1LQA


Conserved Protein Domain Family
AKR_Tas-like

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cd19094: AKR_Tas-like 
Click on image for an interactive view with Cn3D
Escherichia coli Tas protein and similar proteins
Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Statistics
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PSSM-Id: 381320
Aligned: 38 rows
Threshold Bit Score: 393.469
Created: 13-Mar-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitecatalytic
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1LQA; Escherichia coli Tas protein in complex with cofactor NADPH, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ###    #                          #    #                                  
1LQA_A     13 VSTLGLGTMTFGEQNs----EADAHAQLDYAVAQ-GINLIDVAEMYPvppr--petqGLTETYVGNWLAKHg-----sRE 80  Escherichia coli
CAL55523   61 VSEIGLGTQRWGSADvnapdETLCHAMMDRAVLErGVSLIDTAEQYPipsdr-srpeGRTEEIIGRWLAQDks----rRE 135 Ostreococcus tauri
EFN51689   32 CVPSLQGTMTFGEQNs----EEEAWEQLDYAVGQ-GVNFIDTAELYPvpps--petcGRTEEIVGRWMAARg-----cRD 99  Chlorella variabilis
CAJ20544  249 VSQVGLGTMTVGSPQl---gRERAFELFDYAVDEwGVNFFDTAELYPlpas--pvtyGRSEEILGAWLARRgr---geRE 320 Toxoplasma gondii RH
OUU27415    3 SKTLWYGCQLLGSQIn----KRTSSDILDLCLDN-NVLHFDLAERYPfpeq--ketvGESEKIFGTWVKRKe------RE 69  Alphaproteobacteri...
ADE55672   13 VSEICLGTMTMGSQLn----ERSSFEILDYAYEQ-GIDFYDTAEIYPvppe--tkwvHRTEEIVGKWLQTKd------RD 79  Coraliomargarita a...
ETW29337  441 VSEICLGTMNFGNYVn----EKLAHELFDYAFEEfQVNFFDTAEIYPlpas--enyyGHSEEILGNWLEAKgk---anRH 511 Plasmodium falcipa...
OUU75020   13 VSELALGSINFGGKIt----TSSATKILDIVYEK-GVNLIDTSEVYPmpfs--esgyGKTEKIIGKWLQGNn------RD 79  Gammaproteobacteri...
CEM02840  125 VSEVCLGTSHIGQEHli--dSGDAIEQLDVAVDEyGINFLDMGDNEPvpsr--pqfkGKGHELIGKWIKDKgga--afRE 198 Vitrella brassicaf...
EED91947  118 VSELGLGTQRWVSADfnapnKDQVFDFMDTAILKnGVNLIDTAEQYPipsdgkvakeGDSEIVIGEWMRTRgldkgegRR 197 Thalassiosira pseu...
Feature 1           #                                                                         
1LQA_A     81 KLIIASKVSGPsrnndkg-------------------------------------------------------------- 98  Escherichia coli
CAL55523  136 KVVIATKITGGs-------------------------------------------------------------------- 147 Ostreococcus tauri
EFN51689  100 KVLLATKVMGGskvrr---------------------------------------------------------------- 115 Chlorella variabilis
CAJ20544  321 KFVVATKVAGRredqe---------------------------------------------------------------- 336 Toxoplasma gondii RH
OUU27415   70 KIHIGTKVTGRnsegwf--------------------------------------------------------------- 86  Alphaproteobacteri...
ADE55672   80 SIVLATKVVGPghgwfqpp------------------------------------------------------------- 98  Coraliomargarita a...
ETW29337  512 KFVIATKICGRtdklpwmkkykirteqknilnkrnadiyndnnykkdhyitnsksneyshrnnnhmldkednkngydklk 591 Plasmodium falcipa...
OUU75020   80 SIIISTKAAGPgefikwi-------------------------------------------------------------- 97  Gammaproteobacteri...
CEM02840  199 RLVLSGRIATSetlvrqphppaq--------------------------------------------------------- 221 Vitrella brassicaf...
EED91947  198 KVVIASKITGGr-------------------------------------------------------------------- 209 Thalassiosira pseu...
