5OQL,7MQ8


Conserved Protein Domain Family
Utp14

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pfam04615: Utp14 
Utp14 protein
This protein is found to be part of a large ribonucleoprotein complex containing the U3 snoRNA. Depletion of the Utp proteins impedes production of the 18S rRNA, indicating that they are part of the active pre-rRNA processing complex. This large RNP complex has been termed the small subunit (SSU) processome.
Statistics
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PSSM-Id: 461368
Aligned: 136 rows
Threshold Bit Score: 299.251
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5OQL_K        231 DALQSMIAGFAGE---DE--ES----GGEGEAKPSGK--------------QKLSLKDLGLVGv---kDPDMKRSLRLMK 284 
XP_014310689   63 QKLLEAISSLDGK----N--RR----KLAERSEASLKvseftv--sskgsgERLVLSDLLEPVktsssLATVKKQLNRV- 129 
XP_001944030   24 RKLLQTITSKTKr-------KI----QPSTRNEPSLQvsefh----lssgqQTTNVDDLTNALkk--kAPQIRQKIQVAK 86  
Q7PH75         13 AKLIDGINALTGS----H--YI----REVTRTEPSLKrsefgl---sktkdDKVRLGDLAKFFtktkkHISVAKQLDQL- 78   Anopheles gam...
EFA08495       22 DKLVQKVLSLNKT----Q--QL----KKPSRTEPTLQisefnlvksitghkGAVHLNDLAKTLksrksRLKISENVKKIQ 91  
Q4Q5S1        176 QARVKKATRMTES---GTkvAK----KRRASQLTDEPesvfgla-dasasgGTTSYTGAMQRImq-qrETSTDHDMDAVR 246  Leishmania major
EGG23177      273 EKMLELMEGLDTT---QLkkLS----NLPDVTEMFSKesqhgv---rptndDQLDLGDLLEMMpe--eFDQLKTQLQGVA 340 
XP_003293460  205 SNLLSIVKNLEKNqprKS--TK----KLADMTESVGSeslfgmf-ptadenGTIDINDLMSFMpn--eFEQFKQQIEDI- 274 
7MQ8_SS        44 QKLLEAISSLDG----KN--RR----KLAERSEASLKvsefnv--ssegsgEKLVLADLLEPVktsssLATVKKQLSRV- 110 
XP_007659906   40 QKLLEAISSLDGk-------TTsfrrRLTERSEASLQvsefsv--sskgtgEKLALSDLLGPIkpsssLAPVKNQLNRI- 109  platypus
5OQL_K        285 KEekatkpGSSKKLEVPLAKRQQDRLMREAAYKKTNETLDRWIETVKHNRRAEHLVF-PLAQn-AHDRgldASELQPI-T 361 
XP_014310689  130 --------ISKKTVELPLNKEEVERIHREVAFNKTSQALSKWDPIVQKNRQAEQLVF-PLIK--EQSA---FAPMEHVlN 195 
XP_001944030   87 --------STKKLLQKPLDKVHADKIKRAVAYDNFKKHISRWSAVIEKNKSADQLRF-PLRSseVEVF---DNRMVDFtR 154 
Q7PH75         79 --------KVRNPLQKPLEKPVADRIERKAGFERVRKDVDRWEPIVTAQQVAPQTVY-PLQYd-STTV---HDAPPKRlS 145  Anopheles gam...
