLFKFSDV-YPCGHAEEGSd------------------AA--- 98 
XP_007228284  21 csavydgpLQAEISNGTFHHFFVPDGDYEETEDPEKCQMLFKWLD-RRPCGEEEDR-------------------DT--- 77 
XP_002667824  34 CGAVYEGPLLPEMSNGTFHHFFVPDGDYEETEDPEKCQMLFKWID-RRPCPLEEDR-------------------DT--- 90 
XP_007247038  17 AHALFLGPLHPEMSNGTFHHYFVPDGNYEENDDPEQCQMLFRVTDeRRPCGEDADA-------------------DA--- 74 
XP_003969837  16 CGAYYSGPLQPEMSNGTFHHYFVPDGDYEENDDPEKCQMLFKVND-ERRCGLDEDQ-------------------DA--- 72 
OCA36445      16 CHGYYTGPLFPEMSNGTLHHYFVPDGDYEENDDPEKCQMLFKVRD-DRPCTYE----------------------DAl-- 70 
NP_001264523  16 CRGYFEGPLYPEMSNGTLHHYFVPDGDYEENDDPERCQLLFRVSE-QRRCGTAAAG-------------------EGl-- 73 
XP_003224297  20 CRGYFDGPLYPEMSNGTLHHYFVPDGDYEENDDPEKCQLLFRVSD-RLRCAALEDGalrapqqhqpqppppplpvPAl-- 96 
XP_005658260  16 CQGYFDGPLYPEMSNGTLHHYFVPDGDYEENDDPEKCQLLFRVSD-HRRCSQGEGS-------------------PAssl 75 
XP_005995133  16 CQGLFTGPLYPEMSNGTLHHYFVPDGDYEENDDPEKCQMLFQVND-KRKCGLEPDQ-------------------DS--- 72 
XP_013978280  76 lslSLRDEFTVLGRQVEDAGRVLEGLSKSISYDLDGEESYGKYLRRESHQIGDAYSLSDRSLAELESKFRQGQEQAGRPD 155
XP_011605957 102 ---AVRDDLIIAKLQAEDAARLLEGIGRTVEQDLDGEDTYGKFLQRELSQIGEAFSSVDKSLMELEGKFKQSQETELREE 178
XP_004069626  99 ---VRDDFVISKLQAEDAARLLESIGRTVAHDLDGEDSYGKFLQREISQISEAFSSVDKSLLELEVKFKQSQETELREEQ 175
XP_007228284  78 ---AVRHDFILLKQQVEDSARVLESLGRTISHDLDGEDTYGTYLRKELDQISEAFSGVEKSLLELEVKFKQGEDAEHREE 154
XP_002667824  91 ---VIREDFVIVKQQIEDAARVLETLGKSISFDLDGEDSYGKYLKREIEQIGEAFTNVEKSLLELESKFKQSQETEQREE 167
XP_007247038  75 ---AVREDFTLARRQAEDSARVLEGIARSVALDLDGEESYARYLRRETSQISEAFAASERALLELEGKFAQSRE--REEA 149
XP_003969837  73 ---VIRDDFTIIRRQIEDSARVLEGIGKSISYDLDGEDSYGKYLRRETAQISEAFTNSEKSLLELEVKFKQSQESELKEE 149
OCA36445      71 ---SLKDEFIIIKRQFEDAERVLQSIGKSISYDLDGEESYGKYLGRESSQISESFSTSDKSLTELEVKFKQSQENEKNEA 147
NP_001264523  74 ---SLREELTVLGRQVEDAGRVLEGIGKSISYDLDGEESYSTYLRRESAQISDAYSSSDRSLSELEGKFRQGQEQGGREE 150
XP_003224297  97 ---TLREEFTLLGRQAEDAARVLEGLRKSISYDLDGEESYGKYLRRESAQIGEAYANSDKSLGELEHKFRQGQEQEREGG 173
XP_005658260  76 lslTLREEFTVLGRQVEDAGRVLEGISKSISYDLDGEESYGKYLRRESHQIGDAYSNSDKSLTELESKFKQGQEQDSRQE 155
XP_005995133  73 ---LLRDDFVITKRQVEDAGRVLEGIGKSISYDLDGEDSYGKYLRREATQIGEAFSNSDKSLTELEIKFKQSQQNEVKEE 149
XP_013978280 156 -GRLGDDFLGMLRRTAALLKDTLAVAAGLGDRYELLALTVRSHGTRLGRLKNEHLK 210
XP_011605957 179 -QQLNGYVMKQVGDIRDTLRKTTDISAGLKDKQELLSLIVRSHGTRLSRLKTEYLN 233
XP_004069626 176 -QLNGYVVQQVSDIRGALRETTDISLGLRDRHELLSLIIRSHGTRLSRLKTEFLTv 230
XP_007228284 155 -QEFTKNFVSPVNSVRQTLQDTQLISTGLRDKHELISLIVRSHGTRLSRLKHEYLN 209
XP_002667824 168 -SEFSSNFIKPVYDVRETLQETLDISSGLKDKHELISLIVRNHGSRLSRLKNDYLN 222
XP_007247038 150 -RRPGDDFAGMAEHARDLLRETRNAATALGDHHELLTLVVRSHGARLSRLKNEYLK 204
XP_003969837 150 -HRLSDDFLTMVVQTRDVLKETVDISLGLKDKHELLSLIIRSHGTRLSRLKNEYMK 204
OCA36445     148 -KSINDDFVDMMIHTRGVLKETLDISMGLRDKHELLSLTIRSHGTRLSRLKNMYLK 202
NP_001264523 151 -ARLGDSFLGLLLHARALLRETRAISSGLRDKHDLLSLTVRSHGARLSRLKNDYLR 205
XP_003224297 174 gTRPGEDFLARVAHARALLAETLALSAGLRDKYELLALAVRSHGARLSRLRGQHLq 229
XP_005658260 156 -SRLNEDFLGMLVHTRSLLKETLDISVGLRDKYELLALTIRSHGTRLGRLKNDYLK 210
XP_005995133 150 -NRINDDFLDMIIHTRELLRETLEISTGLKDKHELLSLIIRSHGTRLSRLKNEYLR 204
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