5ZE6,5JFQ,4LOB,3OYR


Conserved Protein Domain Family
IspA

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COG0142: IspA 
Geranylgeranyl pyrophosphate synthase [Coenzyme transport and metabolism]
Geranylgeranyl pyrophosphate synthase is part of the Pathway/BioSystem: Isoprenoid biosynthesis
Statistics
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PSSM-Id: 439912
Aligned: 911 rows
Threshold Bit Score: 173.87
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5ZE6_A         1 Mnle--------------------------kinELt-AQ---DM-AG--VNAA-ILEQL----N--SD-------V-QLI 32 
WP_079535798  15 Ldeine----------------------cndfiEYi-NA---FS-KE--IGDI-SANSLpngeStiSN---------EYL 55 
NP_866974    289 Mlga-------------------------------tpSEn----gARpaVT----PEQL----Eg-ID-------PiAAT 317
WP_066660853   7 Vrefdeflat--------------vdyesttfgEYl-DH---YA-DQ--VGDL-VNTFIpegtH--PDm------N-RYL 55 
WP_106055504   1 M------------------------------------QE---HL-KK--VSAA-IDKLL----A--ADrypqtirP-DYL 30 
WP_111332096   1 Mrrikdiafrgfs--------rtlkkrrsimdfNAlgQK---YL-DD--INAL-MNGVV----A--ASvv----gG-TSL 54 
WP_082846551 257 Mra-----------------------------sNRmfKEdfpRLlPR--VRSkdpEKT--------KT-------PlAIT 290
WP_013708074   1 MaigqprglrhriaslsrllatqkavpvstsfaDFl-AA---EH-QD--LERR-IADFFcdrtDr-ADi------D-AYL 64 
WP_022740639   1 Mkniseilas--------------veetpvtfeDYl-KA---YA-DP--VGEL-INSYIphgtH--GDm------D-RYL 49 
WP_077024964 258 Mra-----------------------------sSKmfEVdfdRLlPR--VRTkngDSAN-------SS-------PvAFT 292
5ZE6_A        33 NQLGYYiVSGGGKRIRPMIAVLAARAV-GY--------E-----GNAHVTIAALIEFIHTATLLHDDVVDESDMRRGKAT 98 
WP_079535798  56 FDPLSDfFSNPGKCSRSLCCLLANFAC-DG--------K-----VIDCIRPAVAIEIFQNGALIHDDIADHALTRRNKPC 121
NP_866974    318 ETIALDfLARGGKHSRPFITLAAYDAMmGGdgtgadgeDvlnrvPDAVRRAALSIETFHKASLVHDDIEDGDAFRYGQPA 397
WP_066660853  56 YGPLSRySENGGKRHRPLICFAACRAV-GG--------D-----VKRAVSAAAAIEHFHTAALIHDDIADEAELRRGVPC 121
WP_106055504  31 RAAVLDyPQNGGKRLRPAILIWCCRLL-GG--------R-----ESAALYPAAAAEVCHNWTLVHDDIIDQDTTRRNRPT 96 
WP_111332096  55 EAMYHYhMSTGGKRLRALLPLAVAQAL-SV--------P-----PERLLPWGAACEMLHNATLVHDDVQDGDRLRRGQPT 120
WP_082846551 291 EDVAYDwLANGGKRFRPFITLAAFHAR-SSgai--lrtDvehpvSDSVARVAMAIEAFHKASLVHDDIQDNDLYRYGRET 367
WP_013708074  65 YAPLARfSRNGGKRHRPLICMLAARAV-GG--------D-----AAAALDVATAIEHFQSAALIHDDIADRGNTRRGAPC 130
WP_022740639  50 YDPLYHySENAGKRHRPLICFAACLAV-GG--------N-----PDRAATAAAAIEHFHSAALIHDDIADEAELRRGEPC 115
WP_077024964 293 ESISYDwLQNGGKRFRPFITLASWYAA-SGdail-tagDatpeiPDDVARVAMAIEAFHKASLVHDDIQDNDEFRYGRET 370
5ZE6_A        99 ANA------------------AFGNAASVLVGDFIYTRAFQMMTSl------gS-----LKVLEVMSEAV-NVIAEGEVL 148
WP_079535798 122 MHV------------------TNGTEIALNAGDFALTFMDEFVLNdel---ldSsk--kLEVMLELAKMK-TKTIEGQAI 177
NP_866974    398 VHQ------------------RFGTATAINVGDYLIGLGYRLLSRnmmgddvdAgt--rVDLLDSLAAAH-VRLSEGQGA 456
WP_066660853 122 LHL------------------TEGMGLAINAGDLGLTLVNGTVAFdpn---ldDst--kIRLITELTEMT-RRTIEGQAL 177
WP_106055504  97 CHValaggsrsrfglaaaeadRTGRDFAILTGDIQQGWANDLLLRateh-gvpAkv--tVGVMRRFQELAnRELICGEAL 173
WP_111332096 121 VWA------------------KYGTPRAINLGDAMLYWAPLLLMSm------dAavekrEALIKRLLRQS-LLIMDGQER 175
