5W5P


Conserved Protein Domain Family
phage_tailspike_middle

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cd20481: phage_tailspike_middle 
N-terminal and middle domains of tailspike protein in Acinetobacter bacteriophages
This model describes the middle beta-helical domain of Acinetobacter bacteriophage tailspike proteins, as well as a separate N-terminal domain that does not appear to be part of the beta-helical substructure. The N-terminal domain may be involved in virion binding, and the molecules form a homo-trimeric arrangement. A C-terminal domain that may be involved in receptor binding is omitted from the model.
Links
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Statistics
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PSSM-Id: 380473
Aligned: 14 rows
Threshold Bit Score: 293.542
Created: 31-Jul-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
homotrimer
Conserved site includes 87 residues -Click on image for an interactive view with Cn3D
Feature 1:homotrimer interface [polypeptide binding site]
Evidence:
  • Comment:derived from contacts observed in the reconstructed trimer structure, at 4A contact distance

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          #                          # # #               #   #                          
5W5P_A        36 SLKLKt---FDDLRNFKPiv------nGQTVYVGQRSn--------tYLQGGGLFYADt------------sDTTSLDND 86  Acinetobacter p...
WP_126644893   2 EIYES----ISELLNIQNpv------nGQTVYVKSYWe--------dIGEGGGYFIYD--------------STKALIND 49  Acinetobacter p...
EJP50527     241 KSRDE----MLAYANPKT---------GQVAHLLSVHapnf--allkPQDGDGFFIYD--------------ESKSNDNN 291 Acinetobacter b...
YP_009610331 169 DINDRlaitYPTAVGLVGkpn---lkdADVIYVQSYSn--------iFDGGDGYYRVSa-------------DTTTVADG 224 Acinetobacter p...
WP_116772795 154 STKDKvh-iVNDINALKRfka---kfdGQIVQTQCHTk---------LGFGAGKYRFQq-------------LSNLIDNG 207 Acinetobacter s...
OJZ15139       6 LIKKT----MADLRNLCA---------CEIAELQDGT----------YLGVQLLGYYQagdtpgp-ivyslsDTTGSDDG 61  Sphingobacteriu...
TIV38928     218 AARSQg---YAALAGAALapl----tfATVASLLADTvl-------sYTAGGGHVVVGsgdiiqaqgfryqvAASGASDH 283 Mesorhizobium sp.
WP_056370158  35 STRSAap-aLAQHIAVTDgg-----dvQQAIAVAPNPraliastrptLPVGSTIRTANgyl--------yrvAPATATDQ 100 Sphingopyxis
ASZ78808      91 FVGQAa--sIAEVRAIEPtk------pNERILMKQYGp--------iKGVGGGEFWYDe------------lDTTTADNG 142 Serratia phage ...
WP_133454988 108 YTHDEs--eLKVINNLSRdealaeidiSVKKFISENTpef----idkVATGEWLNANEfkvee-----pvatKTLLPSNA 176 Macrococcus canis
Feature 1                                 # #                                      # #####       
5W5P_A        87 g----TILVGId--GTRWKrkw-ntHADPCWFGADyt-gtEDCSAQVQKAVDvs--------ygRVWFGNADRSFKXXTP 150 Acinetobacter p...
WP_126644893  50 n----GIVINGw--MRQFEg-----DIDISWFGAKq---gENASPHIEAALK------------VAQSIVIRGNYLLTSV 103 Acinetobacter p...
EJP50527     292 g---gTVCNGW---VRQYAg-----DVDISWFGAQq---gADASPFIEEALK------------ISKSIVIRGNYTLETI 345 Acinetobacter b...
YP_009610331 225 a---yVIRINPnliATMLNtt---gSVDVARFGAVm---nADVGPFIEKAFK------------YFRDVCLTKPYKLNTV 283 Acinetobacter p...
WP_116772795 208 g----TIVASLvsaGVWILld---sEVSIQHFGGIgdyilEDGTVNPAPTNNilacqk-yidafDGNLNYGSGNYYVNGV 279 Acinetobacter s...
OJZ15139      62 g----SIIATA---GIKLEhkf-leAVNPLYFGAKag-ldTDSTPFIQQIFNs-----------GYRSIEITCQLLADSY 121 Sphingobacteriu...
