Conserved Protein Domain Family
DUF493

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pfam04359: DUF493 
Protein of unknown function (DUF493)
This domain is likely to act in a regulatory capacity like pfam01842 domains. This domain has a remarkable property in that the C-terminal residue of every protein in the family lies up in the alignment. This suggests that the C-terminal residue plays some important functional role (Bateman A pers obs).
Statistics
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PSSM-Id: 461274
Aligned: 162 rows
Threshold Bit Score: 48.6582
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q2Y7I7        10 STLIEYPCDFPIKIMGRvgspsgippsaatleyRRQDFSQNVLAIVKRHAP-DFDEAT-MEVRISRKSNYLSLTC-TIRA 86  Nitrosospira mu...
XP_002961860  52 skvNTYPMERGFTAIGT----------------GGDDFVRAMVLAVETVLQ-ISVSTEeISSKLSSQGKYISVKIgPVAV 114
XP_002990810  45 ervnLYPMVRRFTAIGR----------------GGDDFAQAMVVAVETVLQ-SPIPRAwVSKRLSSRGKYISVRIgPVVV 107
CBN78749      35 DALVEYPGSFDLKIIGV----------------DDDTFVSDIRKAVAGCLTnGEDNVIkCSTR--EKGKYTSITL-KVRV 95 
CBJ26213      96 eYLVDYPCEFEIKVIGI----------------NEGSFADDIAATVSAVCEvETSDVRfTV-RDTTSGRYQSITV-HAPV 157
XP_002186513 163 EALVDYPCDFTMKIVGA----------------NEGAFVEEMVAVVAESCLvQADSIQhSVR---ALGKWTSVTV-QAPV 222
WP_013257916  24 ERHHSFPGPYMFKVIGF----------------EAPSYVDDVRRAVEGVLG-PLGEEGqMRCRPSSGGKYVAVTL-EVLV 85  Desulfarculus b...
WP_013629171  12 DATHQFPCTYTFKVIGE----------------SNEKFVQNIVVAVRAGLGlEFDPPYrS--RETRGGRHIALTF-EPVA 72  Rubinisphaera b...
WP_013566264  10 ESQHAFPGSYCIKAIGS----------------AADDFVERVLEAARTELAvPSDLDYsE--RWTNDRRHVSVTL-DLAV 70  Isosphaera pallida
WP_015248890  11 eSTHFFPGVYRIKAIGL----------------TDENFEARVLEAVVLQLAsASELDYtS--RTTPGGRHVAVTM-DVTV 71  Singulisphaera ...
Q2Y7I7        87 VSREQLDALYQELCDHPTVVMV 108 Nitrosospira multiformis ATCC 25196
XP_002961860 115 QSSEQVRAVYNAMRCDSRMKYF 136
XP_002990810 108 NSGDQVRAVYNAMRRDVRMKYF 129
CBN78749      96 ENSTQLYKCYEVINEDKRVKFK 117
CBJ26213     158 KNATMLYKCYELIDEDPRVKFK 179
XP_002186513 223 QSAEMLYGLYEVIDRDPRVKFK 244
WP_013257916  86 RDSGQVLAVYAALRGVSGVVal 107 Desulfarculus baarsii
WP_013629171  73 ETAEQVLAVYQNIQQTDGVILL 94  Rubinisphaera brasiliensis
WP_013566264  71 QSSDQVLRIYARLREVAGIKLV 92  Isosphaera pallida
WP_015248890  72 QNAQQVREIYASLGELKGLtll 93  Singulisphaera acidiphila
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