WP_082846551 368 VHR------------------TMGIGPAINVGDYLIGLGYRLVNScrg--dlgAdv--aCDILDSMATAH-IRLCDGQGA 424
WP_013708074 131 LHV------------------TEGEGIAINCGDLELISMTAAVLDdan---lgDel--kIRLLRELVEMT-RRTIEGQAL 186
WP_022740639 116 LHL------------------TEGLGLAINMGDLALSMVNGPVVNdpl---leDav--kVRVIKELIAMT-CRTVEGQAL 171
WP_077024964 371 LHR------------------EHGTGQAINIGDHLIGLGYRLIHSarg---idAdi--aMDVADRMSTAH-IRLCDGQGA 426
5ZE6_A       149 QLMNVND--PDITEENYMRVIYSKTARL-FEAAAQCSGILAGCTPE----EEKGLQDYGRYLGTAFQLIDDLLDYNADGE 221
WP_079535798 178 DIGWEKAceFDQSEENYETMATLKTANYtCASPFAIGATVANASHE----VVRNLRSAGLKCGLAFQIQDDILNVDKSAK 253
NP_866974    457 ELLWRDAkdRRLTPLDALKIYALKTSPA-FEAALYSGVRMAGDASA----LIDPIRKFSRNLGVAFQIINDLNDWAGDDS 531
WP_066660853 178 DIGWARDgrYDITPEDYLVMATHKTAHYsGAVPLAIGAIVGGGSEA----EIEGLRNYGLDTGLAFQIQDDLLNLIGSEE 253
WP_106055504 174 DVEFSLRmlESIGLDEVREMLRGKTGAL-LRFCAEAGAMIAlETDDpetpEVRKLGEFALAAGNAFQLRDDYLGIFGNFE 252
WP_111332096 176 EFLLKDV--ESPSMDAYFKMVEGKTGGL-FMLTLAGAAEFCDAPAK----AVADFETAAAHLGVLFQVQDDVLDLYADKG 248
WP_082846551 425 EMAWQRNpdWTLSPLDALQIYALKTSPA-FEAALYAGLRMAGPMEP----YAEMVSQFCRQVGVGFQILNDLKDWAGDKD 499
WP_013708074 187 DLGWARDarYDLTVEDYLDMATRKTAWYsGAVPLACGAIAGGGCEV----QVEGLRSFGLACGLAFQIQDDLINLq-PLD 261
WP_022740639 172 DLGWARDgrYDITPEDYLTMAIHKTAHYsGAVPLAVGAIVGGADDE----IVEALRSYGLDTGLAFQIQDDLLNLVGTDE 247
WP_077024964 427 EMSFQQSpnWDITPLDALQIYSLKTSPA-FDAALYAGLRMAKHPLA----SGDEVANFCRHVGVGFQILNDLKDWQGDKD 501
5ZE6_A       222 QLGKNVGDDLNEGKPTLPLLHAMHHGTPEQAQMIRtaie----qgnGR-HLLEPVLEAMNACGSLEWTRQRAEEEADKAI 296
WP_079535798 254 DKSKDFALDIAEGKHTLIALHALKTLNETESNELRsill---nknnNE-EDLARALNLIEQSNAIEYAKQRTEKLITEAK 329
NP_866974    532 -NKLTAGADVIGGRPTLLWALALQHLDDEDKQTLLalaep--dcelSDrERLTTVRRLYEKANVFEMSLQLIDKHQARAE 608
WP_066660853 254 STKKDFRNDITEGKRTLCVVHALQNSP--KRDRLVeils---shekDP-AILEEAAQIMQDSGSIDYARAYAENLTSIAK 327
WP_106055504 253 MLGKSLGGDLREGKATILLLSTLQMASAADRNRLLrmlg---hreyTP-HDLETVRRIMVDSGAAGVLEREEAELADRAK 328
WP_111332096 249 RLQR--GADIFEGKISVLVVHFLANAPQAERAWLRrllna-preqiGP-DDIAKVARAFRERGSLDFAVSEIARRHRLAL 324
WP_082846551 500 -NKLVAGQDALALRPTVLLALAMQSATPEQRKEVAsilqs----dgdslARLSRLRRIFSATGAFEKAQSLIEKSRERAE 574
WP_013708074 262 GGGKDVRSDITQGKRTLICVHALLD--DAYHDELVdile---sastDP-AVLERAVEIFRQTNSIAFASERAVELIAHAK 335
WP_022740639 248 AKKKDFRSDITEGKRTLVVVHALQNAAPEARERLVeils---skerDP-EVLAEAVAIMEETGSIDYARTFAEDLTLNAK 323
WP_077024964 502 -NKLRSGQDALALRPTLLLALALKDADEQQRQTLQdvlsgkfddvpEE-ARIDKLRAIFNSCGVFDKAETLVERSQERAE 579
5ZE6_A       297 AA-L-QV-L-Pd-TPWREALIGLAHIAVQRDR 323
WP_079535798 330 GI-I-ST-S-LkdGQGKALLMSMADWCLERTH 357
NP_866974    609 QV-A-DE-I-En-ESLRRLLYFLVDTVLERPE 635
WP_066660853 328 NR-L-LEiL-Gp-SSARDLLISMADWFVNRLN 355
WP_106055504 329 SI-L-KE-F-Pa-NVYRKCLLELVDYLIEREK 355
WP_111332096 325 KSgVfDD-Y-P-------ALSMLLNAVVDRFV 347
WP_082846551 575 AL-A-DA-TeP--VALRQLLYFFIDTVLAPET 601
WP_013708074 336 RA-L-AG-I-EldAECRRLFISMADFFIERVS 363
WP_022740639 324 AR-L-AGaL-Pp-SQYRDLLVSMADWFVNRLK 351
WP_077024964 580 AI-V-ED-I-Ed-EKVQALLRFFLETVLARDD 606
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