TIV38928     284 -----NLITAG---GVKLYviipvaGLDPRQLGAPvn-giNDDAPFVEAAWLl----------sKHVKLAAGVSYLWKSV 344 Mesorhizobium sp.
WP_056370158 101 -----HLTTAG---GVKLYig--dpYVTPDALGAPvd-gvGDDAPYFERAFRi----------sRTVQLLATSRYRLASV 159 Sphingopyxis
ASZ78808     143 g----TILVTAg--GKRWKkimkdtGYSAEDFGADpn-gvADSRAAIQAAIDfvg-------tlKNKILYLTGTYRIEGD 208 Serratia phage ...
WP_133454988 177 qlkemRLVIDE---NKQYLf----nGIDWIEFGAIn----ADGLSLIRIEVDnlsnsieiepddLRESPDETDGDLLQKA 245 Macrococcus canis
Feature 1             ######                ## #                                   # #  #### #   
5W5P_A       151 VGLPTNSIVGDx---------LXEICGDGARVWVYSNTGIFTSKRSIGLEts-------tdDLYTAALEIGRGLRFQGdg 214 Acinetobacter p...
WP_126644893 104 IGIPDQNNYANk---------VTTIRGEGQATLTVNCSAGAVFTSSSAKAdpn-----niaNLYTGKIHITKVNFIGTti 169 Acinetobacter p...
EJP50527     346 CGIPDQNNYSPt---------VISIRGENQATLTVNCPAGAVFTSAAAKLnpt-----stsDIYTGKINVSDINFIGTti 411 Acinetobacter b...
YP_009610331 284 VGIPNQNNYSKn---------VYYLRGLGDPEITVDCPSAVFTSASAKLDpts------tvNKFTAKIDVSNISFIGTtv 348 Acinetobacter p...
WP_116772795 280 LGFPTVKITDGk---------IMNITSNDANVYVEGGEALYTSARSLTDPld-------ikDLYTSRIFATNVNYIGVgs 343 Acinetobacter s...
OJZ15139     122 LGLPDATLQRYp---------SHRISGKGGSVHLTNNVNDGWITSQSSLLnpg-----stgNLYTGKVFIDNLVVRNAgp 187 Sphingobacteriu...
TIV38928     345 IGIPNQTLYALd---------HYVLSGQGATVVMDGVAAGAEFLTSASAKaapn----stsDLYTAKVQISGINWKQVs- 410 Mesorhizobium sp.
WP_056370158 160 IGLPNQTLYDR----------VSMFLFCGGATIVANSPSVGGVPEAIFTSaaakaapesgdNLYTGKIFVVGGNWTQDh- 228 Sphingopyxis
ASZ78808     209 TTITLANGVQLlgtr--rgmtQGPQTVQGDTMRVVNDTTFHVAMTPGKTT-----------PLFTAGRDAVFSGFSVVyi 275 Serratia phage ...
WP_133454988 246 VNVLEQSNKNNksiklgriydIDKTIMLSVRVDLNVTSHININGRNGGLRlshdg-ymfdgVKSSGGIKCQQVKFIGSsf 324 Macrococcus canis
Feature 1                                 ### ## # #                          # # ## #           
5W5P_A       215 v--sqSVVVNG----------DRLYNVNXKGGRYLRISALVRATQPRrne-----ttGYVQSVTIEENHLALCNRIIDSk 277 Acinetobacter p...
WP_126644893 170 ---pnSVVFNG----------DRLYNLNIYDNNFSGNITIIKTYLKRel------grSYSQSCSIKDNYLANIYRVIETd 230 Acinetobacter p...
EJP50527     412 ---anSVIFNG----------DRLYNMKIHHNNFHGSVTIIKAVVKRla------drNYIQSVDINNNHMALVHRVIEAd 472 Acinetobacter b...
YP_009610331 349 ---anSVVFNG----------DRLYNINVHHNNFKGNITIFKAYVKRev------grQYTQSVSINHNHLTGVYRVIESd 409 Acinetobacter p...
WP_116772795 344 ----dSKVFNG----------DRLYNVIVTKNSFSKIKKIVHSYRKKlsds---ypnGYLQSFWMLDNQITQCHRIIDAk 406 Acinetobacter s...