Feature 1                                                                    #                
1LQA_A     99 ------------------------------irpdqaLDRKNIREALHDSLKRLqTDYLDLYQVHWPQRptncfgklgy-- 146 Escherichia coli
CAL55523  148 -----------------------------------nVNAKNIQRDLERSLLRMkTDYVDVYTLHWPARytpqsnwgqsln 192 Ostreococcus tauri
EFN51689  116 --------------------------------rgagVGPAQIVAAVEGSLRRLqTHYVDLLQLHWPDRyvplwgknqy-- 161 Chlorella variabilis
CAJ20544  337 -------------------------------ttgtcLSKKQILAAAEGSLRRLkTDYVDLFQLHWPERyvplhssgdfgd 385 Toxoplasma gondii RH
OUU27415   87 ------------------------------gedaerLTYNRIRTAVQTSLKRLnTDYIDIFFLHWPDRftnnfgrfyy-- 134 Alphaproteobacteri...
ADE55672   99 -----------------------------vrkgktaLDRHHIRTAVEASLQRLqTDYIDLYQTHWPDHdf---------- 139 Coraliomargarita a...
ETW29337  592 elkekeelylkkdydkinkfeeyekerldnsanlitLNKENIINSVDKCLKRLkTSYIDLLQLHWPDRyypdqssgdfsh 671 Plasmodium falcipa...
OUU75020   98 ------------------------------rngksiHNRENLQSAVEGSLTRLgTDYIDIFWLNWPDRpinssdiffe-- 145 Gammaproteobacteri...
CEM02840  222 -------------------------trqdrkrpgppMTRERIREAVDGFLGRLgTDYLDVVSLSAPDRytpmteegedt- 275 Vitrella brassicaf...
EED91947  210 -----------------------------------nVTPKNIKNDCAGSLKRLgTDYLDVYQLHWPARyspqsnwgqsla 254 Thalassiosira pseu...
Feature 1                                                         ##                         #
1LQA_A    147 --------------------swtdsapavsLLDTLDALAEYQRAGKIRYIGVSNETaFGVMRYLHLADkh-dlPRIVTIQ 205 Escherichia coli
CAL55523  193 yd--------------vemerapyyknaasFEEITEAMGKMIDQGKLRGYGSCNDNaYGLTAMCYAARsv-gaPEPCCMQ 257 Ostreococcus tauri
EFN51689  162 --------------------hasqrydpvpFEEQVAAVGKLIQEGKVRHWGLSNETaYGVCRMCEAATrl-gvPPPISIQ 220 Chlorella variabilis
CAJ20544  386 vlfdpevdegpgarvvpraaeqesreavvpMEEQLEAVGQLLREGKIRAWGLSNETpYGVCRFTELATrffglPPPASVQ 465 Toxoplasma gondii RH
OUU27415  135 --------------------epepdptfitFEEQFSALATAYEKGEIKAIGLANETpWGLMRFLELNRt---vGIKLYIQ 191 Alphaproteobacteri...
ADE55672  140 -----------------------------gYEETLTVLTELVEEGKVRIIGSSNETeWGTMKANEAARal-gtSRYETIQ 189 Coraliomargarita a...
ETW29337  672 v----------------lydynkyyddfipFIEQLQALDELKKKGKIREWGLSNETpFGLLKFYELCKhl-hiSPPVSVQ 734 Plasmodium falcipa...
OUU75020  146 ---------------------eskqqksysIEETSDALLSLVKAGKIRHFGISNETpWGIAQYLKFGG-----EHFIGIQ 199 Gammaproteobacteri...
CEM02840  276 -------------------ycygyehdslsMEATLDAFEELVKEGKVRHIAVSEETpWGLFKFASMAEqr--gLPLVFSQ 334 Vitrella brassicaf...
EED91947  255 ydla-----------tdkapywrgmggptsFEDLCIAMQDLIDEGKIRGWGMCNDNaYGLAGCTRTAKal-gvTPPCSLQ 322 Thalassiosira pseu...
Feature 1                                    #######  # #                                     
1LQA_A    206 NPYSLLNRSFEv--gLAEVSQYE--GVELLAYSCLGFGTLTGKYLnga-------------------------------- 249 Escherichia coli
CAL55523  258 GDYSLINRRSEen-gLAEASSPVheNAGWMGYNLLAGGVLTGKYRkikaavdnpdd--------------------pala 316 Ostreococcus tauri
EFN51689  221 NDFSLLDRRFEs--qLAEACAPHhhNIGLLPYGPLAGGTLTDKYFaggs------------------------------- 267 Chlorella variabilis
CAJ20544  466 VQYNLLCRNDVek-gFVELARPQnaGTALLAYGALGGGILTGKYLewle------------------------------- 513 Toxoplasma gondii RH
OUU27415  192 EPYSLLNRNVDi--aLKEIIIRE--QLAFQVHSIFAGGLLTGKYKlenn------------------------------- 236 Alphaproteobacteri...