EFA08495       92 --------RHSRTLPKPLKKPQANRIRRSVAYEKTRLELDRWEATVTANRVATNLSF-PLDNd-YKLE---KKENKNFtS 158 
Q4Q5S1        247 DRikrshqSKRNLVAVDVDDLTKDRLTRKEVRAIVDETMERYTPVLKELDSAKHIQF-PMHLpdSTPV---ASSVGGIvA 322  Leishmania major
EGG23177      341 --------SGGGALSKPLNHIDQAKLSRKIATQDVEKSLAKWDRFIRHQRELATVVYkR-----RVET---VNDVSVLgT 404 
XP_003293460  275 --------ADKSAISAPLSKFEKDKIQRRITTEQAHKILTQWVPFVREQR-DKNLKFdS-----KVVV---ANTSQSLaN 337 
7MQ8_SS       111 --------KSKKTVELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVF-PLEK--EEPA---IAPIEHVlS 176 
XP_007659906  110 --------KSEKTVKVPLSKEKTEQIRREVAYNKTSKDITKWDPIVWKNRRAEQLVF-PLNQ--EHLV---ITPIEETiD 175  platypus
5OQL_K        362 QKTSGTELEQTILAIMEESG-Lgp----------taKPEKKETSGE----AG-KQGMSKEEQKELIRQ------------ 413 
XP_014310689  196 AWKARTPLEQEIFNLLCKNKqPv-------------TDPLLTPVEK----AS-LKAMSLEMAKMRRAE------------ 245 
XP_001944030  155 GFSHPTDLQKKISAVLQSSKiVqqkq-------kdlKMSWIEKEKE-------KYPLTLKELLEKRKS------------ 208 
Q7PH75        146 EYRVKTKLMEELEELEKAYD-----------------ESGEDGDEHsddgKQ-NYALTIEEMREQQYE------------ 195  Anopheles gam...
EFA08495      159 MWRVKSALQQELEKIEPTVE-----------------EYHIDLEKE-------KFPLTMKEMLVRRQE------------ 202 
Q4Q5S1        323 AADAQFRSDRAVTPALSNSS-AyrfgskmdallskaGLSRRQVGDGadtpNSmGNYVKFDDVVADGAQrqgmedgeapss 401  Leishmania major
EGG23177      405 ATQ-ATDLNRLIGSALKKDG-Lp-------------NNMAVNAAGSggdkKK-KTKKELHEDKERLNE------------ 456 
XP_003293460  338 SFQ-KSDLNDEINRALQESGaVqk----------------------------lKQEVDPIEAKRQLRE------------ 376 
7MQ8_SS       177 GWKARTPLEQEIFNLLHKNKqPv-------------TDPLLTPVEK----AS-LRAMSLEEAKMRRAE------------ 226 
XP_007659906  176 SWKPRTPLEQEIFSVLNQHKqPk-------------TDPLLTPMEK----AS-FKAMSLEEAMLRRAE------------ 225  platypus
5OQL_K        414 --KRRERELHSREMARLKRIKKIKSKTWRRIHRKELLKNEEaayqa----aleaGEL-DSeeEREALDRRRALERVGARH 486 
XP_014310689  246 --LQRARTLQSYYEARARREKKIKSKKYHRVLKKGKAKNSLkefeklrktnpaaALE-----ELEKLEKARMMERMSLKH 318 
XP_001944030  209 --MANFRAKESYRHAKAHRQNKIKSKKYHRLLRKEKTKEQIkefeklqdtdpvaALE-----KLNVIEKTRAEERASLRH 281 
Q7PH75        196 --RSRQKIRESYAIAKNRRMNKIKSKKYHRLLKKDKLKEQMqkfeelkekdpeeALR-----KLDWIEKQRSQERISLRH 268  Anopheles gam...