OJZ15139     188 ---diGNIIDGtplsgtfvdgDRIYNVFITKCSFFRVKHVIKSYKEKrpndtdayknGYLQSVTITGNIFEQVERIVDAd 264 Sphingobacteriu...
TIV38928     411 ----sSVIING----------DRIYNVSFVGNNCAGITSVIKSFRSRvsn-----anGYIQSVTLSDNNFANVAKIVDAk 471 Mesorhizobium sp.
WP_056370158 229 ----pSVLFNG----------DRIYDLRLSQASFAQLDTVVKSFRAKgad----ypnGYIQSLGMSNCQFSNVRRWVDAk 290 Sphingopyxis
ASZ78808     276 nqpkeAATINDilty--gptiWASHSCSVVNVRYVAAWDFFNGRGEAhfis---diyGYAFNVDFHIEMCADVTRLKNIh 350 Serratia phage ...
WP_133454988 325 ----tKPIFNC----------NNLIQIVLNECDFIRTYSIFYADPKT----------GYLQSCRMTNCNSKGMMTYQIIa 380 Macrococcus canis
Feature 1                                        ##    # # #                   ## #  ###         
5W5P_A       278 ------------------------------rGFNVTVSRNFCESCYGGVYLDGd---gSPAVNVIRCDGNLWESSGVFAK 324 Acinetobacter p...
WP_126644893 231 ------------------------------kAYNFEFSDNKCETCQGGVYIGVsd-pwDPSAISLTMNRNLWEGGGIFLK 279 Acinetobacter p...
EJP50527     473 ------------------------------rAYNFNFSFNACENCIGGIYIGIda-pfDPTGMSVSIFRNLWESGGMILK 521 Acinetobacter b...
YP_009610331 410 ------------------------------kSYNLDFSYNMCEACIGGIYVGVda-pwDPNNISLTIHRNLWEGSGMLLK 458 Acinetobacter p...
WP_116772795 407 ------------------------------hGFNIKFNDNTCENNYGGLYIDGp---gDPAITQFRCNGNIFEGGGLFLK 453 Acinetobacter s...
OJZ15139     265 ------------------------------rCFNFTFKDNMCEGCISGIWFKNid--gKPTVNVARIVDNVFESGGVFLY 312 Sphingobacteriu...
TIV38928     472 ------------------------------rCYNFRWVNNRAEACTAGVYVDGp---dDAAVIGFSMMGGSFEGGGLSVK 518 Mesorhizobium sp.
WP_056370158 291 ------------------------------vGFDLSFDNLGGTNCDGGIYVDSvt--aDPAVISIRWKDIRFQDGGCALV 338 Sphingopyxis
ASZ78808     351 insnvyrpgwsildvaaprvtsrafemvqhdGIMFEGIHVFAKGTVWHNRQNS-----TARLCSLNGTDFLFDKCGTMLD 425 Serratia phage ...
WP_133454988 381 a-----------------------------kVYDVHILSNLVEWGRGGLIDISqgtaeDVCSIGLFIENNVIEGISEQIP 431 Macrococcus canis
Feature 1                   ## # ####                                        ## #  ###           
5W5P_A       325 L-------GAVYAGTFIGNYFEGNNtgdl------------ptlkCLIELGKtg-ttGYSSGVTFIGNQFGAAaa----- 379 Acinetobacter p...
WP_126644893 280 Tn------GGIIAGSVSFNYFENNTffda------------aiekCLISIDRsgvgsGYSSALVFETNLFSGN------- 334 Acinetobacter p...
EJP50527     522 Vq------GGLVAGSVSKNYFESNNiada------------atdkCQIYINRtgtgaGHSGGLVFDSNFFSGS------- 576 Acinetobacter b...
YP_009610331 459 Tn------GGIIGGTISANYFENNTfnda------------giekCLISINRtgtgaGYASGLVISGNTFSGN------- 513 Acinetobacter p...
WP_116772795 454 L-------GAILGGSIHENYFEANTleda------------stlkCHMDLRKis-ggGLHSGLSIDGNTFGATts----- 508 Acinetobacter s...
