Conserved Protein Domain Family
API5

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pfam05918: API5 
Apoptosis inhibitory protein 5 (API5)
This family consists of apoptosis inhibitory protein 5 (API5) sequences from several organizms. Apoptosis or programmed cell death is a physiological form of cell death that occurs in embryonic development and organ formation. It is characterized by biochemical and morphological changes such as DNA fragmentation and cell volume shrinkage. API5 is an anti apoptosis gene located in human chromosome 11, whose expression prevents the programmed cell death that occurs upon the deprivation of growth factors and is up-regulated in various cancer cells. This protein has an elongated all alpha-helical structure, in which the N-terminal half is similar to the HEAT repeat and the C-terminal half is similar to the ARM (Armadillo-like) repeat. This suggests that API5 is involved in protein-protein interactions and may act as a scaffold for multiprotein complexes.
Statistics
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PSSM-Id: 428672
Aligned: 18 rows
Threshold Bit Score: 558.921
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002971368  11 IAMLYEYGERLSNSEDK-SKNESDYLGIIEAAKSKGKVKQLAAQLIPRYFKYFPNLSVRSLEAQLDLCEEEELGITVQAV 89 
XP_002522525  11 IEKLYEFGERLNESKEK-SQNLEDYQGILDAAKTSIKAKQLAAQLIPRFFKFFPQLSSQAVDVHLDLIEEEELGVRVQAI 89 
CBI30644      11 IEKLYEYGERLNEAKDK-SQNVEDYRGIIAAAKGSIKAKQLAAQLIPRFFKFFPDLSDAAVDSHLDLCEEEELGVRVQAI 89 
EFX89475       4 IDKLYQHYEILNEAKDDiAKHRKEYEDILLAVKGSDKEKKLASQFIAKFAKSFPDLENETIDAMFDLCEDDDVLIRKQAI 83 
XP_015787483   4 IDKMYDNYNILVDAGDKiTEHEDKYLEILNSVKGSPNEKRLASQFITKFFKHFPAHYNSAIDALLDLCEDDDINIRKQAI 83 
Q9V431         4 IERLYKCYEILSEAGDKiSEHVDEYKEILKAVKGTSKEKRLASQFIGNFFKHFPDLADTAIDAQFDLCEDDDTQIRRQAI 83  fruit fly
ETN60634       8 IEKLYKNYEILSDAKEKiTEHEAEYREILDAVKGSAKEKRLASQFIGKFFKHFPSLANTALDRQLDLCDDVDPQIRRQAI 87 
EKC39907       4 IETMYQNFGVLADAKEKaGEHEEEFLSILNAVKGSPGEKRLASQFITRFFKYFPSHAGTAINAMFDLCEDDDPMTRKQAI 83 
NP_955834      5 VEELYRNYGILADAKEDlSTHKDAYQVILDGVKGGAKEKRLAAQFIPKFFSSFPELADAAINAQLDLCEDEDVSIRRQAI 84 
XP_003385268   6 VEALYRNYGILADAGDKaGEQTEAFLGLLESAKGSAAVKRLVSGFIAKFARFFPTLEGDIMNVLFDLVEDDESLVRQAAI 85 
XP_002971368  90 RGLATICKDSKDL---LPKVADVLGQLLITEEPLEKDAVQKALMSILRQDAKATLTALFKHVENSD-----ENLREKVLA 161