EFA08495      203 --AAKLRAYQGYREAKARRQRKIKSKKYHRIQKREKIKKQLkefellqktnpeeALK-----KLEEIEKTRIEERFSLRH 275 
Q4Q5S1        402 gyVAKLKAMLAYENSRRKRLNRIKSKTYRRILRKEKDREKErrqkafellhpelARQrLA----ERLLKARIEERVTQKH 477  Leishmania major
EGG23177      457 --IIALRNKMYYEAQKNKRQSKIKSKTYRKILKKQRIKEMEkrdeelskldpeyARH-----KQLAAEEARIVERMNQRH 529 
XP_003293460  377 --TIKLRNIMYYQELKDKRRKKIKSKKYRKILKKEKEREAKkledrlkeldpdfAKK-----LAEKAEEKRILERMTMKH 449 
7MQ8_SS       227 --LQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALkefeqlrkvnpaaALE-----ELEKIEKARMMERMSLKH 299 
XP_007659906  226 --MQKARALQSYYEARASREKKIKSKNFHKMLRKGKAKEALkkfealrksdpvaALE-----ELEKIEKARMQERMSLKH 298  platypus
5OQL_K        487 KE-SKWAKLGKKAGRAVwDEDFRAGLAEMARRKDELRKRIEGLkng---sdDSSD----------DSDGDEDASGDeaa- 551 
XP_014310689  319 QNsGKWAKSKA--VMAKyDLEARQAMQDQLARNKELTQKVQVAseseeeegGEEEvdl----lvpDAVNEAHMTADgpnp 392 
XP_001944030  282 KStGQWARNHV--VRAKyDKDSRIALAEQLRKSKELTQKVQPSlnetndsdSSDE----------EQIEISEQVVDpdnp 349 
Q7PH75        269 KNtGTWAKNLQ--VRAKyDTEVRRELAEQLAIGRELTAKRlqqg----dssSESD----------GEMDLSMGQAGetnp 332  Anopheles gam...
EFA08495      276 KStGKWARNQQ--VRAKyDKESRQVLAQQLTLSRELTQKLknnn---sdsdEDEA----------KEEEKVPEVIDkdnp 340 
Q4Q5S1        478 KNtSAWVKHAKRF--AQfDENTKDAIDDQHATHQRLMQKMeq--------dAGEEnyer---yvaGDNESEASSEEertv 544  Leishmania major
EGG23177      530 TNkSKFMKNVLKGGL---NLERRQAINEQHQTHLELKNKMKSVrqefsdsdASDD----------DDTPSSNNKDEqmyk 596 
XP_003293460  450 KNhSKFMGQLIKGGL---NKEKRQDMNEQRKLADEIMAK-ANRfndsededDSDD----------SEEYDSEDEQEtnsk 515 
7MQ8_SS       300 QNsGKWAKS--KAIMAKyDLEARQAMQEQLSKNKELTQKLQVAses---eeEEGGtedveellvpDVVNEVQMNADgpnp 374 
XP_007659906  299 QNsGKWARSKA--IMAKyDLEARKAMQEQLAKNKELTVKVQKApdseeeeqEPEE----------DSNLIPEMVNEvqms 366  platypus
5OQL_K        552 --------------------------------------------erRKLLAELEKAAAYS------------DDDE--P- 572 
XP_014310689  393 wmv-------------------------------------rnhsddAKEAEIQKDSE-QLpepmaneaseseEEERpvA- 433 
XP_001944030  350 wlaerkefkdfmvgy------------nnfvqnncetkdtndqyinNNKNEETKESEESN------------VNEVkhD- 404 
Q7PH75        333 wteragdyeqvankem-----------qqtgsyrkyweernqveniKKHLNGDGKTANGQqangrlssdedeNELSdgD- 400  Anopheles gam...
EFA08495      341 wvngikpgkdvadfisgyrkywmeknkegetgqlqedaqenvtvseEIQMENNKQLEEEAstidegyrveknKDEEekT- 419 
Q4Q5S1        545 daliekvga-------------------------sggaplsrqdvkSILWSSVDAVETDEnaaa-----rtmTSPIsrA- 593  Leishmania major
EGG23177      597 svd------------------------------------rdiserdVEDLDTTLPIKERIqqklgl-lgmnpNAKEivS- 638 
XP_003293460  516 skgs----------------------------------kidlsevdQQALSD----KERIqlklq-----klgkpTnlP- 551 
7MQ8_SS       375 wmlrsct----------------------------sdtkeaatqedPEQLPELEAHGVSE------------SEGEerPv 414 
XP_007659906  367 id--------------------------------------gpnpwmQRTLSK---DTKDAa-----------VPEEpkP- 393  platypus
5OQL_K        573 -HSKL-----FQLKFMQRGEELRR-------------KENEELIAQI---RRELDSDYDGSEPDEv-------------- 616 
XP_014310689  434 -EEEI-----LLKEFKESQLLRKM---------------------------SGLNQDTKPVGRQEtedsstqevl----- 475 
XP_001944030  405 -KTAI-----PIVKIKKKNQNKVKnitiqdlsifdeeESFVEGLKIVspkKKKVHFSDDTIKPETkineidtnikinsta 478 
Q7PH75        401 -EGVQpskpkRAKTLTKKRKEKVKmasgtwivedvdnSDQKRKKKDSaktKKNRKTKDNVATVEAmfqeaeelikdvld- 478  Anopheles gam...