OJZ15139     313 S-------GPIAGGKISGNYFEGNNqpei-------------ktyKAHLYFKfg-aaTNYMGLAIDSNNFQAHed----- 366 Sphingobacteriu...
TIV38928     519 L-------GKSYGVGIRNIYFESNTtgdv------------vtekCDILVGDsa--qASSGSVLVDGCSFGTTsd----- 572 Mesorhizobium sp.
WP_056370158 339 L-------GKVVGGLFEGYYGETNAigda------------vmarCEIWFKRg---sAPSSGVSLASLQFQPSst----- 391 Sphingopyxis
ASZ78808     426 SdvnggvcCSLSNGVFIHDYHTNEGaalnltnpvgtqvtsyyltdWKWQLGSagtspGQGSWAANWMNFNSAAgtrvwld 505 Serratia phage ...
WP_133454988 432 Ii-----tGAHGKAVISNNYFEGNTy-------------------TDIDMSRg---sLPHRGITIRDNSFGDYvissn-- 482 Macrococcus canis
Feature 1                                                              ## #  # ## #             #
5W5P_A       380 ----------------------yKADVNYADVKFTASlsg-----------tnlDVLAPPTFVGNWTNAYRXWSeg-qVV 425 Acinetobacter p...
WP_126644893 335 -----------------------SSITDYVDVRYVNQniqss-------snsksATTKPPVFISNWSSSFNLTNd--pSA 382 Acinetobacter p...
EJP50527     577 -----------------------ASVAGYCDVRIIGTpdvsg-------sttknAITAPAVFIGNWSENERLVDn--pSA 624 Acinetobacter b...
YP_009610331 514 -----------------------GAIPDFVDVRYVNQstess-------stsktANVKPVVFIGNWSNSYLMTNf--aGA 561 Acinetobacter p...
WP_116772795 509 ----------------------qKTDTEWVDVRLDPFys-------------stGLVAPPTMNNNWSNSYQMVThg-aIQ 552 Acinetobacter s...
OJZ15139     367 ----------------------qKIDVEFSDIKFDGNftt------------daEYLGNVSIRNNNSNSYSLVEpqsrIK 412 Sphingobacteriu...
TIV38928     573 ----------------------qRADVNYACIKARSNgt--------------nANIGALEVRSCWTSGVRLWGya-tVL 615 Mesorhizobium sp.
WP_056370158 392 ----------------------qIADPDYRAIRWDDErnq------------pgTIAAPPSLRNCWTTGANLITpg-rVV 436 Sphingopyxis
ASZ78808     506 ninilamgtlalnnnaqfnrvegSVTIGTRKINFRPQnanl----------venHRLVSIDPFTNIPYGFTKLGt---AV 572 Serratia phage ...
WP_133454988 483 ------------------kdscvKVGKGYSDISYDFRgnmgvktifdfsgsygkFDLAGGMLTYSRQPSYKNATl--aVI 542 Macrococcus canis
Feature 1        # #####   ###             ####
5W5P_A       426 TQFGNAFSGGNARr-----------HQAPK 444 Acinetobacter phage AM24
WP_126644893 383 ILIGNRILNRGILr----------nAYSPQ 402 Acinetobacter pittii
EJP50527     625 ILIGNRIKDRALMl----------nAYTPQ 644 Acinetobacter baumannii Naval-18
YP_009610331 562 LLINNRCSNRNTMf----------nAYSPQ 581 Acinetobacter phage vB_AbaP_B1
WP_116772795 553 TAFGNGGTGGVQKnaq------mgiPTSPA 576 Acinetobacter sp. JW
OJZ15139     413 FYEGNSITADMYAra--------rtVVSPT 434 Sphingobacterium sp. 40-24
TIV38928     616 VQSGNTIGAALTGgrqf-----spaPTSPA 640 Mesorhizobium sp.
WP_056370158 437 DFEGNGGTESRLLkna-------raPMSPQ 459 Sphingopyxis
ASZ78808     573 TVSGRNVTSTAATsptglgistrvaQTFPS 602 Serratia phage 2050H1
WP_133454988 543 HDLGGKSAKNAMTvsn------nsfMFYPN 566 Macrococcus canis

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