XP_002522525  90 RGLPLFCKDTPEY---LSKIVDILVQILSAEEFVERDAVHKALMSLMRQDVKASLTALFKHIGSTDepsgdEH-RDRVIS 165
CBI30644      90 RGLPLFCKDTPEY---VSKIVDILAQLLTAEENVERDAVHKALLSLLRQDVKASLTGLFKHIMTVDdpstdENLREKVLN 166
EFX89475      84 KDLVNICKDNKGA---VRKIAYALAQILQSEDNSEVTAVHNSIASLYQIDPAATIEALFSELAEDN-----EVMRERTLK 155
XP_015787483  84 KDLPSICRDCKEY---VPRITDILAQLLLAQDATELQIVNNSLITVCKLDPKGFLGGIFLQIEAGE-----DITRERVIK 155
Q9V431        84 KDLPKLCQGNADA---TIRVGDTLAQLLILDDPTELQQVNNSLLAIIKLDTKSSIAGLFQQISTGD-----ETTRERCLK 155 fruit fly
ETN60634      88 KDLPQLGRESTDH---TPRIADILAQLLGSEDVSELQQVHQSLMTLTKYDALGSLTGIFSQIGTGD-----ETVRDRCFQ 159
EKC39907      84 KDLPTLCKSAPEQ---VSKIASALTQLMGTDDATENHLIQSSFLTLFKFDSKGSLDGIFSQILGED-----ETVREKAIK 155
NP_955834     85 KELPRFASGEN-----LPRVADILTQLLQTDDSAEFNQVNTALISIFKIDAKGTLGGLFSQILQGE-----DIVRERAIK 154
XP_003385268  86 KSLPELCKNNKSNkdlCTKVADVLTQLLVSDDPADVILVKSAMSTILIHDTPSALIGIFDQILGED-----ETLREKAIE 160
XP_002971368 162 FIREKVFPLKNDLLQPQEEMERHVTDLIKKSL-QDVTGAEFKMFMEFLKSLSIFGEKAPQERVQELLEIVESQADLDS-- 238
XP_002522525 166 FIRDKVFPLKSELLKPQEEMERHITDLIRKSL-IDVSGEEFKMFMDFLKSLSIFGDKAPPERMKELIEIIEGQADLDS-- 242
CBI30644     167 FIRDKVFPLKAELLKPQEQMERHITNLIKKSL-EDVTGAEFKMFMDFLRSLTLFGEKAPPERVQELIEIIEGQADLDA-- 243
EFX89475     156 MLAMKLRTLETGVM--KPEVKELLVKECKKIL-QDVTADEFVLVMAILGQCKI---ADSVSGQQQLVDLVAEQCNFTQ-- 227
XP_015787483 156 FLAAKIKTLPEDTW--TKEDEEFILAEGRKAL-QDCTKDEFVCLLNLLSSLKI---SKTITAQQVLVDMITEHAELDA-- 227
Q9V431       156 FIATKLLTMGPTVI--TKEIEDYIVEEIKKAL-QDVTADEFHLCMTILGATKL---GSTITGHAELVKLATEQAELNNtd 229 fruit fly
ETN60634     160 FINNKIMKIGPEII--TKPLEDFIIAEIKKALsEDVTADEFHQCMAILGQTKL---SKTLPGHVELVKIAAEQADLDNd- 233
EKC39907     156 FLGAKIKTLPEDTL--DSHSEELLINMCKKVL-EDVTKDEFIAIMEILKCQKS---MTTVQGRQQLVDIVTEQAELDE-- 227
NP_955834    155 FLSTKLKTMPEDIM--TKEVEDYIFVETKKVL-EDVTGEEFVLLMRILSGLKS---MQTVSGRQQLVELVVEQAFLEQ-- 226
XP_003385268 161 YVSVPLMDMRHVLFIPKEENEKCLLELVKKVL-GDVTAAEFETFVDVLGKLHH---LQSPEGANVIIDVIAEQAELDG-- 234
XP_002971368 239 -QFKVEDTDHIDRLMACLFMSLPFYARGASNSKFLNYINKSLFPAF--DKLPE-----DKKTELLKKIAESVQFSSAQD- 309
XP_002522525 243 -QLDVSDSDHINRLILCLYTALPFFLRGASSSKFLTYLNKLIIPAF--DELPE-----VRKLELLKVLAEISPCTLPQD- 313
CBI30644     244 -QFNVSDGDHIDRLISCLYMALPFFVRGASNSKFLNYLNKHIIPVF--DKLPE-----ERKLDLLKNLAESSPYSAPQD- 314
EFX89475     228 -VFNPADQEHLDRIIICIKHALPYFSTQVKSTAFVSYICDQVLPHR--NEIGQs----EQKLDIFKLLAELSSNCGPLDp 300