EFA08495      420 -EQSQedspeATLTISEEKVTKKK---------------KQSKVGKKknsTEDLKQSKSTSDWEIsvvdnatdved---- 479 
Q4Q5S1        594 -RTEL-----REMKFMKNAREREE-------------KDYEDQLEAL---RRDIEAHHREECAGSetqgeeaedgtgpt- 650  Leishmania major
EGG23177      639 -DKGI-----NALKFMQNSVERDL----------------DQQIQRKihgNDDYDAMEAQEKKKQqidkeysghiaihrp 696 
XP_003293460  552 -EKGI-----NAMKFMQKALERDL----------------DDSIKKMn-gVDDYEQNEIDEQEKLieqsnriaihkqv-- 606 
7MQ8_SS       415 aEEEI-----LLREFEERRSLRKR-------------SE-------L---SQDAEPAGSQETKDSgsqevl--------- 457 
XP_007659906  394 -PAQT-----PTPAPALEESESEE-------------EEPGAEVESL---LREFQQKRSHRQSVAskkarekgvkd---- 447  platypus
5OQL_K        617 --------------eIGR------RTF--------------------------GMGKKDKTEQQQAQDQLARMQAAEARK 650 
XP_014310689  476 -----------------------------------------------sklrglsqklNKDNHQCRKQNMGSVRTVLSTQR 508 
XP_001944030  479 lcnkknnninvintvAGTwfvtsdNINddivnkkkvhkdvenafktvetelknKINEKLLNLNKTKVKQPSKTDIAKRRN 558 
Q7PH75        479 ---------------------------------------nklefvrnidhgksSDTNGPSSKLPDQQDKETKLSDLSFKK 519  Anopheles gam...
EFA08495      480 ------------------------------------------mfnklekklqrTMLKRVKKLKHKINKEDKTKTEPKRKK 517 
Q4Q5S1        651 --rktsssaaqpsaaAGR------VTF--------------------------KKGKKSGSVERIQLRRQSGICIEANDH 696  Leishmania major
EGG23177      697 vakqqqqsqttksdtTGQlv--dkVAF--------------------------SSGHKMKTSTSISVGQAASVDIENVKS 748 
XP_003293460  607 ---asnkqssnkimsTGQlv--ekAGF--------------------------GSGHKVKSGVSIDIL------GKQQQQ 649 
7MQ8_SS       458 ---------selrvlS---------------------------------------QKLKENHQSRKQKASSEGTIPQVQ- 488 
XP_007659906  448 -----pfrgeekevlAHL------KVF--------------------------SQKI------GSQQAKVAKKQQAPAPQ 484  platypus
5OQL_K        651 EKAAARVAAAEETVkqeAREKAEKDEASAp---STAGAwSQPKVEAGAWSKPd----dE--GSSKPRKapkgrpEEIDVT 721 
XP_014310689  509 EGPAG--------------------------------------EEEEPLLLQrperaqTleELKELSK------EGCFQN 544 
XP_001944030  559 EEVKSDYL-----------------------------------------------------KMNNKRI------KAEFNE 579 
Q7PH75        520 RATLADAD------------------------------------------------------EQMYET------AERAAP 539  Anopheles gam...
