Conserved Protein Domain Family
EDR2_C

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pfam07059: EDR2_C 
Protein ENHANCED DISEASE RESISTANCE 2, C-terminal
This family represents the C-terminus (approximately 250 residues) of protein ENHANCED DISEASE RESISTANCE 2 (EDR2) from plants. EDR2 is a negative regulator of the salicylic acid (SA)-mediated resistance to pathogens, including the biotrophic powdery mildew pathogens Golovinomyces cichoracearum and Blumeria graminis, and the downy mildew pathogen Hyaloperonospora parasitica, probably by limiting the initiation of cell death and the establishment of the hypersensitive response (HR).
Statistics
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PSSM-Id: 462076
Aligned: 84 rows
Threshold Bit Score: 155.837
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002288436  757 WV-PMQSSGLEVR-SHGYLASKTKISaPA-DLYECIGTDCFASNARIPDIAPRV--------------VLPdv------- 812 
EGD77718       30 HT-------YKLRvGPNYSKRKQKEAcTD-ALYDLVACDLFSSAKKITNICKHVqlptlpp------------------- 82  
XP_001747287  146 ydlakgstVFQTRiGPDYKRHKKKAPsGP-PMYEQIGNDIFVSDKRAMNICRRV--------------RLP--------- 201 
XP_002501399  142 WSaNPLGQGFRLR-GKQYKKDRKKFPsEK-PLYDVVHVLAFRSDKQKLDFGELIfg-----------gDV---------- 198 
CBJ27524      337 WS-NGIDSVFHVR-GKGYMQDKLKVs-PAeSLYDMVGLDIFSTEARVGNMASEVvldt-------atkDLP--------- 397 
XP_002293070  343 WT-PVDGTEFKVRtGPNYPRLGKKENsKP-SLYEVYSVRFFRSGKRTVGGATRIm-------------PLPemvegvvdg 407 
EDQ88795       58 WD-VGDGSTFRVRrGPDYKKNGKKELsLP-QMYDAVAVDCFRVERRCYPIAPIInlpalpdhladwkhED---------- 125 
XP_002904083  650 WT-TTSAEMFTVR-SSDYKKSRKKEp-SKaALFEFIGADLVCTESKVDLISQRV--------------EFP--------- 703 
RAW39965      357 WT-QIDATRFNVRqGPNYRKTKLKAa-SAtALLELVAVDVYQSDLKADNVGSIV--------------DLS--------- 411  Phytophthora ...
KAE8889953    356 WA-QVDATRFNVRqGPNYRKTKMKAa-SApALLELVAVDVYQSVVKADNVGSIV--------------DLS--------- 410  Phytophthora ...
XP_002288436  813 -------------------qFSDGD-SPkt-wkSPDIMVISVSIPteapsf------gkstddGQGTTMVGYFkmk---- 861 
EGD77718       83 --------------------------gmgkvndVPPFFVVNLLLPmyrppvl-----rrgpedGETVHLVLYFllkpasq 131 
XP_001747287  202 ---------------------APPSpRDhpsggVPPYLVVTVMFPdyaapl-------fgakeGKTFNLACYFlmkeetw 253 
XP_002501399  199 --------------------------GEii-hgCPTVYIANLMLPdyppanplwgkkekggpdGPGQHIVVVArmteetr 251 
CBJ27524      398 --------------------AVSVP-G------VPPLLVINVQLPsaspal------mtsaedGPGVQCVMYFrmkest- 443 
XP_002293070  408 vnsdaegtekgtkeskllsgGNSSHlELkg-tkIPDVLVVHFMLPyeppnm------fkqkddGQGGECVYYLrpsqrfl 480 
EDQ88795      126 ---------------------------------VPATFILNIQLPgaaakm------fssdidGPTVHLIIYYhlrpdaa 166 
XP_002904083  704 --------------------PEHEN-SR--------LFIINAQLPsygpsvw-----gdgsydGPGYSLALYWkip---- 745 
RAW39965      412 --------------------ALKPE-TG-----NLDLFIVNCQVPsyqpsnpl---wgekqgdGPGFNFITYFaip---- 458  Phytophthora ...
KAE8889953    411 --------------------VLKPI-TG-----DLDLFIVNCQVPsyqpsnpl---wgekqgdGPGFNFVTYFaip---- 457  Phytophthora ...