XP_015787483 228 -PLNPAETEQIEKFTMCVRAAIPHFSPFVPSNAFVQFICSQIIPCMt-EIVSLaienpNIEVEILQQLAELSAFIQPTNt 305
Q9V431       230 aDIIAVDDEVVERFIQCASAAAPYFSKTIKSTAFVAHVCDKLLPIKtwNMIATavsqdQIQLRLLKVFAEMITNTDKLDn 309 fruit fly
ETN60634     234 pGVLASDDETVERFINCATEAMPYFSSQVESTRFVKFVCEKFLQRNvwSLIGAadehhQTQLRLLKVFAEICPSCGTLEk 313
EKC39907     228 -PFVASDPDCVDRLTQCIKHAAPLFSKNVHSKAFVGYLCDNVLPHI--DQLASpedgvNGKLELLKLMAEISEFTGELEd 304
NP_955834    227 -ALNPADTDSVDRLLQCTRQALPLFSKNVHSTRFVTYFCEFVLPNL--SQLTSpvaelDIQLEVLKLLAEMSPYCGDMDk 303
XP_003385268 235 -NFQSEGPEAIDRFITCFRLALKYCKKGGSSYQFVRYASVEILPSF------AsitdaQKQQNVLQLLAEGSCYVQPENd 307
XP_002971368 310 -----ARNLLPTILQLLKKYMPKRK--------------TTEEFNYLHVECLLYAFHQLAHKSPNSTNSLCGYKIVTGQP 370
XP_002522525 314 -----SRQILPSIVQLLKNYMPRKK--------------NGEEMNFTYVECLLYAFHHLAHKAPNATNSLCGYKIVTGQP 374
CBI30644     315 -----SRQILPSVVQLLKKYMPRRK--------------TGEETNFTYVECLLYTFHHLAYKAPNATNSLCGYKIVTGQP 375
EFX89475     301 -----VVERIQIVYDTLLEYMPLPPpvleetngdgstteTEIRLEFTFVESLIFAFHQLARQHREFLI------------ 363
XP_015787483 306 nlpinLDECQEVVFSKLLEYMPSPSlstdv-----eeksEEPSLQLFPLESLMFTLYTLSVINPEF-NS----------- 368
Q9V431       310 -----ASERINAVYNVLLEYMPLPKlsde------dlgdTPPSFQFSHAECLLYALHTLGKNHPNSLSF----------- 367 fruit fly
ETN60634     314 -----ASEKVQAIYEVLLEYMPLPPlda--------dlnETPSFHFSHAECLLYALHTLGKQATEFLTF----------- 369
EKC39907     305 -----LEQRLKNLYDCLISYMPLPPeeene----desasGEPKLAFSSVECLMYAFHQLCRKQPSFLAA----------- 364
NP_955834    304 -----LEVNLNMLFEKLLEFMPLPPeeeng----enaanEEPKLQFSYVECLLFSFHQLGKKLPDFLID----------- 363
XP_003385268 308 -----VEICLESLHLFLLEHVPSPPeet---------atESPKLQFSVVECLLFAFHQLVNKSPGFLAS----------- 362
XP_002971368 371 SDRLGEDFTDLYKDFIERqvialLEVAESLSKSTLKKLTQGMTK----VPAAKDENGKAEEkakkvalgVGLRSCNNITK 446
XP_002522525 375 SDRLGEDFSELYKDFTER-----LSNVEELTRATMKKLTQGMAEhnkaMAAAKTDETKDSIkiqkqnttIGLRTCNNILA 449
CBI30644     376 SDRLGEDFSEYYKDFTER-----LTHVEELARATMKKLTQGMAEhnkaMAAAKSDEAKDNIktqkqnttTGLRTCNNILA 450
EFX89475     364 ------DNADRSKDFRSR-----LQYFARGVQGYIKKLRESLQDk--gVDQLRDEEGRIKV--------TALRTTSNINS 422
XP_015787483 369 -----KVNEDRMKDYKLR-----LQYLARLIQSHIKKAKEVPSAd--kKVENEGDDALSKA--------IALKTATNINT 428
Q9V431       368 -----VEDAEKLKDFRAR-----LQYLARGTQGYIKKLEESLKGk--tGEELKTEENQLKQ--------TALKTTSNINI 427 fruit fly
ETN60634     370 -----PDNPAKLKDFRSR-----LQYLARGTQGYIKKLQEAVKGk--tVEEMKSEENQIRV--------TALKTTSNIST 429