EFA08495      518 VDNKVDLT-------------------------------------------------------LNPQK------KIPIID 536 
Q4Q5S1        697 GAESSRDES--------------EGVELGs--vVSASS-AEDGGKPSPV----------------------------AAR 731  Leishmania major
EGG23177      749 SDITASTNKKVADYv-kIKIDENDKKKRKh--vEDEQE-EEESADSNPWIN---------------------------GT 797 
XP_003293460  650 QDEEIKKV---------------NNKKQQenqeEEEQV-EEELDEENPWLE----------------------------- 684 
7MQ8_SS       489 ---------------------------REe---PAPEE-EEPLLLQRPERVQt----lE--ELEELGK------EECFQN 525 
XP_007659906  485 AVAAPEET---------------------------------VQCEEGPLLDErl-----drVQRLEDM------DRLGSE 520  platypus
5OQL_K        722 DLALAGKPAKAKANGQ-AKSQVQGKAHASN-----GQSSSSQKAstsVAIT----------------------------- 766 
XP_014310689  545 EELPRPALEG----QQ-VERN--NQPSAPKkk-rkEQMIDLQNI---LTTKspsmks----------------------- 590 
XP_001944030  580 PLYENNRTLDTNNISN-VENNTGSAIKIVGkptkqVQNIDPTEF---LQVTqislete---------------------- 633 
Q7PH75        540 DETNNASSLLKNIQSS-NDKSSTVAGGRPSpsvkqSAEINLKQV---VQMKpkhlltal--------------------p 595  Anopheles gam...
EFA08495      537 EELIENTNSDAENSQN-NETLSNLKNISTKevaqnESNIDPDKY---MKVKptnlsta---------------------- 590 
Q4Q5S1        732 DTGGRLKAQGPAKEKT-KRATPSALPASEFagarkDAPLERGLP---VNKAtstrvtilpkkrarpgedaaaeesapsas 807  Leishmania major
EGG23177      798 ERSQAGTGSKEKKKKI-LKKPKKNSNNNKNskknqSMSLIT--------------------------------------- 837 
XP_003293460  685 -----VTKTKKKSKKE-KKKQSTEFLISLNnlnnnSSNKNLGSN---NSKEkvkngdlpismdtt--------ekdnsnn 747 
7MQ8_SS       526 KELPRPVLEGQQSERTpNNRPDAPKEKKKK-----EQMIDLQNL---LTTQ----------------------------- 568 
XP_007659906  521 ERVEEEPLLRPPPGEG-GQGQGPRPPAGVQppgkkQKIISLKAM---LAVKsqpvesl---------------------- 574  platypus
5OQL_K        767 ------G-AEEDGNdsd---dsdAvh--lpMAIRDrALIERAFAGDDVAAEFEKEKAEIEADDDEKEIDN--TLPGWGSW 832 
XP_014310689  591 savptiE-ELEDEQ-----------------ERKQkQMIKEAFAGDDVIRDFLKEKRETVEASKPNDVDL--TLPGWGEW 650 
XP_001944030  634 emaqveD-HLDDKE-----------------ENEQeKLIAEAFADDDIINEFKEEKKKLEEQSKPKIESA---LPGWGSW 692 
Q7PH75        596 ntivsgE-LSDDEAe---------------aDDAHrLTIAEAFEDDDIVADFAKEKQDERQKDLPQQVEL--SLPGWGHW 657  Anopheles gam...
