This family includes the yeast Malassezia sympodialis allergen Mala s 1 which is localized in the cell wall and exposed on the cell surface. It can elicit specific IgE and T-cell activity in patients with atopic eczema (AE), a chronic inflammatory disease. Mala s 1 does not show any significant sequence homology to characterized proteins. However, its structure is a beta-propeller which is a novel fold among allergens.
Comment:based on the active sites of beta-propeller folded proteins where they are normally localized within the center of the N-terminal cup, spanned by connecting 4-1 and 2-3 loops whose residues often take part in substrate recognition or catalysis
Jiyao W et al.(2023). "The conserved domain database in 2023.",