1IYM


Conserved Protein Domain Family
RING-H2_EL5-like

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cd16461: RING-H2_EL5-like 
Click on image for an interactive view with Cn3D
RING finger, H2 subclass, found in rice E3 ubiquitin-protein ligase EL5 and similar proteins
EL5, also known as protein ELICITOR 5, is an E3 ubiquitin-protein ligase containing an N-terminal transmembrane domain and a C3H2C3-type RING-H2 finger that is a binding site for ubiquitin-conjugating enzyme (E2). It can be rapidly induced by N-acetylchitooligosaccharide elicitor. EL5 catalyzes polyubiquitination via the Lys48 residue of ubiquitin, and thus plays a crucial role as a membrane-anchored E3 in the maintenance of cell viability after the initiation of root primordial formation in rice. It also acts as an anti-cell death enzyme that might be responsible for mediating the degradation of cytotoxic proteins produced in root cells after the actions of phytohormones. Moreover, EL5 interacts with UBC5b, a rice ubiquitin carrier protein, through its RING-H2 finger. EL5 is an unstable protein, and its degradation is regulated by the C3H2C3-type RING-H2 finger in a proteasome-independent manner.
Statistics
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PSSM-Id: 438124
Aligned: 26 rows
Threshold Bit Score: 72.2929
Created: 2-May-2013
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteputative active
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Structure:1IYM; Oryza sativa El5 binds two Zn2+ ions through its RING-H2 finger.
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1      #  #               # #  #  #           #  # 
1IYM_A      7 ECAVCLAELEDGEeaRFLPRCGHGFHAECVDMWLg-sHSTCPLCR 50  rice
Q9FGJ6    106 ECAICLSEFEQGEsiQVLEKCQHGFHVKCIHKWLs-tRSSCPTCR 149 thale cress
ELR20311  340 SCVICLSDFTTGDt-LRRMECMHVFHKECVDKWLq-qSKKCPSCN 382 Acanthamoeba castellanii str. Neff
AFG55073   54 DCAICLSDFVDGEklRILPGCSHSFHMDCIDRWLn-fNSSCPSCR 97  loblolly pine
O22755    101 ECAICLTDFADGEeiRVLPLCGHSFHVECIDKWLv-sRSSCPSCR 144 thale cress
Q9FL42     93 PCSICLCDYEAREpvRCIPECNHCFHTDCVDEWLr-tSATCPLCR 136 thale cress
RSH85673  753 RCLICLSEYETGEe-CRVLNCRHAFHKDCVDQWLskgSNSCPACR 796 Saitozyma podzolica
P0CH03    319 VCPICLSEYASKEtvRFIPECDHCFHVECIDVWLk-iHGSCPLCR 362 thale cress
Q9C7E9    252 ICPICLSEYASKEtvRCMPECDHCFHVQCIDEWLk-iHSSCPVCR 295 thale cress
ORX80031  542 DCPICLLNYENNEt-LRKLLCSHTFHKDCIDNWFk-tSSTCPVCR 584 Anaeromyces robustus

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