EFA08495      591 ----ipdiltEDNE-----------------EPTQrEIISEAFEDDDIVQEFAKEKQDEVDRDKPKDIDL--SLPGWGSW 647 
Q4Q5S1        808 tlvdsaS-VPEEDL-----------------RLNQeYLLSRAFAQDDVDEDFVKEKESQV-ETIMRPEDKnqSLPGWGEW 868  Leishmania major
EGG23177      838 -------------------------------SKKQkDLLKKAFENDGVQEEFEQEKDELIENAVAPTQDA--SLPGWGSW 884 
XP_003293460  748 nnssnkR-KLEDKEdnenkkskkSvgmsliTSNKQkDLLLEAFAQDNIEDEFMDEKKQILEEDVPEEKSN--FLPGWGSW 824 
7MQ8_SS       569 ------S-PSVKSLavp---tieEle--deEERNHrQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVDL--TLPGWGEW 634 
XP_007659906  575 aapimvQeEEETGE-----------------EGTQrQMIREAFAGDDVVADFLKEKHQAEEADKPQTVDL--TLPGWGEW 635  platypus
5OQL_K        833 VGEGVSNr--eKRRHqg-rFVTKV-EGI--KKe------kRKDYKLKDVIINEKRVK--KN-DKYLATGLPHPFESQQQY 897 
XP_014310689  651 GGVGLKPs--aKKRRr---FLIKA------PEgp-----pRKDKNLPNVIINEKRNI--HA-AAHQVRVLPYPFTHHQQF 711 
XP_001944030  693 AGPNIRKrtfkKRTNmgm---------frtPAkp-----pRKDFNREKVIIHESADD--SI-KSHLVSELPYPFKGIEEY 755 
Q7PH75        658 AGAGAKPpgprKATR----QIMKM------PAel-----pRRDDNRDQVIINEDALKneKL-DKHLVNEVPFPFVTVKDY 721  Anopheles gam...
EFA08495      648 GGTNIKVn--kRKKRr---FTIKA------PPkv-----pRRDDNKGTLIINEKAQN--KI-KEHMVSEVPFPFKTVKDF 708 
Q4Q5S1        869 GGEDPELnkrhQEAVlhqttqRQIeKSFllKS--------RADAALEHVIINHDGVE--LVpNRMTLHMVPRPFSNPQEF 938  Leishmania major
EGG23177      885 AGDGVKQsk--------feIQKRKkQKIqrDAqvkdlaskRTDITNNKVIIDDAALK--GGiGKYMINNIPRHYVNKEQY 954 
XP_003293460  825 VGDGAKQrdnsKRDA----ALKRKr-----QEklkeaakrRLDAQNSRVIIDEKAPL--EGaSKYILNKLPQHYSNKEQY 893 
7MQ8_SS       635 GGVGLKPs--aKKRRr---FLIKA-PEG--Pp--------RKDKNLPNVIINEKRNI--HA-AAHQVRVLPYPFTHHWQF 695 
XP_007659906  636 GGVGLKPs--qKKKRr---FLIKP------PEgs-----sRKDQHLPNVIINEKRNV--RA-AAHQVNQLPFPFSHHQQF 696  platypus
5OQL_K        898 ERSLRLPVGPEWMTKETFQDATKPRVIIKQG-IIAPMSKP 936 
XP_014310689  712 ERTIQTPIGSTWNTQRASQKLTTPKVVTKPGhIIKPIKAE 751 
XP_001944030  756 EETIKAPVGRTWVPETVFQKLTAPPVVTQMGqIIDPIDEN 795 
Q7PH75        722 EASLRAPLGRTFIPESAHAAMVEPRIVTKQGtVIEPMKKE 761  Anopheles gambiae str. PEST
EFA08495      709 EASMRAPISNTFVPETAYRRLIKPAVTTKMGtIIEPISKD 748 
Q4Q5S1        939 ARSMRQPMGPEWTSALTFKEGVQPRVEVRQGqSLLPLDLS 978  Leishmania major
EGG23177      955 ENTLETPIGPDWNTYSAFKKLIEPKLRVEAGvTIQPVGTK 994 
XP_003293460  894 ESTLSIAHGKDWNSTTAFRKLIEPKVSVLPGtFINPVSNK 933 
7MQ8_SS       696 ERTIQTPIGSTWNTQRAFQKLTTPKVVTKPGhIINPIKAE 735 
XP_007659906  697 EKTIQTPVGTTWNTQRAFQKLTAPRVVTKQGhIIEPISAE 736  platypus
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