EKC39907     365 -----EENAERLKDFKIR-----LQYFARGVQVYIKHLRMALQGk--tGTELKEEENKMKV--------AALKITSNINT 424
NP_955834    364 -----KVSAEKLKDFKIR-----LQYFARGLQVYIRQLRVALQGk--tGDALKTDENKIKV--------VALKITNNINV 423
XP_003385268 363 -----PENEERLKELRKR-----LQYFARGSQTYHNQLQVALKGk--tQLELKEEQNKLRQ--------MALKMTANIST 422
XP_002971368 447 LITPLKQKTPEFl-gGPKNFNPSWKE---AAKPAAAAATatqas-------------apansGAKRPAaa---------- 499
XP_002522525 450 MTKPLHSKTPSFigdKDKSVNLSWKE---AAKPSVASTIta--------------------tGGKRPAnaa--------- 497
CBI30644     451 MTQPLHSKSPSFi--GDKRINLSWKE---ATKPSVPSTAma--------------------aGGKRPAstt--------- 496
EFX89475     423 LIRDLFRNPPSY----KVNVTLSFKP---TNASQAAKQTaavavgne--------stseasgVAKRHApit--------- 478
XP_015787483 429 LVKELFHPKPAS----KSSVTLSWKP---TKTKSAAIKRtnstadttvaptatkledattnaSNPKRKpit--------- 492
Q9V431       428 LIRDLFHSPPIF----KHDIVLSWIVpknNk-------------------------------LGKRHApitfgeka---- 468 fruit fly
ETN60634     430 LIRDLFHTPPSF----KSNVQLSWFVpkgKKQQQKEAEEvk--------------------aGNKRHApitfdangkagk 485
EKC39907     425 MIKDLFHSPPSF----KSVITLSWKPlv--------------------------------vrIKQKRTpi---------- 458
NP_955834    424 LIKDLFHNPPSY----KSTVTLSWKP---VQKTEAAAAi-----------------------GQKRRSgedi-------- 465
XP_003385268 423 LIKDFFRNPPTY----NATVQLSWGA---KKIDLGTKRSlatpl-------------pssnpSKRKLSpirfded----- 477
XP_002971368 500 ------nNGATTKRARGEQhqHQQrqpeqqhLVNKAFAgISRGgGGGgGGRRQWR-------AGRGRGR 555
XP_002522525 498 -----ngSGNIVKKGRGTGgiQNQ-------LVNRALEgISHG-GRG-GSRGRGRgr---gwGGRGRGR 549
CBI30644     497 ----ngaSNAAAKKGRGAGglQNQ-------LVNRALEgLSHG-GRS-GIRGRGRg-----wGGRGRGR 547
EFX89475     479 -----feSSPPKVRVNTDNrvRQPyvvptgkFSANVSA-------HGaDSRPRGRg------GYRG-GR 528
XP_015787483 493 ----apeDSESSD---SKKrqRQLyappsgkFSYNFRG-------GYsNNRGRGRgt----gGFRGANR 543
Q9V431       469 aangkdkDQEPEKKSRPSNd-qKFysppsgkYSNKVNQ------SYGnNNRTRQRgg----gGGGGSGG 526 fruit fly
ETN60634     486 gaatgggDTKGPKQSKPGPgsQKMytppsgkYSGKIHN-NQQSkNGGsGRRGSVGgn----gGGGGGGG 549
EKC39907     459 -----tfETNGAGGKKPHKqdRSIyhppsgkFSEKAGT-FESNeTRSqGQRGRGGgggyrrgGWRGRGR 521
NP_955834    466 ---gataTTKKHPTNLPRRdaRQIynppsgkYSASIGN-------FSyEQRGGFR-------GGRGRGF 517
XP_003385268 478 -kssggaSGGAAKQRGGRReaRAIynpprrqPVTNGNSfDEGSwKTGgGGGGRGGrr----gGWRS-GR 540
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