ADE55672  190 NNFSINNRRFEd--aLADICTRE--QISLLPYSPIGGGVLSGKYNdgq-------------------------------- 233 Coraliomargarita a...
ETW29337  735 LEYNLLCRNDVek-gFPEICRPQntNISILAYSPLCAGILTGKYLeytd------------------------------- 782 Plasmodium falcipa...
OUU75020  200 NPFNLINRGFEi--sHAEMVAME--NLSLIAYSPLAGGLLGGKREksp-------------------------------- 243 Gammaproteobacteri...
CEM02840  335 HVYNIMNRNHVessgLAEMAGTRqmNVPLVGYSPLAGGFLTAKYLdperwnlkgptfvpqegtfpsfveewqdlqpedwg 414 Vitrella brassicaf...
EED91947  323 GDFSLIDRKSEen-gVAEAASPFneNVGFMAYNALAGGFLTGKYMdrpaaidnter---------------------dkv 380 Thalassiosira pseu...
Feature 1            ###                                           #                #####   # 
1LQA_A    250 ----kpaGARNTLFsr---------ftRYSGEQTQKAVAAYVDIARRHgl-dPAQMALAFVRRQpFVASTLLGATTMDQL 315 Escherichia coli
CAL55523  317 erllknpRGRMDDYswgq------tlyRYRSGPALRAIDAYAALAEEAgi-sLTELALRWAQRRaFMTTALIGHTSLAQL 389 Ostreococcus tauri
EFN51689  268 ---gpgpNSRHFPGfq----------pRYHSAASMAAAAEYAAVAKGAgl-tLAQLALAWCASRwYVASTIIGATTLQQL 333 Chlorella variabilis
CAJ20544  514 ----yptTGRMLRFpsy--------mkRYRGSLAARAVSAYFYLALRLehpnLTVMALRWVLSRpFICSTILGFTDFYQL 581 Toxoplasma gondii RH
OUU27415  237 ---dfagIGRLSTFkh---------qtRKLRQKDIFQRYKLASEFCREnnvsLMEMAFAYVYSKkYIGDIILGASTIEQL 304 Alphaproteobacteri...
ADE55672  234 ----lpeGARFSDYlqtggprqkamaaRFVNEKTLATTAELIALAREIdm-dVVTLAVAWSKQHrYVASTIIGANSIEQL 308 Coraliomargarita a...
ETW29337  783 ----yttKGRMQKFpsy--------mkRLRGSIATYIIRELYYLSQKYyfpnLTVAALKWVYTRsFITSTIIGVSDFVQL 850 Plasmodium falcipa...
OUU75020  244 -----lkRSKRDSFwl----------nQYNSIQNLVHISKLKHIAEESni-kMHALALQFVLSFeWVASTIVGCSTTEQC 307 Gammaproteobacteri...
CEM02840  415 fisygpeTGKLNRYkgw-------yeaYRASVFAHMHLGKLLKTARSHgy-aMWQLALAWCYSRpFMGSTIITPRTLGQL 486 Vitrella brassicaf...
EED91947  381 ieamqnpRGRHDEIgwgr------tlyRYRSEAAQEAILDYSKIAKSAgi-sLTELSLRWCRQRtLVTTTLVGHTDMNQL 453 Thalassiosira pseu...
Feature 1       #                        
1LQA_A    316 KTNIESl-----hLELSEDVLAEIEAV 337 Escherichia coli
CAL55523  390 DETLDYfda--skPPLDDALMWAIDRV 414 Ostreococcus tauri
EFN51689  334 QENIAAf-----eVELDAATLAAVDAV 355 Chlorella variabilis
CAJ20544  582 RENLFCttp--acGALSDWAEREINFL 606 Toxoplasma gondii RH
OUU27415  305 QNIFGAysrkhflTNLTKDLEEKVYPT 331 Alphaproteobacteria bacterium TMED37
ADE55672  309 KPSLAAa-----dLTLPADVLEKIDAI 330 Coraliomargarita akajimensis
ETW29337  851 RENLYSlt---neVLFTDKLEREINAL 874 Plasmodium falciparum FCH/4
OUU75020  308 RQNFINt------SILDKKTLKKINKL 328 Gammaproteobacteria bacterium TMED69
CEM02840  487 RDSIRAl-----nFPITPEIEQDVHEI 508 Vitrella brassicaformis CCMP3155
EED91947  454 KQSIDYft---knDPLPDRIMWEIDRV 477 Thalassiosira pseudonana CCMP1335

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