XP_002288436  862 ----eeTRAilRRITAAdydastdtaddeldvqkrITN----Gvrlw----------eryCKQAPndpEFQARFKLVPHA 923 
EGD77718      132 imlhedN-----------------------------IDleapGvrllrn--------------filndDMKDRFKMIAGL 168 
XP_001747287  254 hhlqpeA-----------------------------IEsappAyrll----------rdfVQRd----DLKDRFKVIANL 290 
XP_002501399  252 aelercGGD---------------------------VDkmapEvglmarhfragphdengMDMPPhpaPVRHCTKMVCMV 304 
CBJ27524      444 --------aramenLAT------------------ASE----Gvrlw----------vtyCQRVGvddDFQGRFKCIAVI 483 
XP_002293070  481 devagrTPSt-------------------------------aAtqlf----------irwCNECHsnpDMRARFKCMALV 519 
EDQ88795      167 raigegVERq-------------------------------pAhdlw----------arwCREAFddeKMRGRFKMIGVV 205 
XP_002904083  746 ----deIVEelKNPTTT------------------TLK----Lfkr-----------fleAGDDT---SLTDRFKVIAQV 785 
RAW39965      459 ----paIREmlDAPGEP------------------SLQ----Avrll----------kdfMKPQS---WVSERFKAMGIV 499  Phytophthora ...
KAE8889953    458 ----paIREmlDAPGDP------------------PLQ----Avrll----------knfMQPQS---WVSERFKAIGIV 498  Phytophthora ...
XP_002288436  924 -NLVELGCPA--Yia-----kyNGKP-VLIK-----RNQvtgfftdypalNAMEFDISLHPFPYlFKQATSYLKeNYFDK 989 
EGD77718      169 mNPGESLSMTt-Aslv---rsyNFKP-LLTR-----PQHewst----dgeTYIECAIDVHRFNFlTRTTWHSVR-GSTSK 233 
XP_001747287  291 vNVESSPFNKl-Vksli--ssyNMKP-VLTR-----PQHhwft----dhrTYLEVNVDVHIFAYpARSTWDSLR-PVLNQ 356 
XP_002501399  305 aD----GQQElpMvvrvaigqgNGKP-FMVN-----KTGyftk---hegkGYFEIAVNAHNFGQfATNGLRNCH-SFFKH 370 
CBJ27524      484 aNSESLGLPS--Fit-----kyNGKP-VLIN-----RSGhwv-----kgeNYIENTINVHRFSFiAKKSLHSLK-GLFKD 544 
XP_002293070  520 rDIEKHNFG---Llk-----syNGKP-VLIT-----ESGrvcsg-yhgdtRYLEMTANVHYWAFmAKKGFVSLI-PKFKN 583 
EDQ88795      206 dNFKDIGLPSi-Let------yNGKPcIIYKtgsiaKGAd---------cTYIEAGINVHLFPYlTRNMIWSYR-AKSLD 268 
XP_002904083  786 tNQDECGITGmaKkll---vshNATP-VLTR-----PQHriyh----fknGTTEIVVDVHAFSYiARRGIHSLI-DKTAR 851 
RAW39965      500 vNPQEQTLGRaeRrll---etyNGQP-ILTR-----PQHhfy-----rgdGYFEVDVNAHDFNYiARKGLVGVS-THACN 564  Phytophthora ...
KAE8889953    499 vNPEEQKLGRaeRhll---etyNGQP-ILTR-----PQHqfy-----rgnGYFEVDVNAHDFNYvARKGLVGVT-DHACN 563  Phytophthora ...
XP_002288436  990 AVVTFGFVVEGRCDDELPEVMIGAMRVCY 1018
EGD77718      234 LNIEAAFTIEGRGDDELPEWLLGHnifhh 262 
XP_001747287  357 LTIESGLVVEARDNEEMPEQLLGialshe 385 
XP_002501399  371 LVLDIGVTLQGDHPDELPERLLFAFRAvk 399 
CBJ27524      545 MVLHLGFTVEGRAADELPESLLACSTLhy 573 
XP_002293070  584 MQMEVGFTIEAHAEHEMPECMLGSTVLSY 612 
EDQ88795      269 MQLHIAGTIEARSDEEMPERVVFTNRITN 297 
XP_002904083  852 LVIDVAFVIQGETDEELPEQVLGCCRLDR 880 
RAW39965      565 MILDFGFVLEGQEDNELPEQILGCVRLCK 593  Phytophthora cactorum
KAE8889953    564 MILDFGFVLEGQEDHELPEQILGSVRLCK 592  Phytophthora fragariae
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